Teprotumumab Restarts Clinical Development in New Indication
*Teprotumumab (RG1507) to be investigated for new indication
*River Vision Development Corporation to conduct clinical development under
a license from Roche
COPENHAGEN, Denmark, June 11, 2013 (GLOBE NEWSWIRE) -- Genmab A/S
(Copenhagen:GEN) announced today that teprotumumab (RG1507), an antibody
developed by Genmab under our collaboration with Roche, will restart clinical
development in a Phase 2 study in patients with active thyroid eye disease.
Clinical development will be conducted by River Vision Development
Corporation, who licensed teprotumumab from Roche.
"In drug development, it's often possible to take what was learned about a
product in its initial development and apply it to new indications. We are
pleased that River Vision will resume clinical development of teprotumumab for
the potential treatment of ophthalmic conditions," said Jan van de Winkel,
Ph.D., Chief Executive Officer.
Under our collaboration with Roche, Genmab will receive milestones as well as
royalty payments on successful products.
River Vision Development Corporation is a private company focused on
Today's news does not affect Genmab's financial guidance for 2013.
Teprotumumab is a fully human antibody that targets the Insulin-like Growth
Factor-1 Receptor (IGF-1R) which is a well validated target. Teprotumumab was
previously investigated in various cancer indications.
About Genmab A/S
Genmab is a publicly traded, international biotechnology company specializing
in the creation and development of differentiated human antibody therapeutics
for the treatment of cancer. Founded in 1999, the company's first marketed
antibody, ofatumumab (Arzerra(r)), was approved to treat chronic lymphocytic
leukemia in patients who are refractory to fludarabine and alemtuzumab after
less than eight years in development. Genmab's validated and next generation
antibody technologies are expected to provide a steady stream of future
product candidates. Partnering of innovative product candidates and
technologies is a key focus of Genmab's strategy and the company has alliances
with top tier pharmaceutical and biotechnology companies. For more
information visit www.genmab.com.
Rachel Curtis Gravesen, Senior Vice President, Investor Relations &
T: +45 33 44 77 20; M: +45 25 12 62 60; E: firstname.lastname@example.org
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Company Announcement no. 28
CVR no. 2102 3884
1260 Copenhagen K
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