Shire Launches Educational Resource for People Living with Diabetes and Their Caregivers

Shire Launches Educational Resource for People Living with Diabetes and Their
                                  Caregivers is designed to increase patient awareness of diabetic foot
ulcers and encourage immediate treatment of diabetes-related complications

PR Newswire

SAN DIEGO, Aug. 7, 2013

SAN DIEGO, Aug. 7, 2013 /PRNewswire/ --Shire plc (LSE: SHP, NASDAQ: SHPG) has
recently launched a new educational resource for people with diabetes and
their caregivers as part of its HealTogether national awareness program. is an online community designed to increase awareness and
education of diabetic foot ulcers (DFUs) and help patients better understand
that DFUs should be treated immediately.

To view the multimedia assets associated with this release, please click:


With numerous pages of educational content related to diabetes and
diabetes-related complications, including an animation that simplifies the
complexity of DFUs, downloadable support material that helps patients speak
about their DFU with their healthcare provider, and a tool to assist in the
location of specialists for treatment, is a convenient
resource for anyone impacted by diabetic foot ulcers. The website also
includes a questionnaire to help determine who is at risk for a DFU and videos
of patients who are being treated for their DFUs.

"Diabetic foot sores, or ulcers, are arguably one of the most common
complications of diabetes with 25% of people with diabetes experiencing a DFU
in their lifetime," saidDr. Lee C. Rogers, D.P.M. co-medical director of the
Amputation Prevention Center at Valley Presbyterian Hospital in Van Nuys,
Calif. "Because an untreated DFU canbecome chronic andlead toaserious
complication, such as amputation, we want to provide as much education as
possible to avoid this outcome and help patients understand that they're not
alone- there is help and support available." is the foundation of Shire's nationwide HealTogether program
which is dedicated to promoting proper foot care for people with diabetes,
educating individuals about DFUs, and encouraging those with non-healing DFUs
to talk to their doctors about seeing a wound care specialist.

About Diabetic Foot Ulcers (DFUs)

Diabetic foot ulcers are wounds that can develop on the feet of people with
diabetes. They are often difficult to heal and may become chronic in nature.

There are several reasons that wounds may not heal, but one major reason may
be that over time high blood sugar levels can injure blood vessels, which may
result in decreased blood flow to the wound.^^[i]

DFUs are a common complication in patients with diabetes. Among people with
diabetes, up to 25% experience a DFU in their lifetime^^[ii] and the annual
incidence is approximately 3.4%^^[iii]^,^[iv]


Shire enables people with life-altering conditions to lead better lives.

Our strategy is to focus on developing and marketing innovative specialty
medicines to meet significant unmet patient needs.

We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal,
Internal Medicine and Regenerative Medicine and we are developing treatments
for symptomatic conditions treated by specialist physicians in other targeted
therapeutic areas.


Statements included in this announcement that are not historical facts are
forward-looking statements. Forward-looking statements involve a number of
risks and uncertainties and are subject to change at any time. In the event
such risks or uncertainties materialize, Shire's results could be materially
adversely affected. The risks and uncertainties include, but are not limited
to, that:

  oShire's products may not be a commercial success;
  orevenues from ADDERALL XR are subject to generic erosion;
  othe failure to obtain and maintain reimbursement, or an adequate level of
    reimbursement, by third-party payors in a timely manner for Shire's
    products may impact future revenues and earnings;
  oShire relies on a single source for manufacture of certain of its products
    and a disruption to the supply chain for those products may result in
    Shire being unable to continue marketing or developing a product or may
    result in Shire being unable to do so on a commercially viable basis;
  oShire uses third party manufacturers to manufacture many of its products
    and is reliant upon third party contractors for certain goods and
    services, and any inability of these third party manufacturers to
    manufacture products, or any failure of these third party contractors to
    provide these goods and services, in each case in accordance with its
    respective contractual obligations, could adversely affect Shire's ability
    to manage its manufacturing processes or to operate its business;
  othe development, approval and manufacturing of Shire's products is subject
    to extensive oversight by various regulatory agencies and regulatory
    approvals or interventions associated with changes to manufacturing sites,
    ingredients or manufacturing processes could lead to significant delays,
    increase in operating costs, lost product sales, an interruption of
    research activities or the delay of new product launches;
  othe actions of certain customers could affect Shire 's ability to sell or
    market products profitably and fluctuations in buying or distribution
    patterns by such customers could adversely impact Shire's revenues,
    financial conditions or results of operations;
  oinvestigations or enforcement action by regulatory authorities or law
    enforcement agencies relating to Shire's activities in the highly
    regulated markets in which it operates may result in the distraction of
    senior management, significant legal costs and the payment of substantial
    compensation or fines;
  oadverse outcomes in legal matters and other disputes, including Shire's
    ability to obtain, maintain, enforce and defend patents and other
    intellectual property rights required for its business, could have a
    material adverse effect on Shire's revenues, financial condition or
    results of operations;

and other risks and uncertainties detailed from time to time in Shire's
filings with the U.S. Securities and Exchange Commission, including its most
recent Annual Report on Form 10-K.

[i] American Diabetes Association. Living with diabetes: other specialists.
Accessed October 29, 2012.

[ii] Singh N, Armstrong DG, Lipsky BA. Preventing foot ulcers in patients with
diabetes. J Amer Med Assoc. 2005;293:217-228.

[iii] Lavery LA, Armstrong DG, Wunderlich RP, Tredwell J, Boulton AJ. Diabetic
foot syndrome: evaluating the prevalence and incidence of foot pathology in
Mexican Americans and non-Hispanic whites from a diabetes disease management
cohort. Diabetes Care. 2003;26:1435-1438.

[iv] American Diabetes Association. Living with diabetes: foot care.
Accessed January 27, 2013.

SOURCE Shire plc

Contact: Katie Sweet,, +1 858 754 5761
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