Children's Mercy Receives $5.86 Million NIH Grant For 50-Hour Genomic Diagnosis In Critically Ill Newborns

    Children's Mercy Receives $5.86 Million NIH Grant For 50-Hour Genomic
                     Diagnosis In Critically Ill Newborns

PR Newswire

KANSAS CITY, Mo., Sept. 4, 2013

KANSAS CITY, Mo., Sept. 4, 2013 /PRNewswire/ --Children's Mercy Hospital in
Kansas City, Mo. has received a research grant for $5.86 million from the
Eunice Kennedy Shriver National Institute of Child Health and Human
Development and the National Human Genome Research Institute at the National
Institutes of Health. The grant allows Children's Mercy to assess the benefits
of making STAT-Seq, currently the fastest whole genome analysis in the world,
routine for diagnosis of acutely ill infants in neonatal intensive care units

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"We are very grateful to receive this pioneering federal award," said Dr.
Stephen Kingsmore, Director of the Center for Pediatric Genomic Medicine at
Children's Mercy and Principal Investigator of the grant. "We believe that 30
percent of the babies in our NICUs are likely to benefit from next-day genome
sequencing. This grant will generate the critical data to guide the use of
rapid genome sequencing in the diagnosis and treatment of acutely ill babies."

The award, "Clinical and Social Implications of 2-day Genome Results in
Acutely Ill Newborns," will fund studies to improve the speed and
cost-effectiveness of STAT-Seq, and to evaluate the benefits, and potential
harms, of rapid genome sequencing in newborns in nurseries and intensive care

"More than 20 percent of infant deaths are caused by congenital malformations,
deformations and chromosomal abnormalities caused by genetic illnesses," said
Dr. Howard Kilbride, Director of the Division of Neonatology for Children's
Mercy. "Families want answers, and they want them quickly. This technology –
and this grant, in particular – will help make that happen." 

STAT-Seq is being developed by the hospital's Center for Pediatric Genomic
Medicine in collaboration with Illumina Inc., and uses rapid whole genome
sequencing to help physicians make a timely diagnosis in newborns who are
acutely ill, likely with a genetic disease. STAT-Seq sets a new standard for
speed, taking less than 50 hours from test order to the delivery of an interim
report to a physician.

Children Mercy's research under this grant will in part be made possible by
industry-leading newborn screening technologies from PerkinElmer, whose
solutions have helped screen more than 400 million babies worldwide for a
variety of life-threatening diseases.

Visit for more information on the Center for
Pediatric Genomic Medicine.

About Children's Mercy Hospital

Children's Mercy Hospital, located in Kansas City, Mo., is one of the nation's
top pediatric medical centers. The 354-bed hospital provides care for children
from birth through the age of 21, and has been ranked by U.S. News & World
Report as one of "America's Best Children's Hospitals" and recognized by the
American Nurses Credentialing Center with Magnet designation for excellence in
nursing services. Its faculty of 600 pediatricians and researchers across more
than 40 subspecialties are actively involved in clinical care, pediatric
research, and educating the next generation of pediatric subspecialists. For
more information about Children's Mercy and its research, visit or download our mobile phone app CMH4YOU for all phone
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About The Center for Pediatric Genomic Medicine at Children's Mercy Hospital

The first of its kind in a pediatric setting, The Center for Pediatric Genomic
Medicine combines genome, computational and analytical capabilities to bring
new diagnostic and treatment options to children with genetic diseases. As a
leading researcher in pediatric genomic medicine, Stephen Kingsmore, M.B.
Ch.B., D.Sc., FRCPath, was named to Medscape's Best Physicians list and his
team's STAT-Seq test was one of TIME magazine's Top 10 Medical Breakthroughs
of 2012. For more information about STAT-Seq, TaGSCAN, diagnostic tests and
current research, visit

SOURCE Children's Mercy

Contact: Melissa Novak, Phone: (816) 346-1341, E-mail:; or
Carin Ganz, Phone: (212) 373-6002, E-mail:
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