DGAP-News: WILEX AG: WILEX subsidiary Heidelberg Pharma signs license agreement for the development of Antibody Targeted

 DGAP-News: WILEX AG: WILEX subsidiary Heidelberg Pharma signs license agreement  for the development of Antibody Targeted Amanitin Conjugates (ATACs) with Roche  DGAP-News: WILEX AG / Key word(s): Alliance WILEX AG: WILEX subsidiary Heidelberg Pharma signs license agreement for the development of Antibody Targeted Amanitin Conjugates (ATACs) with Roche  02.09.2013 / 07:02  ---------------------------------------------------------------------  PRESS RELEASE   WILEX subsidiary Heidelberg Pharma signs license agreement for the development of Antibody Targeted Amanitin Conjugates (ATACs) with Roche  Munich, Germany, 02 September 2013 - WILEX AG (ISIN DE0006614720 / WL6 / FSE) today announced that its subsidiary Heidelberg Pharma GmbH, Ladenburg, Germany, signed a license agreement with Roche (SIX: RO, ROG; OTCQX: RHHBY) covering the development of a novel class of antibody drug conjugates (ADCs) based on Heidelberg Pharma's patented technology to couple α-Amanitin to antibodies. The license agreement covers initial joint research to apply this technology to multiple Roche antibodies towards the identification of development candidates with favourable efficacy/safety profiles.  Heidelberg Pharma will receive regular payments for granting access to its technology and providing research services. Roche will subsequently have the opportunity to exercise options for licenses to develop and market selected Antibody Targeted Amanitin Conjugates (ATACs). Heidelberg Pharma will manufacture these substances and receive customary upfront payments, milestone payments and royalties for each development candidate selected by Roche.  α-Amanitin is a bicyclic peptide naturally occurring in the green Death Cap mushroom. It potently inhibits the biosynthesis of RNA, a mechanism which is critical for the survival of cells. Accordingly, ATACs exhibit comparable activity against proliferating and resting tumour cells. This proliferation independent activity differentiates ATACs from other ADCs, which preferentially target proliferating tumour cells. As an additional advantage ATACs could offer a substantial capability to overcome the resistance mechanisms which might limit the efficacy of other antibody drug conjugates. The ATACs tested so far have shown strong anti-tumour activity in several preclinical tumour models.  Dr Jan Schmidt-Brand, Managing Director of Heidelberg Pharma GmbH and Chief Financial Officer of WILEX AG, commented: 'We are delighted about the opportunity to collaborate with a company as renowned as Roche. This cooperation is an important external validation of our technology. We will use this cooperation to jointly explore and technically expand the applicability of our technology to selected antibodies.'  Dr Klaus Bosslet, heading Roche Discovery Oncology in Penzberg, Germany, added: 'We look forward to collaborating with Heidelberg Pharma to elect and develop the most promising ATACs. Ultimately, these ATACs may provide novel treatment options for cancer patients, whose tumours do not respond to available cancer therapeutics.'   About Heidelberg Pharma Heidelberg Pharma GmbH is a wholly owned subsidiary of WILEX AG and is located in Ladenburg, Germany. The Company offers services for the pre-clinical drug discovery and development including explorative pharmacology, drug metabolism and pharmacokinetics (DMPK) analysis and molecular biology in oncology or inflammatory/autoimmune diseases. The services are dedicated to a high grade of flexibility, efficient realisation and high quality. Heidelberg Pharma's R&D flagship is its proprietary 2nd generation ADC technology platform (ATAC) for more effective anti-cancer drugs.  About WILEX WILEX AG is a biopharmaceutical company based in Munich, Germany. Focused on oncology, the Company develops diagnostic and therapeutic product candidates for the specific detection and targeted treatment of various types of cancer. In the field of therapeutics, WILEX develops antibodies and small molecules. (RENCAREX(R): Phase III, MESUPRON(R): Phase II, WX-554: Phase Ib/II and WX-037: Phase I). In the field of diagnostics, REDECTANE(R) is an antibody-based imaging agent that is currently in a Phase III programme. The Company also has a portfolio of biomarker assays that are marketed via its US subsidiary WILEX Inc. under the brand Oncogene Science. WILEX's subsidiary Heidelberg Pharma GmbH offers preclinical contract research services and a highly promising antibody drug conjugate (ADC) technology platform. The business model of WILEX comprises research and product development as well as the commercialisation of its activities. WILEX's customers and partners include leading international pharmaceutical companies. Website: http://www.WILEX.com, ISIN DE0006614720 / WKN 661472 / Symbol WL6.  Contact   Corporate Communications & IR              Business Development WILEX AG                                   Heidelberg Pharma GmbH Katja Arnold (CIRO) & Sylvia Wimmer        Dr. Marcel Linssen Grillparzerstr. 10                         CBO, Executive Vice President 81675 Munich, Germany                      Schriesheimer Str. 101 Tel.: +49 (0)89-41 31 38-126 / 29          68526 Ladenburg, Germany Mobil: +49 (0)160 93 60 30 22              Tel.: +49-(0) 6203 1009-40 Email: investors[at]wilex.com              Email: m.linssen[at]hdpharma.com   This communication contains certain forward-looking statements relating to the Company's business, which can be identified by the use of forward-looking terminology such as 'estimates', 'believes', 'expects', 'may', 'will', 'should', 'future', 'potential' or similar expressions or by a general discussion of the Company's strategy, plans or intentions. Such forward-looking statements involve known and unknown risks, uncertainties and other factors, which may cause our actual results of operations, financial position, earnings, achievements, or industry results, to be materially different from any future results, earnings or achievements expressed or implied by such forward-looking statements. Given these uncertainties, prospective investors and partners are cautioned not to place undue reliance on such forward-looking statements. We disclaim any obligation to update any such forward- looking statements to reflect future events or developments.   End of Corporate News  ---------------------------------------------------------------------  02.09.2013 Dissemination of a Corporate News, transmitted by DGAP - a company of EQS Group AG. The issuer is solely responsible for the content of this announcement.  DGAP's Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases. Media archive at www.dgap-medientreff.de and www.dgap.de  ---------------------------------------------------------------------   Language:    English                                                 Company:     WILEX AG                                                             Grillparzerstr. 10                                                   81675 München                                                        Germany                                                 Phone:       +49 (0)89 41 31 38 - 0                                  Fax:         +49 (0)89 41 31 38 - 99                                 E-mail:      info@wilex.com                                          Internet:    www.wilex.com                                           ISIN:        DE0006614720                                            WKN:         661472                                                  Listed:      Regulierter Markt in Frankfurt (Prime Standard);                     Freiverkehr in Berlin, Düsseldorf, München, Stuttgart       End of News    DGAP News-Service   ---------------------------------------------------------------------   228530 02.09.2013                                                        
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