Synta Announces Presentations at the 2013 Annual Meeting of the American Association of Cancer Research

  Synta Announces Presentations at the 2013 Annual Meeting of the American
  Association of Cancer Research

Business Wire

LEXINGTON, Mass. -- April 5, 2013

Synta Pharmaceuticals Corp. (NASDAQ: SNTA) announced today that poster
presentations related to studies with ganetespib, a selective Hsp90 inhibitor
in clinical development by the company, will be presented at the 2013 Annual
Meeting of the American Association of Cancer Research in Washington, D.C.
Presentations include:

Inhibition of mTOR enhances the activity of HSP90 inhibitors in part through
cessation of heat shock protein synthesis

Presentation: Sunday, April 7, 1:00 - 5:00 PM ET
Abstract number: 1038
Authors: He, et al.

Ultra-deep sequencing of circulating free DNA to identify predictive, mutated
HSP90 clients in the GALAXY Trial (NCT01348126): a randomized phase IIB/III
study of ganetespib (STA-9090) in combination with docetaxel versus docetaxel
alone in subjects with stage IIIb/IV NSCLC

Presentation: Monday, April 8, 1:00 - 5:00 PM ET
Abstract number: 2012
Authors: Fennell, et al.

The importance of dose schedule with HSP90 inhibitors: Results from a Phase II
study in dogs with mast cell tumors

Presentation: Tuesday, April 9, 8:00 AM - 12:00 PM ET
Abstract number: 3369
Authors: London, et al.

Differential sensitivities to heat shock protein 90 (HSP90) inhibitors in
anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC)
cells

Presentation: Tuesday, April 9, 8:00 AM - 12:00 PM ET
Abstract number: 3272
Authors: Lee, et al.

Heat shock protein 90 functional inhibition regulates epithelial to
mesenchymal transformation, invasion and migration via NF-kB and HIF-1α
signaling in colorectal cancer

Presentation: Tuesday, April 9, 8:00 AM - 12:00 PM ET
Abstract number: 2707
Authors: Ganji, et al.

About Ganetespib

Ganetespib is an inhibitor of heat shock protein 90 (Hsp90) that is
structurally unrelated to first-generation, ansamycin-related Hsp90
inhibitors. In preclinical experiments, ganetespib has shown activity in
multiple tumor models both as a single agent and in combination with certain
widely used cancer agents. Company-sponsored clinical studies with ganetespib
include 1) the randomized GALAXY-1 and GALAXY-2 trials evaluating ganetespib
in combination with docetaxel as second-line treatment of non-small cell lung
cancer (NSCLC), 2) the CHIARA Phase 2 trial evaluating ganetespib monotherapy
in ALK+ NSCLC, and 3) the ENCHANT Phase 2 trial evaluating ganetespib as
first-line treatment for HER2+ and triple-negative metastatic breast cancer.
In addition, ganetespib is being evaluated in investigator-sponsored trials
for treatment of a number of solid tumor and hematologic cancer indications.
Information on these trials can be found at www.clinicaltrials.gov.

The safety profile of ganetespib has been favorable in over 700 patients
treated to date in more than 20 clinical trials. Transient, mild or moderate
diarrhea has been the most commonly reported adverse event.

About Hsp90

Hsp90 is a molecular chaperone required for the proper folding and activation
of many cancer-promoting proteins, and is recognized as a key facilitator of
cancer cell growth and survival. Many of the “client proteins” of Hsp90 – such
as AKT, ALK, BCR-ABL, BRAF, EGFR, FLT3, HER2, HIF-1alpha, KIT, MET, PDGFRA,
and VEGFR – are the targets of clinically validated cancer drugs. In
preclinical studies, inhibiting Hsp90 causes the degradation of multiple
client proteins and leads to cancer cell death.

About the GALAXY Trials

The GALAXY (Ganetespib Assessment in Lung cAncer with docetaXel) program
consists of two randomized trials comparing the combination of ganetespib and
docetaxel versus docetaxel alone in patients with Stage IIIB/IV NSCLC who have
received one prior systemic therapy: a 300-patient Phase 2b/3 trial (GALAXY-1)
to determine the patient population most likely to derive benefit from
ganetespib, and a 500-patient confirmatory Phase 3 trial (GALAXY-2). More
information about the GALAXY trials can be found at www.clinicaltrials.gov
(NCT01348126 and NCT01798485).

About Synta Pharmaceuticals

Synta Pharmaceuticals Corp. is a biopharmaceutical company focused on
discovering, developing, and commercializing small molecule drugs to extend
and enhance the lives of patients with severe medical conditions, including
cancer and chronic inflammatory diseases. Synta has a unique chemical compound
library, an integrated discovery engine, and a diverse pipeline of clinical-
and preclinical-stage drug candidates with distinct mechanisms of action and
novel chemical structures. All Synta drug candidates were invented by Synta
scientists using our compound library and discovery capabilities. For more
information, please visit www.syntapharma.com.

Safe Harbor Statement

This media release may contain forward-looking statements about Synta
Pharmaceuticals Corp. Such forward-looking statements can be identified by the
use of forward-looking terminology such as "will", "would", "should",
"expects", "anticipates", "intends", "plans", "believes", "may", "estimates",
"predicts", "projects", or similar expressions intended to identify
forward-looking statements. Such statements reflect our current views with
respect to future events and are based on assumptions and subject to risks and
uncertainties that could cause actual results to differ materially from those
expressed or implied by such forward-looking statements, including those
described in "Risk Factors" of our Form 10-K for the year ended December 31,
2012 as filed with the Securities and Exchange Commission. Synta undertakes no
obligation to publicly update forward-looking statements, whether because of
new information, future events or otherwise, except as required by law.

Contact:

Investor Relations Contact:
Synta Pharmaceuticals Corp.
George Farmer, 781-541-7213
gfarmer@syntapharma.com
 
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