SHIRE PLC: Transaction in Own Shares

Transaction in Own Shares 
May 7, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company"), announces
that in accordance with the authority granted by shareholders at the Company's
Annual General Meeting on April 30, 2013 it purchased 220,000 of its ordinary
shares of 5 pence each ("Ordinary Shares") on May 3, 2013. The highest and
lowest price paid for the directly acquired Ordinary Shares was 1884.00 pence
per share and 1855.00 pence per share respectively. 
The purchased shares will be held as treasury shares. Following the above
purchase, the Company holds 8,204,097 Ordinary Shares as treasury shares and
has 554,622,325 Ordinary Shares in issue (excluding treasury shares). 
The purchases were made by an independent third party which makes its trading
decisions independently of, and uninfluenced by the Company.  The independence
of the third party enables the Company to continue to purchase Ordinary Shares
during close periods and other prohibited periods, should they arise. The third
party has been appointed by the Company to make purchases to December 31, 2013. 
For further information please contact: 
Investor Relations                                                              
                                                                           
Eric Rojas                              erojas@shire.com     +1 781 482 0999    
                                                                           
Sarah Elton-Farr                        seltonfarr@shire.com +44 1256 894157    
NOTES TO EDITORS 
Shire enables people with life-altering conditions to lead better lives. 
Our strategy is to focus on developing and marketing innovative specialty
medicines to meet significant unmet patient needs. 
We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal,
Internal Medicine and Regenerative Medicine and we are developing treatments
for symptomatic conditions treated by specialist physicians in other targeted
therapeutic areas. 
www.shire.com 
                                                                           
Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX 
                                                                          
Press Release                                      
                                              
www.shire.com 
-0- May/07/2013 06:01 GMT