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News Release 
Your Contact
Phyllis Carter
+49 6151 72-7144 
Merck: Detailed Results of Phase III Trial of L-BLP25 in Patients With
Non-Small Cell Lung Cancer (START) to be Presented at ASCO 
• Confirmed: Primary endpoint of significantly improving overall survival
• Predefined subgroup of patients receiving initial concurrent
 chemoradiotherapy: median overall survival of 30.8 months observed in
 patients treated with L-BLP25 compared to 20.6 months in patients
 placebo (HR 0.78, p=0.016) in post hoc analysis
• Detailed results to be presented on Tuesday, June 4 
Darmstadt, May 16, 2013 – Merck announced today detailed results from the
randomized Phase III START* trial of its investigational MUC1
antigen-specific cancer immunotherapy L-BLP25 (formerly referred to as
Stimuvax) in patients with unresectable, locally advanced Stage III
non-small cell lung cancer (NSCLC). These results will be presented at the
American Society of Clinical Oncology (ASCO) 2013 Annual Meeting in
Chicago. The primary endpoint of improving overall survival (OS) was not
met. In a predefined subgroup of patients receiving initial concurrent
chemoradiotherapy (CRT), a combination of chemotherapy and radiotherapy
given at the same time, a median overall survival of 30.8 months versus
20.6 months was observed based on a post hoc analysis in patients treated
with L-BLP25 versus placebo respectively (HR 0.78, 95% CI 0.64–0.95,
p=0.016, n=806). The results of the START trial will be presented during
the Oral Abstract Session “Lung Cancer – Non-Small Cell Local-Regional /
Small Cell / Other Thoracic Cancers” from 09.45 am to 12.45 pm on Tuesday,
June 4. 
The complete news release can be downloaded at the following link:$File/Start_Asco_engli
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Merck KGaA ,Darmstadt, Germany
External Communications
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