Novel Nasal Epinephrine Shows Comparable Absorption to EpiPen(R) in a Feasibility Study Needle-Free Epinephrine for Proposed Treatment of Allergy-Induced Anaphylaxis SAN FRANCISCO, Sept. 10, 2013 (GLOBE NEWSWIRE) -- Shin Nippon Biomedical Laboratories, Ltd. ('SNBL' Chairman and CEO, Ryoichi Nagata MD PhD FFPM, Tokyo, Japan) and G2B Pharma Inc. ('G2B' Chairman and CEO, Nigel Ten Fleming PhD, San Francisco, USA) announce the completion of a preclinical feasibility study investigating a nasally-delivered epinephrine (adrenaline) formulation for treating anaphylaxis. The study demonstrated that this needle-free nasal epinephrine formulation succeeded in achieving rapid absorption in peripheral blood comparable to EpiPen^®, the leading injectable product. G2B and SNBL have agreed to use SNBL's µco™ System nasal delivery platform with the Fit-lizer® nasal device, together with G2B's proprietary drug strategy, to develop a nasally-delivered epinephrine product. The proposed product, which is covered by multiple issued or pending patents worldwide, is expected to enter clinical trials in 2014. "We are very excited to report the results of this study and to announce our relationship with SNBL," said Nigel Ten Fleming PhD. "SNBL brings a unique combination of assets. Not only is SNBLa world class CRO, it also possessesa superior nasal technology platform and expertise inthedevelopment of nasally deliveredpharmaceuticals. Only a small fraction of diagnosed at-risk anaphylaxis patients carry an auto-injector, which is in part due to needle phobia and lack of training in their use. Our joint product promises to provide patients [and their families] with a needle-free alternative." "SNBL is pleased to support the efforts of the team at G2B," stated Ryoichi Nagata MD PhD FFPM."Anaphylaxis commanded recent headlines in Japan when a child tragically died of the condition. We believe that a simple and effective emergency treatment, without needles, will be a benefit to patients and caregivers alike." Anaphylaxis is a systemicandlife-threatening allergic reactionto food allergies, insect stings, and other triggers. It is characterized byanaphylactic shockassociated with a decrease in blood pressure anddeterioration in consciousness.The prevalence of food allergiesisestimatedat 3-4% in the US and1-2 % in Japan, with recent studiesdocumentinga rapid increase in the prevalence of food allergies among childreninboththe U.S. and Europe. Epinephrine is considered the gold standard treatment for anaphylaxis. EpiPen^® is a registered trademark of MylanInc. Fit-lizer^TM and µco^TM are trademarks of SNBL, Ltd. SNBL For more than 55 years, SNBL (Shin Nippon Biomedical Laboratories, Ltd) has been a leader in helping biopharmaceutical companiestogenerate high quality data with the exceptional precision needed to rapidly advance new medical therapies and innovations that improve patients' lives.SNBL has facilities in Japan, the United States, China, and Cambodia.SNBL'spatented nasal delivery technology platformhas been shown tosignificantly enhance the absorption of powder nasal drugs from the nasal mucosa. The technology has been shown in several clinical trials to be safe and effective. (Web site: http://www.snbl-nds.co.jp/en/). G2B Pharma G2B Pharma Inc.is a specialty pharmaceutical company, focused on the reformulation of off-patent drugs. G2B's mission is to take drugs that have recently come off patent and reformulate them into a different dosage form that may achieve clinically significant benefits "making good drugs better". (Web site: http://www.g2bpharma.com). CONTACT: Shin Nippon Biomedical Laboratories, Ltd. Tokyo Stock Exchange, First Section: Code # 2395 NDS Division, Mic Iwashima (firstname.lastname@example.org) G2B Pharma Inc. Executive Chairman, Michael Doodson (Tel: (415) 320-4391) or Chairman and CEO, Nigel Ten Fleming PhD (NFleming@G2BPharma.com) G2B Pharma Inc. logo
Novel Nasal Epinephrine Shows Comparable Absorption to EpiPen(R) in a Feasibility Study
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