EntreMed Announces Changes to Board of Directors and CEO Appointment
ROCKVILLE, Md., April 5, 2013
ROCKVILLE, Md., April 5, 2013 /PRNewswire/ --EntreMed, Inc. (Nasdaq: ENMD), a
clinical-stage pharmaceutical company developing therapeutics for the
treatment of cancer, announced today that its Board of Directors has appointed
two new individuals as directors. Joining the Board are James Huang and Y.
Alexander Wu, Ph.D.
(Logo: http://photos.prnewswire.com/prnh/20010620/ENMDLOGO )
James Huang is Managing Partner of Kleiner Perkins Caufield Byers China and
General Partner of KPCB China Fund II, LP, which invested in EntreMed's
previously announced registered direct financing that closed in March 2013.
Prior to Kleiner Perkins, Mr. Huang was Managing Partner at Vivo Ventures
LLC, a venture capital firm specializing in life science investments. Mr.
Huang has over 20 years of experience in the pharmaceutical and
biopharmaceutical industry. During this time, he has held senior roles in
business development, sales, marketing and R&D with Anesiva, Inc., Tularik
Inc., GlaxoSmithKline LLC, Bristol-Meyers Squibb and ALZA Corp. Mr. Huang
received a B.S. degree in chemical engineering from the University of
California, Berkley and a M.B.A. from the Stanford Graduate School of
Y. Alexander Wu, Ph.D. is co-founder and CEO of Crown Bioscience, Inc., a drug
discovery and preclinical research organization in the oncology sector with
over 300 employees. Before co-founding Crown Bioscience, Alex was Chief
Business Officer of Starvax International Inc., a biopharmaceutical R&D
company focusing on the development of novel therapeutic drugs for the
treatment of infectious disease and cancer. Prior to Starvax, he was the Head
of Asian Operations with Burrill & Company, a life science venture capital and
merchant bank. Dr. Wu also co-founded and was Chief Operating Officer of
Unimicro Technologies, a life science instrumentation company. He started his
career with Hoffmann-La Roche, where he was Manager of Business Development
and Strategic Planning. Dr. Wu obtained his B.S. in biochemistry from Fudan
University, China, a M.S. in Biochemistry from the University of Illinois, and
a Ph.D. in molecular cell biology and MBA from the University of California,
Wei-Wu He, Ph.D., EntreMed's Executive Chairman of the Board, commented on the
appointments, "We are excited about James and Alex joining our Board of
Directors and look forward to their guidance and contribution as we continue
to execute on our global clinical development strategy. James' vast
experience with portfolio companies at Kleiner and extensive business
development experience in the biopharmaceutical industry in both the U.S. and
China will support EntreMed's expanding presence in China and overall global
presence in the marketplace. Alex's 17 plus years of experience in the
biopharmaceutical industry and research in the oncology and small molecule
areas, coupled with his practical experience as a senior executive,
complements the background and skills of the Board and will serve the Company
and our shareholders well at this important juncture in our development and
EntreMed also announced that Mark C. M. Randall has resigned from its Board of
Directors. Dr. He commented, "We would like to recognize Mark's many years of
service and contributions. As a member of our governing body since the
Company's beginning years, Mark has served as a director and at various times
as a member of every committee of the Board. We sincerely wish Mark all the
best in the future and thank him very much for his service to our Company."
EntreMed further announced that Ken K. Ren, Ph.D. has been appointed Chief
Executive Officer, after having completed his one-year term as interim CEO.
Dr. He stated, "Over the past year, Ken has been instrumental in developing
and executing the Company's strategy and has demonstrated executive leadership
and navigated development of our ENMD-2076 program to create value for our
shareholders. We are thrilled that Ken will continue to lead the Company into
a promising future."
EntreMed, Inc. is a clinical-stage pharmaceutical company employing a drug
development strategy primarily in the United States and China to develop
targeted therapeutics for the global market. Its lead compound, ENMD-2076, a
selective angiogenic kinase inhibitor, has completed several Phase 1 studies
in solid tumors, multiple myeloma, and leukemia, and is currently completing a
multi-center Phase 2 study in ovarian cancer. EntreMed, Inc. recently
announced the initiation of a Phase 2 study of ENMD-2076 in triple-negative
breast cancer and the initiation of a Phase 2 study of ENMD-2076 in
advanced/metastatic soft tissue sarcoma. Additional information about
EntreMed is available on the Company's web site at www.entremed.com and in
various filings with the Securities and Exchange Commission (the SEC).
ENMD-2076 is an orally-active, Aurora A/angiogenic kinase inhibitor with a
unique kinase selectivity profile and multiple mechanisms of action.
ENMD-2076 has been shown to inhibit a distinct profile of angiogenic tyrosine
kinase targets in addition to the Aurora A kinase. Aurora kinases are key
regulators of mitosis (cell division), and are often over-expressed in human
cancers. ENMD-2076 also targets the VEGFR, Flt-3 and FGFR3 kinases which have
been shown to play important roles in the pathology of several cancers.
ENMD-2076 has shown promising activity in Phase 1 clinical trials in solid
tumor cancers, leukemia, and multiple myeloma. ENMD-2076 is currently
completing a Phase 2 trial for ovarian cancer. EntreMed, Inc. recently
initiated a dual-institutional Phase 2 study of ENMD-2076 in triple-negative
Forward Looking Statements
This release contains forward-looking statements within the meaning of the
Private Securities Litigation Reform Act with respect to the outlook for
expectations for future financial or business performance, strategies,
expectations and goals. Forward-looking statements are subject to numerous
assumptions, risks and uncertainties, which change over time. Forward-looking
statements speak only as of the date they are made, and no duty to update
forward-looking statements is assumed.
Actual results could differ materially from those currently anticipated due to
a number of factors, including: the risk that we may be unable to continue as
a going concern as a result of our inability to raise sufficient capital for
our operational needs; the possibility that we may be delisted from trading on
the Nasdaq Capital Market; the volatility of our common stock; the difficulty
of executing our business strategy in China; our inability to enter into
strategic partnerships for the development, commercialization, manufacturing
and distribution of our proposed product candidate; risks relating to the need
for additional capital and the uncertainty of securing additional funding on
favorable terms; declines in actual sales of Thalomid® resulting in reduced
royalty payments; risks associated with our product candidates; any
early-stage products under development; results in preclinical models are not
necessarily indicative of clinical results; uncertainties relating to
preclinical and clinical trials, including delays to the commencement of such
trials; the lack of success in the clinical development of any of our
products; dependence on third parties; and risks relating to the
commercialization, if any, of our proposed products (such as marketing,
safety, regulatory, patent, product liability, supply, competition and other
risks). Such factors, among others, could have a material adverse effect upon
our business, results of operations and financial condition. We caution
readers not to place undue reliance on any forward-looking statements, which
only speak as of the date made. Additional information about the factors and
risks that could affect our business, financial condition and results of
operations, are contained in our filings with the U.S. Securities and Exchange
Commission ("SEC"), which are available at www.sec.gov.
SOURCE EntreMed, Inc.
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