Estée Lauder Clinical Trial Finds Link between Sleep Deprivation and Skin Aging

  Estée Lauder Clinical Trial Finds Link between Sleep Deprivation and Skin

First-of-its-kind Study Conducted at University Hospitals Case Medical Center

Business Wire

CLEVELAND -- July 23, 2013

In a first-of-its-kind clinical trial, physician-scientists at University
Hospitals (UH) Case Medical Center found that sleep quality impacts skin
function and aging. The recently completed study, commissioned by Estée
Lauder, demonstrated that poor sleepers had increased signs of skin aging and
slower recovery from a variety of environmental stressors, such as disruption
of the skin barrier or ultraviolet (UV) radiation. Poor sleepers also had
worse assessment of their own skin and facial appearance.

The research team, led by Primary Investigator Elma Baron, MD, presented their
data this spring at the International Investigative Dermatology Meeting in
Edinburgh, Scotland in an abstract titled “Effects of Sleep Quality on Skin
Aging and Function.”

“Our study is the first to conclusively demonstrate that inadequate sleep is
correlated with reduced skin health and accelerates skin aging. Sleep deprived
women show signs of premature skin aging and a decrease in their skin’s
ability to recover after sun exposure,” said Dr. Baron, Director of the Skin
Study Center at UH Case Medical Center and Associate Professor of Dermatology
at Case Western Reserve University School of Medicine. “Insufficient sleep has
become a worldwide epidemic. While chronic sleep deprivation has been linked
to medical problems such as obesity, diabetes, cancer and immune deficiency,
its effects on skin function have previously been unknown.”

Skin functions as an important barrier from external stressors such as
environmental toxins and sun-induced DNA damage. The research team set out to
determine if skin function and appearance is also impacted by sleep quality,
which is vital to the growth and renewal of the body’s immune and
physiological systems.

The study involved 60 pre-menopausal women between the ages of 30 and 49, with
half of participants falling into the poor quality sleep category. The
classification was made on the basis of average duration of sleep and the
Pittsburgh Sleep Quality Index, a standard questionnaire-based assessment of
sleep quality. The study involved a visual skin evaluation and participation
in several non-invasive skin challenge tests including UV light exposure and
skin barrier disruption. Additionally, participants filled out a sleep log for
one week to quantify sleep duration.

The researchers found statistically significant differences between good and
poor quality sleepers. Using the SCINEXA skin aging scoring system, poor
quality sleepers showed increased signs of intrinsic skin aging including fine
lines, uneven pigmentation and slackening of skin and reduced elasticity. In
this system, a higher score means a more aged appearance. The average score in
the good quality sleepers was 2.2 versus 4.4 in poor quality sleepers. They
found no significant difference between the groups in signs of extrinsic
aging, which are attributed primarily to sun exposure, such as coarse wrinkles
and sunburn freckles.

The researchers found that good quality sleepers recovered more efficiently
from stressors to the skin. Recovery from sunburn was more sluggish in poor
quality sleepers, with erythema (redness) remaining higher over 72 hours,
indicating that inflammation is less efficiently resolved. A Transepidermal
Water Loss (TEWL) test was used at various time points to determine the
ability of the skin to serve as an effective barrier against moisture loss. In
measurements 72 hours after a skin barrier stressor (tape-stripping), the
recovery of good quality sleepers was 30% higher than poor quality sleepers
(14% vs. -6%)  demonstrating that they repair the damage more quickly.

Additionally, poor quality sleepers were significantly more likely to have a
higher Body Mass Index (BMI). For example, 23% of good quality sleepers were
obese compared to 44% of poor quality sleepers. Not surprisingly, self
perception of attractiveness was significantly better in good quality sleepers
(mean score of 21 on self evaluation) vs. poor quality sleepers (mean score of

“This research shows for the first time, that poor sleep quality can
accelerate signs of skin aging and weaken the skin’s ability to repair itself
at night,” said Dr. Daniel Yarosh, Senior Vice President, Basic Science
Research, R&D, at The Estée Lauder Companies. “These connections between sleep
and skin aging, now supported with solid scientific data, will have a profound
effect on how we study skin and its functions. We see these findings as yet
another way we can direct our scientific research toward the real needs of our
customers who want to look and feel their best.”

About University Hospitals (@UHhospitals)

University Hospitals serves the needs of patients through an integrated
network of hospitals, outpatient centers and primary care physicians. At the
core of our health system is University Hospitals Case Medical Center. The
primary affiliate of Case Western Reserve University School of Medicine,
University Hospitals Case Medical Center is home to some of the most
prestigious clinical and research centers of excellence in the nation and the
world, including cancer, pediatrics, women's health, orthopedics and spine,
radiology and radiation oncology, neurosurgery and neuroscience, cardiology
and cardiovascular surgery, organ transplantation and human genetics. Its main
campus includes the internationally celebrated UH Rainbow Babies & Children's
Hospital, ranked among the top children’s hospitals in the nation; UH
MacDonald Women's Hospital, Ohio's only hospital for women; and UH Seidman
Cancer Center, part of the NCI-designated Case Comprehensive Cancer Center at
Case Western Reserve University. University Hospitals Case Medical Center is
the 2012 recipient of the American Hospital Association – McKesson Quest for
Quality Prize for its leadership and innovation in quality improvement and
safety. For more information, go to

About Estée Lauder (@EsteeLauder)

Estée Lauder was launched in 1946 and is the flagship brand of The Estée
Lauder Companies Inc. Estée Lauder products are sold in over 150 countries and
territories. They are technologically-advanced, high-performance products with
a reputation for innovation, sophistication, and superior quality. Estée
Lauder has produced some of the most iconic skincare, makeup and fragrance
products, including Advanced Night Repair Synchronized Recovery Complex II,
Advanced Time Zone, Double Wear and Pure Color, and has two of the top 10
fragrances in the United States, Beautiful and pleasures.

Photos/Multimedia Gallery Available:



UH Case Medical Center
Jennifer Guerrieri, 216-844-2555
Estée Lauder
Tara Eisenberg, 212-572-4140
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