SHIRE PLC: Transaction in Own Shares

Transaction in Own Shares 
August 23, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company") announces
that, in accordance with the authority granted by shareholders at the Company's
Annual General Meeting on April 30, 2013, it purchased 9,980 of its ordinary
shares of 5 pence each ("Ordinary Shares") on August 22, 2013 through both
direct purchases of Ordinary Shares, and through the purchase of Ordinary
Shares underlying ADRs. The highest and lowest price paid for the directly
acquired Ordinary Shares was 2439.00 pence per share and 2410.00 pence per
share respectively, and for those Ordinary Shares acquired though the purchase
of ADRs was 3813.00 cents per share and 3795.67 cents per share respectively. 
The purchased shares will be held as treasury shares. Following the above
purchase, the Company holds 9,655,585 Ordinary Shares as treasury shares and
has 553,225,268 Ordinary Shares in issue (excluding treasury shares). 
The purchases were made by an independent third party which makes its trading
decisions independently of, and uninfluenced by, the Company. The independence
of the third party enables the Company to continue to purchase Ordinary Shares
(including Ordinary Shares underlying ADRs) during close periods and other
prohibited periods, should they arise. The third party has been appointed by
the Company to make purchases to December 31, 2013. 
For further information please contact: 
Investor Relations                                                              
                                                                           
Eric Rojas                              erojas@shire.com     +1 781 482 0999    
                                                                           
Sarah Elton-Farr                        seltonfarr@shire.com +44 1256 894157    
NOTES TO EDITORS 
Shire enables people with life-altering conditions to lead better lives. 
Our strategy is to focus on developing and marketing innovative specialty
medicines to meet significant unmet patient needs. 
We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal,
Internal Medicine and Regenerative Medicine and we are developing treatments
for symptomatic conditions treated by specialist physicians in other targeted
therapeutic areas. 
www.shire.com 
Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX 
                                 
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-0- Aug/23/2013 06:00 GMT