SHIRE PLC: Director/PDMR Shareholding

Director/PDMR Share Dealings 
June 28, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG), (the "Company") announces
that today Ordinary Shares ("Shares") and American Depository Shares ("ADSs")
of the Company, as set out below, have been acquired for the Non-Executive
Directors, being the part of their total fees that are paid in shares for the
period of service from April 1 to June 30, 2013. 
                    Type of Security (1)     Number of Shares/ADSs  
                                                                   
William Burns                  Shares                           243     
                                                                   
Dr. Steven Gillis               ADSs                             78     
                                                                   
Dr. David Ginsburg              ADSs                             73     
                                                                   
David Kappler                  Shares                           288     
                                                                   
Susan Kilsby                    ADSs                             74     
                                                                   
Anne Minto                     Shares                           253     
                                                                   
David Stout                     ADSs                             81     
(1) One ADS is equal to three Shares 
The Shares and ADSs were acquired on the London Stock Exchange and NASDAQ
respectively, at prices of £20.90 per Share and $95.20 per ADS. 
This notification relates to disclosures made in accordance with 3.1.4(R)(1)(a)
of the Disclosure and Transparency Rules. 
Tony Guthrie
Deputy Company Secretary 
For further information please contact: 
Investor Relations                                                              
                                                                           
Eric Rojas                              erojas@shire.com     +1 781 482 0999    
                                                                           
Sarah Elton-Farr                        seltonfarr@shire.com +44 1256 894157    
Notes to editors 
Shire enables people with life-altering conditions to lead better lives. 
Our strategy is to focus on developing and marketing innovative specialty
medicines to meet significant unmet patient needs. 
We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal,
Internal Medicine and Regenerative Medicine and we are developing treatments
for symptomatic conditions treated by specialist physicians in other targeted
therapeutic areas. 
www.shire.com 
                                                                         
Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX 
Press Release                                      
                                              
www.shire.com                                      
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-0- Jun/28/2013 15:30 GMT