SHIRE PLC: Director/PDMR Shareholding

Director/PDMR Share Dealings 
April 2, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG), (the "Company") announces
that it was notified on March 28, 2013 that on the same day the Ordinary Shares
("Shares") and American Depository Shares ("ADSs") of the Company, as set out
below, had been awarded under the Shire Executive Annual Incentive Plan
("EAIP") to Persons Discharging Managerial Responsibility ("PDMRs"). The Shares
and ADSs were acquired on March 28, 2013 at prices of £19.94 per Share and
$90.00 per ADS. 


                                           Type of       Number of     
                                          Security                     
                                                        Shares/ADSs    


                                                                   
Angus Russell (Chief Executive Officer)     ADSs             3,123      
                                                                   
Graham Hetherington (Chief Financial       Shares            4,504     
Officer)                                                                
                                                                   
Sylvie Gregoire                             ADSs             1,262      
                                                                   
Jeffrey Jonas                               ADSs               932      
                                                                   
Tatjana May                                Shares            2,702      
The awards will normally be released to participants after a period of three
years. One ADS is equal to three Shares. 
In addition, the Company was notified on April 2, 2013 of the release of the
following ADSs and Shares awarded in 2010 under the EAIP. 


                                       Type of    Number of    Number of Shares
                                      Security   Shares/ADSs    /ADSs sold to  
                                                   released      satisfy tax   
                                                                 liabilities   


                                                                           
Angus Russell (Chief Executive          ADSs             7,421            6,176
Officer)                                                                        
                                                                           
Graham Hetherington (Chief Financial   Shares           12,569            6,552
Officer)                                                                        
                                                                           
Tatjana May                            Shares            7,515            3,918 
                                                                            
On April 1 and April 2, 2013, sufficient ADSs and Shares were sold
respectively, to satisfy tax liabilities as set out above. The ADSs and Shares
were sold at prices of $90.9568 per ADS and £19.94 per Share. 
The above transactions in Shares and ADSs took place on the London Stock
Exchange and NASDAQ respectively. 
This notification relates to disclosures made in accordance with 3.1.4(R)(1)(a)
of the Disclosure and Transparency Rules. 
Tony Guthrie
Deputy Company Secretary 
For further information please contact: 
Investor Relations                                                              
                                                                           
Eric Rojas                              erojas@shire.com     +1 781 482 0999    
                                                                           
Sarah Elton-Farr                        seltonfarr@shire.com +44 1256 894157    
Notes to editors 
Shire enables people with life-altering conditions to lead better lives. 
Through our deep understanding of patients' needs, we develop and provide
healthcare in the areas of: 
* Behavioral Health and Gastro Intestinal conditions 


      * Rare Diseases
      * Regenerative Medicine
    as well as other symptomatic conditions treated by specialist physicians.

We aspire to imagine and lead the future of healthcare, creating value for
patients, physicians, policymakers, payors and our shareholders.
                                                                              

Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX

Press Release                                     


                                              
www.shire.com 
-0- Apr/02/2013 15:05 GMT
 
 
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