Mounting Body of Research on Cranberry Bioactives Further Supports the Fruit’s Whole Body Health Benefits

  Mounting Body of Research on Cranberry Bioactives Further Supports the
  Fruit’s Whole Body Health Benefits

 New data suggest cranberry polyphenols, including proanthocyanidins (PACs),
offer wide range of benefits from urinary tract and immune function support to
                      improved cardiometabolic profiles

Experimental Biology 2013

Business Wire

LAKEVILLE-MIDDLEBORO, Mass. -- April 26, 2013

Research presented at this week’s Experimental Biology 2013 conference
indicates the power of cranberries is broader than previously thought. Several
new studies demonstrate the health benefits of cranberry’s chief bioactives,
proanthocyanidins (PACs), and other polyphenols on a wide variety of cell
types within the human body and point to the exceptional benefit of cranberry
PACs in multiple forms, including juice, dried and supplemented powder
beverage.

From urinary tract and immune function support to improved cardiometabolic
profiles, new research pr ...

From urinary tract and immune function support to improved cardiometabolic
profiles, new research presented at this week's Experimental Biology 2013
supports the cranberry's whole body health benefits. For more information,
visit www.cranberryhealth.com. (Photo: Business Wire)

“The body of evidence supporting health benefits from phytonutrients is
rapidly mounting,” said Jeffrey Blumberg, PhD, Director, Antioxidants Research
Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts
University. “It is time to clearly identify the cranberry bioactives at work
and to quantify how many milligrams of PACs and polyphenols we need in a day.
We may not have a clear recommended daily allowance for PACs like we have for
vitamin C, for example, but we should press ahead to a better understanding of
their mechanisms and the amount needed in a day for overall better health.”

Professor Blumberg was among the speakers at an Ocean Spray sponsored dinner
preceding the conference which brought together members of the scientific and
health communities to discuss the wide range of cranberry health benefits and
implications for the upcoming 2015 Dietary Guidelines for Americans.

Cardiometabolic Health

Among the studies highlighted at the conference and the preceding event was
emerging research linking consumption of cranberry juice cocktail (CJC) to
better cardiometabolic profiles.^1 An observational study conducted in
collaboration with the University of North Carolina using the CDC National
Health and Nutrition Examination Survey (NHANES) data found that adolescents
(ages 12-18 years) and adults (19+ years of age) who drink an average of two
glasses (14 fl. oz.) over two non-consecutive days have better cardiometabolic
profiles than those who do not consume CJC. In this study, adolescent and
adult CJC consumers had significantly higher intakes of total polyphenols and
proanthocyanidins from drinking CJC, which have proven health-promoting
benefits. Each group also demonstrated significantly lower body weight and
waist circumference, were less likely to be overweight and demonstrated lower
odds of having high C-reactive protein levels, a marker of inflammation.
Additionally, adolescent CJC consumers demonstrated significantly lower
fasting glucose and better lipid profiles, including lower odds of high total
cholesterol and high LDLs, indicating that while CJC must be sweetened to be
palatable, it can be part of a healthy lifestyle with a potential positive
effect on overall cardiometabolic health.

“These health benefits may be due to higher polyphenol intake from the
cranberry bioactives,” said Lisa Sutherland, PhD, Principal, LA Sutherland
group, who led the observational study. “While these data are preliminary, we
believe something as simple as adding a serving of cranberry juice cocktail to
the diet could help support a healthy lifestyle.”

In a double blind placebo controlled randomized trial presented at American
Heart Association meetings last year by researchers at USDA Human Nutrition
Center at Beltsville, consumption of a low calorie CJC also resulted in
significant lowering of the C reactive protein in the group drinking CJC
compared to placebo.^2 Both studies, the randomized clinical trial and the
observational study, clearly support each other’s findings.

Tied closely to these findings, another study investigates the polyphenolic
content of CJC compared to sweetened dried cranberries.^3 This research finds
CJC has about 35 mg PACs (per 240 milliliter serving) and sweetened dried
cranberries have 38 mg PACs (per 40 gram serving), suggesting the two forms –
juice and dried – offer nearly equivalent levels of the cranberry bioactive.

“We are excited by these findings, because they suggest people who enjoy
cranberry juice cocktail, sweetened dried cranberries, or a mix of the two
forms on a regular basis can experience the same apparent benefits of a higher
polyphenolic diet,” said Christina Khoo, PhD, Ocean Spray.

Urinary Tract Health

Further findings presented this week confirm the cranberry’s urinary tract
health benefits. A new study conducted in collaboration with Rutgers
University found that a polyphenol rich cranberry powder offers the same
bacterial anti-adhesion effect as CJC, suggesting that polyphenol bioactives
are important in preventing unwanted pathogens, like Escherichia coli, from
entering cells in the bladder.^4 This effect is thought to contribute to
urinary tract health, potentially translating to fewer urinary tract
infections, which are believed to cost patients $500 million in prescription
drug costs each year.

Immunity

Rounding out the research at this week’s conference were findings supporting
the growing body of research linking cranberry consumption to improved
immunity. Research from Susan Percival, PhD, and her team at the University of
Florida, Gainesville, confirms that cranberry PACs and polyphenols interact
with pathogen recognition receptors on innate immune cells.^5 The results of
the study suggest that cranberry PACs activate a signaling pathway that
ultimately allows for an enhanced response to an immune challenge.

Additionally, two studies from the University of Wisconsin scientists provide
further evidence that cranberry bioactives not only play an important role in
supporting immune function,^6 but also provide more insight on how these
compounds prevent bacterial adhesion and infection of cells in the gut.^7 In
the first study, the researchers provided cranberry powder to 10 human study
participants for one week. The study results suggest that the cranberry
powder– amounting to 38 mg PAC equivalents per day – has a meaningful impact
on the urinary proteins profile. Specifically, the supplementation resulted in
the statistically significant lowering of eight urinary peptides tied to
regulation of immune responses and tumorigenesis.^8 In the cell study,
treatment of cells with cranberry actives resulted in an inhibition of the
ability of the uropathogenic bacteria to invade the cells, potentially leading
to decreased number of uropathogens that can infect the body.^9

“Ultimately, from in vitro to epidemiological and clinical evidence, we
continue to have new and emerging data pointing towards the exceptional
ability of cranberries to support whole body health,” added Dr. Khoo. “There
are significant opportunities to move forward the discussion around cranberry
polyphenols’ contribution to health, and we’re confident that this type of
research and dialogue will continue to support our long-term hypothesis that
cranberries are an important part of a daily balanced diet and healthy
lifestyle.”

For more information about the whole body health benefits of cranberries or to
review the abstracts highlighted above, visit www.cranberryhealth.com.

About Ocean Spray

Ocean Spray is a vibrant agricultural cooperative owned by more than 700
cranberry and grapefruit growers in the United States, Canada, and Chile who
have helped preserve the family farming way of life for generations. Formed in
1930, Ocean Spray is now the world’s leading producer of cranberry juices,
juice drinks and dried cranberries, and is the best-selling brand in the
bottled juice category. The cooperative’s cranberries are currently featured
in more than 1,000 great-tasting, good-for-you products in over 50 countries
worldwide. With more than 2,000 employees and nearly 20 cranberry receiving
and processing facilities, Ocean Spray is committed to managing our business
in a way that respects our communities, employees and the environment. In
fiscal year 2012, Ocean Spray posted record-high gross sales of $2.2 billion
and net proceeds of $338 million.

^1 Duffey, K., Sutherland, L.A. and Khoo, C., (2013) Cranberry juice cocktail
consumers have healthier cardio-metabolic profiles. FASEB J. 27, 359.8

^2 Novotny, J.A., Baer, D.J., Khoo, C. and Gebauer, S.K., (2012) Low Calorie
Cranberry Juice Lowers Blood Pressure in Healthy Adults. Hypertension. 60,
A299

^3 Marais, J. and Khoo, C., (2013) Polyphenolic content of sweet dried
cranberries compared to cranberry juice cocktail. FASEB J. 27, 1079.19

^4 Kaspar, K.L., Howell, A.B. and Khoo, C., (2013) Ex vivo anti-adhesion
activity of a proanthocyanidin standardized cranberry powder beverage. FASEB
J. 27, 1079.42

^5 Creasy, R.A., Khoo, C. and Percival, S.S., (2013) Cranberry bioactives
induce TLR signaling and promote a state of immune preparedness in THP-1
monocytes/macrophages. FASEB J. 27, 637.29

^6 Krueger, C.G., Meudt, J.J., Howell, A.B., Khoo, C. and Shanmuganayagam, D.,
(2013) Consumption of cranberry powder shifts urinary protein profile in
healthy human subjects. FASEB J. 27, 637.32

^7 Shanmuganayagam, D., Johnson, R.E. Meudt, J.J., Feliciano, R.P., Kohlmann,
K.L., Nechyporenko, A.V., Heintz, J.A., Krueger, C.G. and Reed, J.D., (2013)
A-type proanthocyanidins from cranberry inhibit the ability of extraintestinal
pathogenic E. coli to invade gut epithelial cells and resist killing by
macrophages. FASEB J. 27, 637.16

^8 Krueger, C.G., Meudt, J.J., Howell, A.B., Khoo, C. and Shanmuganayagam, D.,
(2013) Consumption of cranberry powder shifts urinary protein profile in
healthy human subjects. FASEB J. 27, 637.32

^9 Shanmuganayagam, D., Johnson, R.E. Meudt, J.J., Feliciano, R.P., Kohlmann,
K.L., Nechyporenko, A.V., Heintz, J.A., Krueger, C.G. and Reed, J.D., (2013)
A-type proanthocyanidins from cranberry inhibit the ability of extraintestinal
pathogenic E. coli to invade gut epithelial cells and resist killing by
macrophages. FASEB J. 27, 637.16

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Contact:

Weber Shandwick for Ocean Spray
Rachel Walt, 617-520-7254
rwalt@webershandwick.com