Sangamo BioSciences Announces Notice Of Allowance For New Patent Application Covering Genome Modification Technology

 Sangamo BioSciences Announces Notice Of Allowance For New Patent Application
                   Covering Genome Modification Technology

Claims Cover Critical Components of TALE Technology Reinforcing the Technical
and Intellectual Property Dominance of Company in the Field of Genome

PR Newswire

RICHMOND, Calif., Aug. 14, 2013

RICHMOND, Calif., Aug. 14, 2013 /PRNewswire/ --Sangamo BioSciences, Inc.
(Nasdaq: SGMO) announced that the United States Patent and Trademark Office
(USPTO) has issued a Notice of Allowance for the U.S. patent application (US
20110301073) entitled "Novel DNA-binding Proteins and Uses Thereof." The
claims cover core architectural aspects of engineered Transcription
Activator-Like Effectors, or TALEs, which enable these proteins to be useful
in potential therapeutic applications of genome editing or gene regulation and
for the efficient use of the technology in biomedical research and plant


"The novel architectures detailed in the issuing claims are intrinsic to the
efficiency and general utility of the TALE platform and we expect them to be
broadly adopted and become the industry standard," stated Philip Gregory D.
Phil., Sangamo's vice president of research and chief scientific officer.
"When used with Sangamo's proprietary engineered FokI nucleases, or DNA
cutting domains, this technology can be harnessed to efficiently and precisely
edit gene sequences. The ability to modify the genome of plants and animals
has already transformed cell biology and holds promise for the development of
new medicines and agricultural products."

Sangamo's research in this field, initially published in a paper entitled "A
TALE Nuclease Architecture for Efficient Genome Editing" (Miller et al. Nature
Biotechnology 2011 Feb; 29 (2):143-8), led to the filing of this patent

"Sangamo is a pioneer in the field of genome modification and is developing
our proprietary zinc finger DNA-binding (ZFP) technology for therapeutic
applications in HIV/AIDS and the treatment of monogenic diseases," said Edward
Lanphier, Sangamo's president and CEO. "We are very pleased that the U.S.
Patent Office has acknowledged these new claims which expand and reinforce our
dominance of this field from both a scientific and intellectual property

About Sangamo
Sangamo BioSciences, Inc. is focused on research and development of novel
DNA-binding proteins for therapeutic gene regulation and genome editing. The
Company has ongoing Phase 2 and Phase 1/2 clinical trials to evaluate the
safety and efficacy of a novel ZFP Therapeutic^® for the treatment of
HIV/AIDS. Sangamo's other therapeutic programs are focused on monogenic
diseases, including hemophilia, Huntington's disease and hemoglobinopathies
such as beta-thalassemia and sickle cell anemia. Sangamo's core competencies
enable the engineering of a class of DNA-binding proteins known as zinc finger
DNA-binding proteins (ZFPs). Engineering of ZFPs that recognize a specific
DNA sequence enables the creation of sequence-specific ZFP Nucleases (ZFNs)
for gene modification and ZFP transcription factors (ZFP TFs) that can control
gene expression and, consequently, cell function. Sangamo has entered into a
strategic collaboration with Shire AG to develop therapeutics for hemophilia,
Huntington's disease and other monogenic diseases and has established
strategic partnerships with companies in non-therapeutic applications of its
technology including Dow AgroSciences and Sigma-Aldrich Corporation. For more
information about Sangamo, visit the company's website at

ZFP Therapeutic® is a registered trademark of Sangamo BioSciences, Inc.

This press release may contain forward-looking statements based on Sangamo's
current expectations. These forward-looking statements include, without
limitation, references to the research and development of novel ZFP TFs, ZFNs
and TALEs and their applications in research and the treatment of disease.
Actual results may differ materially from these forward-looking statements due
to a number of factors, including uncertainties relating to the initiation and
completion of our clinical trials, whether the clinical trials will validate
and support the tolerability and efficacy of ZFNs, technological challenges,
Sangamo's ability to develop commercially viable products, risks associated
with the protection of our proprietary technology and technological
developments by our competitors. For a more detailed discussion of these and
other risks, please see Sangamo's SEC filings, including the risk factors
described in its Annual Report on Form 10-K and its most recent Quarterly
Report on Form 10-Q. Sangamo BioSciences, Inc. assumes no obligation to update
the forward-looking information contained in this press release.

SOURCE Sangamo BioSciences, Inc.

Contact: Sangamo BioSciences, Inc., Elizabeth Wolffe, Ph.D., 510-970-6000,
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