TRADE NEWS: Agilent Technologies Introduces Comprehensive Reference Guide
for GC/MS/MS Pesticide Analysis
Guide Covers the Latest Food Testing Methods and Technology
SANTA CLARA, Calif. -- June 11, 2013
Agilent Technologies Inc. (NYSE: A) today introduced the GC/MS/MS Pesticide
Residue Analysis Guide, a comprehensive reference developed by Dr. Katerina
Mastovska, the head of Excellcon International, LLC., in collaboration with
scientists from the California Department of Food and Agriculture, the Florida
Department of Agriculture and Consumer Services, and Agilent.
The detailed compendium outlines complete instructions for modifying and
re-optimizing analytical methodology and standard operating procedures for
analyzing pesticide residue in food. The compendium has also been successfully
applied to pesticide GC/MS/MS analysis in drinking water at a state
The guide features a complete spectrum of resources for GC/MS/MS analysis, a
companion sample preparation procedure, and instructions for expanding
analytical methods using the Agilent Pesticide and Environmental Pollutant MRM
Participants in this week’s conference of the American Society of Mass
Spectrometry in Minneapolis may receive copies of the guide and speak to
Agilent scientists at Booth 109, or visit the Agilent Hospitality Suite in the
evenings. Interested parties not attending the conference may contact their
local Agilent representative to obtain copies.
“This guide is an excellent resource that provides laboratories with thorough
instruction on pesticide analysis methodologies and delineates which
pesticides are amenable to GC/MS/MS or to LC/MS/MS—or both—and also includes
notes on how to address the most challenging pesticides,” said Raymond Allum,
environmental manager at Florida’s Department of Agriculture Bureau of
Chemical Residue Laboratories. “This method has proven to be robust and
reliable, yielding excellent results across a wide variety of food matrices.”
“Analysts are confronted with a number of options when it comes to QuEChERS
modifications, calibration approaches, matrix-related issues and instrumental
conditions,” said Melissa Churley, Agilent’s senior applications scientist.
“Add to this, the question of GC or LC suitability for a subset of the
complete list of analytes and the number of variables becomes almost
insurmountable in terms of achieving a widely applicable, rugged GC-MS/MS
method. Dr. Mastovska’s recommended core method has proved to be a turnkey
solution for a number of customers in the U.S. in that it was easily
implemented within a few days. We believe this will be the case for many
“Food, water and environmental safety regulations have never been more
stringent, which means the onus lies squarely on laboratories to optimize
their screening tools and procedures to ensure the validity and reliability of
their results,” said Terry Sheehan, Agilent’s director of GC/MS marketing.
“The good news is that there are highly sophisticated technologies available
today to help them accomplish that feat.
“This valuable guide provides laboratories with a complete resource for
identifying which of those technologies best fulfills their needs and how to
develop rigorous testing methods to detect pesticides at the lowest levels
possible, and obtain results with more confidence and speed than ever before.”
The new GC/MS/MS Pesticide Residue Analysis Guide provides a recommended
rugged GC/MS/MS method for pesticide multi-residue analysis using an Agilent
7000 Triple Quadrupole GC/MS. The guide also includes practical tips and
considerations for method development, optimization, modification and routine
It discusses important aspects associated with GC and MS/MS analysis of
pesticides, especially when dealing with matrix-related issues, which are
largely affected by the chemical composition of the sample extract. For this
reason, the guide also covers the basics of sample preparation in pesticide
multi-residue analysis with the focus on the QuEChERS (Quick, Easy, Cheap,
Effective, Rugged, and Safe) approach for which a recommended procedure is
Contents of Guide
*Multi-residue pesticide analysis overview
*QuEChERS history, modifications and cleanup options
*Use of internal quality/process control standards
*GC analysis of pesticides (matrix effects, injection techniques,
calibration approaches, analyte protectants and column back-flushing)
*MS/MS detection considerations
*GC/MS/MS method development and optimization
*Method modifications for additional analytes
*Tables GC/MS/MS- vs. LC/MS/MS-amenable pesticides and pesticides requiring
special consideration when using QuEChERS
*Example GC/MS/MS method standard operating procedure
*Example companion QuEChERS protocol, including reagent solution
The GC/MS/MS Pesticide Residue Analysis reference guide is part of Agilent’s
comprehensive mass spectrometry portfolio, which includes powerful GC/MS,
LC/MS, and ICP-MS solutions for a variety of diverse applications.
About the Bureau of Chemical Residue Laboratories
The Bureau of Chemical Residue Laboratories in the Division of Food Safety,
Florida Department of Agriculture and Consumer Services is responsible for the
chemical analysis of poisonous or deleterious chemical residues remaining in
or on human food produced or marketed in Florida, as well as for the
regulatory enforcement of federal pesticide and antibiotic residue tolerances
and guidelines adopted by the state for raw agricultural produce.
About Agilent Technologies
Agilent Technologies Inc. (NYSE: A) is the world’s premier measurement company
and a technology leader in chemical analysis, life sciences, diagnostics,
electronics and communications. The company’s 20,500 employees serve customers
in more than 100 countries. Agilent had revenues of $6.9 billion in fiscal
2012. Information about Agilent is available at www.agilent.com.
NOTE TO EDITORS: Further technology, corporate citizenship and executive news
is available at www.agilent.com/go/news.
Agilent Technologies Inc.
Susan Berg, +1 408-553-7093
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