Research shows that superbugs are killed by ACTICOAT™ silver-coated antimicrobial dressings

Research shows that superbugs are killed by ACTICOAT™ silver-coated 
antimicrobial dressings 
ST. PETERSBURG, Fla., April 9, 2013 /CNW/ - Smith & Nephew (LSE: SN, NYSE: 
SNN), the global medical technology business, today announced in-vitro study 
results suggesting ACTICOAT Silver-Coated Antimicrobial Dressings are 
bactericidal against some antibiotic resistant organisms carrying the NDM-1 
enzyme, often referred to as 'superbugs'. 
An in-vitro laboratory study showed ACTICOAT Dressings, containing patented 
Nanocrystalline Silver technology, can kill the antibiotic resistant enzyme, 
New Delhi metallo-beta-lactamase 1 (NDM-1 bacteria strain)(3) which is carried 
by four of the same CRE bacteria cited by the CDC1. In this study, ACTICOAT 
Dressings killed Escherichia coli and Klebsiella spp.,(3) which are 
responsible for most carbapenem resistance in the United States(1). 
The Centers for Disease Control (CDC) issued statements recently to warn the 
public about antibiotic resistant organisms like carbapenem-resistant 
Enterobacteriaceae (CRE), raising concerns about the rise in the prevalence of 
these organisms and their associated high mortality rates(1). While the 
prevalence of CRE varies by geographic region, CRE organisms can spread their 
resistant genes to common bacteria, potentially resulting in the spread of 
untreatable infections. 
Reducing the spread of CRE is challenging for hospitals, rehabilitation 
facilities and nursing homes because these antibiotic resistant bacteria 
develop resistance to even the most powerful antibiotics which are often 
reserved as a last resort. According to the CDC, almost all CRE infections 
happen to patients who are receiving serious medical care(2). 
Dr. Jose Vazquez, MD, FACP, FIDSA, Professor of Medicine, Division of 
Infectious Diseases, Wayne State University School of Medicine, Senior Staff, 
Henry Ford Hospital, Detroit, MI uses ACTICOAT Dressings in his practice. He 
says: "Any opening in the skin provides an entry point for antibiotic 
resistant organisms. I use ACTICOAT Dressings in my practice because they 
provide an antimicrobial barrier that helps protect wounds and incision sites 
from external contamination. I continue to see excellent clinical results 
because ACTICOAT Dressings are bactericidal against five strains of bacteria 
that carry the NDM-1 enzyme and 360+ pathogens including 188 strains of MRSA." 
The Nanocrystalline Silver in ACTICOAT Dressings is different from the silvers 
used in other dressings because of its potency, fast kill action of 30 
minutes, and broad spectrum activity. ACTICOAT provides bactericidal activity 
for up to seven days, so it helps protect patients with wounds or incisions 
from environmental contamination, even after they leave the hospital. ACTICOAT 
is contra-indicated in patients with known hypersensitivity to any of the 
components of the product. (If signs of a sensitivity reaction develop during 
use, treatment should be discontinued.) 
"We share the same concerns as the CDC about antibiotic resistant organisms 
and are pleased that ACTICOAT Dressings are bactericidal against five 
different strains of bacteria that carry NDM-1 carbapenemases," said Tom 
Dugan, President, North America, Advanced Wound Management division, Smith & 
Nephew. "Making this information widely available is part of our obligation to 
address public health issues and support clinicians and the patients they 
serve, helping them to reduce the human and economic costs of wounds." 
For more information about Smith & Nephew, please visit www.smith-nephew.com. 
References  1) CDC 2012 CRE Toolkit. Guidance for Control of 
Carbapenem-resistant Enterobacteriaceae.  2) CDC Vital Signs™ Report, March 
2013 3) Hope et al. (2012) The In-Vitro antibacterial activity of 
nanocrystalline silver dressings against bacteria with NDM-1 carbapenemase. 
Presented at European Wound Management Association Conference. Vienna. 
About Smith & Nephew 
Smith & Nephew is a global medical technology business dedicated to helping 
improve people's lives. With leadership positions in Orthopaedic 
Reconstruction, Advanced Wound Management, Sports Medicine and Trauma, Smith & 
Nephew has almost 10,500 employees and a presence in more than 90 countries. 
Annual sales in 2012 were more than $4.1 billion. Smith & Nephew is a member 
of the FTSE100 (LSE: SN, NYSE: SNN). 
For more information about Smith & Nephew, please visit: www.smith-nephew.com 
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CO: Smith & Nephew
ST: Florida
NI: HEA MTC ECOSURV  
-0- Apr/09/2013 11:01 GMT