PerkinElmer Introduces New Chemical Intelligence Capabilities for Accelerating the Lead Discovery Process

  PerkinElmer Introduces New Chemical Intelligence Capabilities for
  Accelerating the Lead Discovery Process

   Lead Discovery for TIBCO Spotfire^® Software Provides Extensive Chemical
                                  Structure

       Searching & Visualization for Finding Promising Compounds Faster

Business Wire

NEWTON, Mass. -- May 08, 2013

PerkinElmer, Inc., a global leader focused on improving the health and safety
of people and the environment, is introducing the newest version of Lead
Discovery for the TIBCO Spotfire^® software platform at the Company’s
Revolutionaries for Global Health Summit. The new functionality of Lead
Discovery 5.1 combined with the TIBCO Spotfire^® software’s advanced data
visualization and analysis capabilities bring a new level of chemical
intelligence to the informatics platform for advanced scientific discovery.

Lead Discovery 5.1 offers interactive tools for structure searching, activity
profiling, R-group dec ...

Lead Discovery 5.1 offers interactive tools for structure searching, activity
profiling, R-group decomposition, clustering on properties/structural
descriptors and list management. This example shows R-Group decomposition
based on a common scaffold computed through the native chemistry algorithms in
Lead Discovery 5.1. (Photo: Business Wire)

PerkinElmer’s Lead Discovery^™ 5.1 enhances the TIBCO Spotfire^® software data
analysis capabilities with new functionality built specifically with chemists
in mind. Based on PerkinElmer’s industry-leading ChemDraw^® drawing tool, the
chemical intelligence in Lead Discovery provides scientists using TIBCO
Spotfire® software with extensive chemical structure searching and
visualization. Now scientists are able to dynamically filter their
experimental data sets by chemical structure and pinpoint promising structural
features and scaffolds in the output from their medicinal and combinatorial
chemistry programs. The new technology enables users to mine their chemical
databases to identify more compounds that have similar chemical structures,
broadening their potential pool of candidates based on known properties and
shortening their time to discovery of a viable candidate or lead.

“Through our relationship with TIBCO we are able to expand the range and depth
of the TIBCO Spotfire® platform to serve the rapidly evolving needs of the
scientific research community,” said Michael Stapleton, general manager,
PerkinElmer Informatics. “With Lead Discovery 5.1, chemists will be able to
explore their data sets in the context of visual chemical structures and as a
result quickly filter to find the chemical compounds that are most promising
to them. This capability will help them gain the critical insights they need
to accelerate decisions on which compounds to pursue, while significantly
reducing many of the typical technical bottlenecks to understanding data.”

In addition to dynamic, structure-based filtering, another key functionality
of Lead Discovery 5.1 is that it automatically analyzes and displays R-groups
(group side chains in chemical structure diagrams) or substituent variations
on similar chemical scaffolds. These chemical variations have significant
impact on dose response and side effects as they affect how the molecule
interacts with a target. Using the new informatics tool, scientists can
quickly isolate the variables to identify and optimize promising compound
candidates.

“I foresee Lead Discovery becoming a heavily utilized aspect of our discovery
scientists’ use of the TIBCO Spotfire^® software,” said Dr. Daniel C. Weaver,
manager of scientific computing at Array BioPharma Inc. “The capability to
perform structure filtering and R-group analysis in real time will help drive
compound series prioritization and structure activity relationship (SAR)
analysis. This is critical to narrowing down the range of compounds that we
are evaluating and helps to accelerate our ability to find the most promising
candidates for our research.”

The Revolutionaries for Global Health Summit is PerkinElmer’s annual forum for
leading researchers and physicians to network and share best practices in both
science and business and participate in cutting-edge discussions to help lead
to better prevention, detection and treatment of disease. At the Summit,
several important presentations will be made by renowned users of the TIBCO
Spotfire® software, and a hands-on workshop will allow attendees to learn how
the software can impact their own research.

PerkinElmer leverages its deep scientific knowledge and expertise in the
development of the most comprehensive suite of scientific informatics and
software solutions - from instrument generated data, to enterprise solutions
to mobile applications. Built by scientists for scientists, PerkinElmer’s
integrated business-wide information management system provides companies and
academic institutions with the necessary tools to aggregate, search, mine,
analyze and visualize critical data so that they can turn data into actionable
insights in an automated, predictive and scalable way. For more information,
visit www.perkinelmer.com/informatics.

About PerkinElmer

PerkinElmer, Inc. is a global leader focused on improving the health and
safety of people and the environment. The company reported revenue of
approximately $2.1 billion in 2012, has about 7,500 employees serving
customers in more than 150 countries, and is a component of the S&P 500 Index.
Additional information is available through 1-877-PKI-NYSE, or at
www.perkinelmer.com.

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Contact:

Edelman (on behalf of PerkinElmer)
Paul Barren, 404-460-9679
Paul.barren@edelman.com