Pancreatic Cancer Therapy by MHI's "vero4DRT" Radiation Therapy

Pancreatic Cancer Therapy by MHI's "vero4DRT" Radiation Therapy System 
World's First Application of Dynamic Tracking with IMRT Monitored in Real Time 
Tokyo, July 30, 2013 - (JCN Newswire) -  The "vero4DRT," a radiation
therapy system featuring tracking irradiation capability-marketed as the
"MHI-TM2000 Linear Accelerator"-that was earlier delivered to Kyoto
University Hospital, has now entered into service for dynamic tracking with
intensity-modulated radiation therapy (IMRT) for pancreatic cancer. The system
integrates two advanced treatment methods: 1) a dynamic tracking function that
tracks a respiratorily moving carcinomatous lesion in real time, and
continuously irradiates the targeted lesion with pinpoint accuracy; and 2)
IMRT, which is one of the newest irradiation techniques in radiotherapy. The
inauguration of the new vero4DRT system at Kyoto University Hospital marks a
world first in the application of dynamic tracking with IMRT through real-time
Radiation therapy for cancer today is moving forward in pursuit of sufficient
irradiation of the carcinomatous lesion and minimal radiation effect on nearby
internal organs, normal tissue and organs at risk. IMRT is an innovative
therapy method that achieves focused irradiation doses into such lesions. It
incorporates the newest irradiation technique whereby dose intensity
distribution at the irradiation target is modulated and irradiation is
performed from multiple directions, enabling the formation of a high-dose area
corresponding precisely to the complex shape of the carcinomatous lesion and
reduction in the dose irradiated to normal organs. IMRT is already contributing
to improved results in the treatment of numerous cancers such as prostate
cancer and head and neck cancers. But with lesions in internal organs such as
the lungs, liver or pancreas that move along with the patient's
respiration, treatments involving use of highly accurate irradiation techniques
such as IMRT were not easy to perform until now. 
The vero4DRT is today's most advanced radiation therapy system. By
integrating MHI's image processing technologies with its high-precision
irradiation technologies, the vero4DRT can perform highly accurate
target-tracking irradiation monitored in real time, even with lesions that move
due to respiration, etc. The integration of dynamic-tracking therapy and IMRT
has now enabled patients of pancreatic cancer, whose lesions move by
respiration, to be treated with minimal stress by breathing normally even
during treatment. Besides minimizing potential side-effects on healthy tissue,
the system thus reduces the burdens on both the patient and the attending
medical staff. 
This research was conducted with support from the "Funding Program for
World-Leading Innovative R&D on Science and Technology (FIRST
Program)", which is instituted by the Council for Science and Technology
Policy (CSTP), through the Japan Society for the Promotion of Science (JSPS).
Support in medical aspects was provided by Kyoto University and the Institute
of Biomedical Research and Innovation. 
In developing the vero4DRT system, MHI was supported by the New Energy and
Industrial Technology Development Organization (NEDO). Full-scale entry into
the medical equipment field began with acquisition of pharmaceutical approval
for the system in January 2008. Sales activities in both the domestic and
global markets got under way in 2010 after receiving authorization to
manufacture and market the vero4DRT as a system equipped with a
tracking-irradiation feature. Going forward, as the system is expected to come
into wider usage for even more advanced therapies, an increasing number of
institutions are expected to adopt it, and MHI intends to respond with even
more proactive sales expansion activities. 
About Mitsubishi Heavy Industries 
Mitsubishi Heavy Industries, Ltd. (MHI), headquartered in Tokyo, Japan, is one
of the world's leading heavy machinery manufacturers, with consolidated
sales of 2,820.9 billion for the year ended March 31, 2012. MHI's diverse
lineup of products and services encompasses shipbuilding, power plants,
chemical plants, environmental equipment, steel structures, industrial and
general machinery, aircraft, space rocketry and air-conditioning systems. For
more information, please visit the MHI website at 
Mitsubishi Heavy Industries
Hideo Ikuno
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