SHIRE PLC: Director/PDMR Shareholding

Director/PDMR Share Dealings 
April 2, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG), (the "Company") announces
that it was notified on March 28, 2013 that on the same day the Ordinary Shares
("Shares") and American Depository Shares ("ADSs") of the Company, as set out
below, had been awarded under the Shire Executive Annual Incentive Plan
("EAIP") to Persons Discharging Managerial Responsibility ("PDMRs"). The Shares
and ADSs were acquired on March 28, 2013 at prices of £19.94 per Share and
$90.00 per ADS. 

                                           Type of       Number of     

Angus Russell (Chief Executive Officer)     ADSs             3,123      
Graham Hetherington (Chief Financial       Shares            4,504     
Sylvie Gregoire                             ADSs             1,262      
Jeffrey Jonas                               ADSs               932      
Tatjana May                                Shares            2,702      
The awards will normally be released to participants after a period of three
years. One ADS is equal to three Shares. 
In addition, the Company was notified on April 2, 2013 of the release of the
following ADSs and Shares awarded in 2010 under the EAIP. 

                                       Type of    Number of    Number of Shares
                                      Security   Shares/ADSs    /ADSs sold to  
                                                   released      satisfy tax   

Angus Russell (Chief Executive          ADSs             7,421            6,176
Graham Hetherington (Chief Financial   Shares           12,569            6,552
Tatjana May                            Shares            7,515            3,918 
On April 1 and April 2, 2013, sufficient ADSs and Shares were sold
respectively, to satisfy tax liabilities as set out above. The ADSs and Shares
were sold at prices of $90.9568 per ADS and £19.94 per Share. 
The above transactions in Shares and ADSs took place on the London Stock
Exchange and NASDAQ respectively. 
This notification relates to disclosures made in accordance with 3.1.4(R)(1)(a)
of the Disclosure and Transparency Rules. 
Tony Guthrie
Deputy Company Secretary 
For further information please contact: 
Investor Relations                                                              
Eric Rojas                         +1 781 482 0999    
Sarah Elton-Farr               +44 1256 894157    
Notes to editors 
Shire enables people with life-altering conditions to lead better lives. 
Through our deep understanding of patients' needs, we develop and provide
healthcare in the areas of: 
* Behavioral Health and Gastro Intestinal conditions 

      * Rare Diseases
      * Regenerative Medicine
    as well as other symptomatic conditions treated by specialist physicians.

We aspire to imagine and lead the future of healthcare, creating value for
patients, physicians, policymakers, payors and our shareholders.

Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX

Press Release                                     

-0- Apr/02/2013 15:05 GMT
Press spacebar to pause and continue. Press esc to stop.