Amgen And AstraZeneca Highlight Data To Be Presented At European League Against Rheumatism Annual Meeting

   Amgen And AstraZeneca Highlight Data To Be Presented At European League
                      Against Rheumatism Annual Meeting

PR Newswire

THOUSAND OAKS, Calif. and GAITHERSBURG, Md., June 12, 2013

THOUSAND OAKS, Calif. and GAITHERSBURG, Md., June 12, 2013 /PRNewswire/ --
Amgen (NASDAQ:AMGN) and AstraZeneca (AZN), with its biologics research and
development arm MedImmune, today announced that they will present data from a
Phase 2 study evaluating brodalumab, a human monoclonal antibody targeting the
IL-17 receptor, being investigated for the treatment of psoriatic arthritis at
the 2013 European League Against Rheumatism (EULAR) Annual Meeting
inMadrid,June 12-15, 2013.

"The brodalumab data being presented at EULAR demonstrate a positive
benefit-risk profile for patients with psoriatic arthritis," said Sean E.
Harper, M.D., executive vice president of Research and Development at Amgen.
"We are encouraged by these data as we continue to explore brodalumab for its
potential to treat patients with inflammatory disease including psoriatic

Based on the Phase 2 results, the companies intend to advance brodalumab into
Phase 3 clinical studies for the treatment of psoriatic arthritis in 2014.

"This brodalumab data marks a positive step forward for patients with
psoriatic arthritis," said Dr. Bahija Jallal, executive vice president,
MedImmune. "We look forward to working with Amgen to further evaluate this
novel therapy in psoriatic arthritis and potentially other chronic
immune-mediated diseases."


Brodalumab Abstract at EULAR:

  oEfficacy of Brodalumab, an Anti-IL-17R Antibody, in Subjects with
    Psoriatic Arthritis
    Abstract No. OP0103, Oral Presentation, Thursday, June 13, 10:20 a.m. CET,

Abstracts are currently available on the EULAR website at

About Brodalumab

Brodalumab is a highly-selective human monoclonal antibody that binds to and
blocks signaling via the IL-17 receptor. The IL-17 pathway plays an important
role in inducing and promoting inflammatory disease processes.

Brodalumab is the first investigational treatment in development that blocks
the IL-17receptor, thereby blocking several of the IL-17 ligands at once. By
stopping IL-17 ligands from binding to the receptor, brodalumab prevents the
body from receiving signals that may lead to inflammation and other ailments.
At this time, other agents in development seek to target a single

In addition to psoratic arthritis, brodalumab is currently being investigated
for the treatment of psoriasis (Phase 3) and asthma (Phase 2).

About Psoriatic Arthritis

Psoriatic arthritis is a chronic disease of the immune system that causes
joint pain, stiffness and swelling which can become progressively worse over
time, and may also include red patches of skin topped with silvery scales.^1

The progressive joint damage, pain and swelling coupled with painful, scaly,
red skin patches can disrupt a person's ability to perform daily activities,
such as using their hands, standing for long periods or walking.^2 Psoriatic
arthritis affects 30 to 50 percent^3 of the approximate 125 million people
worldwide who have psoriasis.^4

About Amgen

Amgen discovers, develops, manufactures and delivers innovative human
therapeutics. A biotechnology pioneer since 1980, Amgen was one of the first
companies to realize the new science's promise by bringing safe, effective
medicines from lab to manufacturing plant to patient. Amgen therapeutics have
changed the practice of medicine, helping people around the world in the fight
against serious illnesses. With a deep and broad pipeline of potential new
medicines, Amgen remains committed to advancing science to dramatically
improve people's lives. For more information, visit and follow
us on

About AstraZeneca

AstraZeneca is a global, innovation-driven biopharmaceutical business that
focuses on the discovery, development and commercialisation of prescription
medicines, primarily for the treatment of cardiovascular, metabolic,
respiratory, inflammation, autoimmune, oncology, infection and neuroscience
diseases. AstraZeneca operates in over 100 countries and its innovative
medicines are used by millions of patients worldwide. For more information
please visit:

Amgen Forward-Looking Statements

This news release contains forward-looking statements that are based on
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The scientific information discussed in this news release related to our
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Healthcareprofessionals shouldrefer to and rely upon theFDA-approved
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Amgen, Thousand Oaks
                                      Tracy Rossin, 301-398-1468 (media)
Ashleigh Koss, 805-313-6151 (media)
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                                      Ed Seage 302-886-4065 (investors)


^1Krueger, Gerald G., MD. Clinical Features of Psoriatic Arthritis. The
American Journal of Managed Care. 2002; 8:160-170
^2Krueger G, Koo J, Lebwohl M, et al. The Impact of Psoriasis on Quality of
Life: Results of a 1998 National Psoriasis Foundation Patient-Membership
Survey. Arch Dermatol. 2001; 137:280-4
^3International Federation of Psoriasis Associations, Important facts about
^4About Psoriasis: Statistics. National Psoriasis Foundation.




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