Breakthrough Therapy Designation Status, Top-Line Results, and Business Proposals Boost Long-Term Growth in Pharmaceutical

   Breakthrough Therapy Designation Status, Top-Line Results, and Business
Proposals Boost Long-Term Growth in Pharmaceutical Companies - Research Report
               on Novartis, AstraZeneca, GSK, Sanofi, and Rigel

Editor Note: For more information about this release, please scroll to bottom.

PR Newswire

NEW YORK, June 26, 2013

NEW YORK, June 26, 2013 /PRNewswire/ --

Today, Wall Street Reports announced new research reports highlighting
Novartis AG (NYSE: NVS), AstraZeneca PLC (NYSE: AZN), GlaxoSmithKline plc
(NYSE: GSK), Sanofi (NYSE: SNY), and Rigel Pharmaceuticals, Inc. (NASDAQ:
RIGL). Today's readers may access these reports free of charge - including
full price targets, industry analysis and analyst ratings - via the links

Novartis AG Research Report

On June 21, 2013, Novartis AG (Novartis) announced that the US Food and Drug
Administration (FDA) has granted its RLX030 (serelaxin) a Breakthrough Therapy
Designation status. RLX030 (serelaxin) is an investigational treatment for
patients with acute heart failure (AHF). Novartis reported that the US FDA's
decision was supported by the efficacy and safety results from the Phase III
RELAX-AHF trial, which also showed that patients who received RLX030 had a 37%
reduction in mortality at 6 months after an acute heart failure episode
compared to those who received conventional treatment. David Epstein, Division
Head of Novartis Pharmaceuticals, stated, "RLX030 is representative of
Novartis' strong commitment to develop innovative treatments for patients in
areas of significant unmet need." Epstein added, "Commonly used medicines for
AHF only improve the immediate symptoms, so the additional effect on survival
observed with RLX030 offers hope to patients and physicians." The Full
Research Report on Novartis AG - including full detailed breakdown, analyst
ratings and price targets - is available to download free of charge at:
[ ]


AstraZeneca PLC Research Report

On June 19, 2013, AstraZeneca PLC (AstraZeneca) and Bristol-Myers Squibb
announced the top-line results of the Phase IV SAVOR-TIMI-53 (Saxagliptin
Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus)
clinical trial of Onglyza (saxagliptin). AstraZeneca reported that Onglyza met
the primary safety objective of non-inferiority and did not meet the primary
efficacy objective of superiority, for a composite endpoint of cardiovascular
death, non-fatal myocardial infarction or non-fatal ischaemic stroke, when
added to a patient's current standard of care (with or without other
anti-diabetic therapies), as compared to placebo. The Company stated that the
preliminary data of SAVOR-TIMI-53 are being analyzed, and the study results
will be submitted to the European Society of Cardiology (ESC) for potential
presentation at the ESC Congress in September 2013. The Full Research Report
on AstraZeneca PLC - including full detailed breakdown, analyst ratings and
price targets - is available to download free of charge at:
[ ]


GlaxoSmithKline plc Research Report

On June 18, 2013, GlaxoSmithKline plc (GSK) announced that it has received an
offer from Aspen Global Incorporated and Aspen Pharmacare Holdings Limited for
its thrombosis brands and Notre-Dame de Bondeville (NBD) site. GSK reported
that it has agreed on a period of exclusivity with Aspen, and the Company will
respond to the offer subject to consultation with employees and the relevant
work councils. The financial terms of the proposal were kept confidential, but
the offer includes the transfer of Arixtra and Fraxiparine brands (excluding
China, India, and Pakistan) to Aspen, along with the related manufacturing
site and the majority of employees at NDB in France and certain dedicated
commercial employees. GSK stated that the Aspen proposal is aligned with its
strategy of focusing on products with the most growth potential and on the
delivery of its pipeline. The Full Research Report on GlaxoSmithKline plc -
including full detailed breakdown, analyst ratings and price targets - is
available to download free of charge at:
[ ]


Sanofi Research Report

On June 22, 2013, Sanofi announced the first Phase III study results (EDITION
I) of its investigational new insulin U300, which showed equivalent blood
sugar control with fewer night-time low blood sugar events, compared with
Lantus (insulin glargine [rDNA origin] injection). Sanofi also announced
top-line results for its second Phase III study (EDITION II) of new insulin
U300, which showed similar blood sugar reduction while fewer patients
experienced night-time low blood sugar events, compared with Lantus. Matthew
Riddle, Professor of Medicine, Division of Endocrinology/Diabetes/Clinical
Nutrition, Oregon Health and Science University, U.S., and Principal
Investigator for the EDITION I study, commented, "To properly manage diabetes,
it is critical to control blood sugar and to reduce the risk of low blood
sugar events, especially at night." Riddle continued, "I am encouraged by
these findings, and look forward

to the results of the full Phase 3 EDITION program, which will further reveal
how this investigational

basal insulin may help people living with diabetes." The Full Research Report
on Sanofi - including full detailed breakdown, analyst ratings and price
targets - is available to download free of charge at:
[ ]


Rigel Pharmaceuticals, Inc. Research Report

On June 4, 2014, Rigel Pharmaceuticals, Inc. (Rigel) and AstraZeneca AB (AZ)
announced top-line results from OSKIRA-2 and OSKIRA-3, the remaining pivotal
Phase 3 clinical trials investigating fostamatinib, the first oral spleen
tyrosine kinase (SYK) inhibitor in development for rheumatoid arthritis (RA).
James M. Gower, Chairman and CEO of Rigel, said, "Fostamatinib continues to
demonstrate positive patient outcomes and a reasonable safety profile." Gower
continued, "We are looking forward to receiving and evaluating the full
aggregation of AZ's efforts on this program this summer as we consider the
appropriate next steps with this product candidate." The Full Research Report
on Rigel Pharmaceuticals, Inc. - including full detailed breakdown, analyst
ratings and price targets - is available to download free of charge at:
[ ]


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