FDA Approves Amgen's XGEVA® (denosumab) For The Treatment Of Giant Cell Tumor
XGEVA Becomes First FDA-Approved Treatment for This Rare Disease
THOUSAND OAKS, Calif., June 13, 2013
THOUSAND OAKS, Calif., June 13, 2013 /PRNewswire/ -- Amgen (NASDAQ:AMGN) today
announced that the U.S. Food and Drug Administration (FDA) has approved a new
indication for XGEVA^® (denosumab) for the treatment of adults and skeletally
mature adolescents with giant cell tumor of bone (GCTB) that is unresectable
or where surgical resection is likely to result in severe morbidity. XGEVA was
approved following a priority review by the FDA, a designation reserved for
drugs that offer major advances in treatment, or provide a treatment where no
adequate therapy exists.
GCTB typically affects individuals between the ages of 20 to 40. The disease
is characterized by a bone destructive tumor that often results in fractures.
When untreated, it often results in complete destruction of the affected bone,
leading to bone fracture, joint dysfunction, deformity or amputation.
The approval of XGEVA is based on positive results from two open-label trials
that enrolled patients with GCTB that was either recurrent, unresectable, or
for which planned surgery was likely to result in severe morbidity. The
overall objective response rate of the 187 patients evaluated was 25 percent.
The estimated median time to response was three months. In the 47 patients
with an objective response, 51 percent (24/47) had a duration of response
lasting at least eight months. Three patients experienced disease progression
following an objective response.
The safety profile of XGEVA in patients with GCTB was similar to that reported
in studies of patients with bone metastases, and also appeared to be similar
in skeletally mature adolescents and adults. Safety data was evaluated in 304
patients with GCTB who received at least one dose of XGEVA. Of these
patients, 145 were treated for at least one year. The most common adverse
reactions were arthralgia, headache, nausea, back pain, fatigue, and pain in
the extremity. The most common serious adverse reactions were osteonecrosis
of the jaw and osteomyelitis.
For patients with GCTB, XGEVA is administered as a subcutaneous injection (120
mg) every four weeks with additional 120 mg doses on days eight and 15 of the
first month of therapy.
"With today's XGEVA FDA approval, Amgen can offer a much needed treatment
option to patients who suffer from giant cell tumor of bone that cannot be
adequately treated with surgery," said Sean E. Harper, M.D., executive vice
president of Research and Development at Amgen. "Advances in our understanding
of the underlying biology of this rare disorder have allowed Amgen to generate
compelling clinical evidence to address the medical needs of patients and
their healthcare providers."
XGEVA binds to RANK Ligand (RANKL), a protein essential for the formation,
function and survival of osteoclasts - the cells responsible for bone
resorption. Giant cell tumors of bone consist of stromal cells expressing
RANKL and osteoclast-like giant cells expressing RANK receptor. Signaling
through the RANK receptor contributes to osteolysis and tumor growth. XGEVA
prevents RANKL from activating its receptor, RANK, on the surface of
osteoclasts, their precursors and osteoclast-like giant cells.
About Giant Cell Tumor of Bone
GCTB is a locally aggressive, benign tumor afflicting younger adults between
the ages 20 to 40. It is estimated that there are approximately 300-800 new
cases of GCTB annually in the U.S. GCTB is unresectable in approximately 18-20
percent of cases.
Most tumors occur in the long bones of the body, often around joints, but can
also spread to the lungs in rare cases. Although giant cell tumors are slow
growing, patients can experience severe bone pain, swelling, loss of mobility
and pathologic fracture. Historically, there have been no approved therapies
for GCTB. Surgery is the main treatment option for patients with resectable
GCTB; however, surgery, such as amputation, may be associated with significant
morbidity. These tumors also have a higher recurrence rate within the first
three years of surgical intervention. When tumors recur, they become more
difficult to treat and more likely to spread to other parts of the body.
XGEVA was approved by the FDA for the prevention of skeletal-related events
(SREs) in patients with bone metastases from solid tumors in 2010. XGEVA is
not indicated for the prevention of SREs in patients with multiple myeloma. In
clinical trials, XGEVA demonstrated a clinically meaningful improvement
compared to the previous standard of care in preventing these bone
In 2013, XGEVA was approved by the FDA as the first and only treatment for
adults and skeletally mature adolescents with GCTB that is unresectable or
where surgical resection is likely to result in severe morbidity.
XGEVA Important Safety Information
XGEVA is contraindicated in patients with clinically significant
hypersensitivity to any component of the product.
XGEVA can cause severe symptomatic hypocalcemia, and fatal cases have been
reported. Correct pre-existing hypocalcemia prior to XGEVA treatment. Monitor
calcium levels and administer calcium, magnesium, and vitamin D as necessary.
Advise patients to contact a healthcare professional for symptoms of
Osteonecrosis of the Jaw (ONJ)
Osteonecrosis of the jaw (ONJ) can occur in patients receiving XGEVA. Patients
who are suspected of having or who develop ONJ while on XGEVA should receive
care by a dentist or an oral surgeon. In these patients, extensive dental
surgery to treat ONJ may exacerbate the condition.
Atypical Subtrochanteric and Diaphyseal Femoral Fracture
Atypical femoral fracture has been reported with XGEVA. Causality has not been
established as these fractures also occur in osteoporotic patients who have
not been treated with anti-resorptive agents. A number of reports note that
patients were also receiving treatment with glucocorticoids at the time of
fracture. Any patient who presents with thigh or groin pain should be
suspected of having an atypical fracture and should be evaluated to rule out
an incomplete femur fracture. Interruption of XGEVA therapy should be
considered, pending a risk/benefit assessment, on an individual basis.
XGEVA can cause fetal harm when administered to a pregnant woman. Advise
females of reproductive potential to use highly effective contraception during
therapy, and for at least 5 months after with the last dose of XGEVA.
The most common adverse reactions in patients receiving XGEVA with bone
metastasis from solid tumors were fatigue/asthenia, hypophosphatemia, and
nausea. The most common serious adverse reaction was dyspnea.
The most common adverse reactions in patients receiving XGEVA for giant cell
tumor of bone were arthralgia, headache, nausea, back pain, fatigue, and pain
in extremity. The most common serious adverse reactions were osteonecrosis of
the jaw and osteomyelitis.
Please visit www.amgen.com for full prescribing information.
Amgen discovers, develops, manufactures and delivers innovative human
therapeutics. A biotechnology pioneer since 1980, Amgen was one of the first
companies to realize the new science's promise by bringing safe, effective
medicines from lab to manufacturing plant to patient. Amgen therapeutics have
changed the practice of medicine, helping people around the world in the fight
against serious illnesses. With a deep and broad pipeline of potential new
medicines, Amgen remains committed to advancing science to dramatically
improve people's lives. For more information, visit www.amgen.com and follow
us on www.twitter.com/amgen.
This news release contains forward-looking statements that are based on
management's current expectations and beliefs and are subject to a number of
risks, uncertainties and assumptions that could cause actual results to differ
materially from those described. All statements, other than statements of
historical fact, are statements that could be deemed forward-looking
statements, including estimates of revenues, operating margins, capital
expenditures, cash, other financial metrics, expected legal, arbitration,
political, regulatory or clinical results or practices, customer and
prescriber patterns or practices, reimbursement activities and outcomes and
other such estimates and results. Forward-looking statements involve
significant risks and uncertainties, including those discussed below and more
fully described in the Securities and Exchange Commission (SEC) reports filed
by Amgen, including Amgen's most recent annual report on Form 10-K and any
subsequent periodic reports on Form 10-Q and Form 8-K. Please refer to
Amgen's most recent Forms 10-K, 10-Q and 8-K for additional information on the
uncertainties and risk factors related to our business. Unless otherwise
noted, Amgen is providing this information as of June 13, 2013, and expressly
disclaims any duty to update information contained in this news release.
No forward-looking statement can be guaranteed and actual results may differ
materially from those we project. Discovery or identification of new product
candidates or development of new indications for existing products cannot be
guaranteed and movement from concept to product is uncertain; consequently,
there can be no guarantee that any particular product candidate or development
of a new indication for an existing product will be successful and become a
commercial product. Further, preclinical results do not guarantee safe and
effective performance of product candidates in humans. The complexity of the
human body cannot be perfectly, or sometimes, even adequately modeled by
computer or cell culture systems or animal models. The length of time that it
takes for us to complete clinical trials and obtain regulatory approval for
product marketing has in the past varied and we expect similar variability in
the future. We develop product candidates internally and through licensing
collaborations, partnerships and joint ventures. Product candidates that are
derived from relationships may be subject to disputes between the parties or
may prove to be not as effective or as safe as we may have believed at the
time of entering into such relationship. Also, we or others could identify
safety, side effects or manufacturing problems with our products after they
are on the market. Our business may be impacted by government investigations,
litigation and product liability claims. If we fail to meet the compliance
obligations in the corporate integrity agreement between us and the U.S.
government, we could become subject to significant sanctions. We depend on
third parties for a significant portion of our manufacturing capacity for the
supply of certain of our current and future products and limits on supply may
constrain sales of certain of our current products and product candidate
In addition, sales of our products are affected by the reimbursement policies
imposed by third-party payers, including governments, private insurance plans
and managed care providers and may be affected by regulatory, clinical and
guideline developments and domestic and international trends toward managed
care and healthcare cost containment as well as U.S. legislation affecting
pharmaceutical pricing and reimbursement. Government and others' regulations
and reimbursement policies may affect the development, usage and pricing of
our products. In addition, we compete with other companies with respect to
some of our marketed products as well as for the discovery and development of
new products. We believe that some of our newer products, product candidates
or new indications for existing products, may face competition when and as
they are approved and marketed. Our products may compete against products that
have lower prices, established reimbursement, superior performance, are easier
to administer, or that are otherwise competitive with our products. In
addition, while we routinely obtain patents for our products and technology,
the protection offered by our patents and patent applications may be
challenged, invalidated or circumvented by our competitors and there can be no
guarantee of our ability to obtain or maintain patent protection for our
products or product candidates. We cannot guarantee that we will be able to
produce commercially successful products or maintain the commercial success of
our existing products. Our stock price may be affected by actual or perceived
market opportunity, competitive position, and success or failure of our
products or product candidates. Further, the discovery of significant
problems with a product similar to one of our products that implicate an
entire class of products could have a material adverse effect on sales of the
affected products and on our business and results of operations.
The scientific information discussed in this news release relating to new
indications for our products is preliminary and investigative and is not part
of the labeling approved by the U.S. Food and Drug Administration (FDA) for
the products. The products are not approved for the investigational use(s)
discussed in this news release, and no conclusions can or should be drawn
regarding the safety or effectiveness of the products for these uses. Only
the FDA can determine whether the products are safe and effective for these
uses. Healthcareprofessionals shouldrefer to and rely upon the FDA-approved
labeling for the products, and not the information discussed in this news
CONTACT: Amgen, Thousand Oaks
Christine Regan, 805-447-5476 (media)
Arvind Sood, 805-447-1060 (investors)
Press spacebar to pause and continue. Press esc to stop.