SHIRE PLC: Director/PDMR Shareholding

Director/PDMR Share Dealings 
April 2, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG), (the "Company") announces
that on March 28, 2013 Ordinary Shares ("Shares") and American Depository
Shares ("ADSs") of the Company, as set out below, had been acquired for the
Non-Executive Directors, being the part of their total fees that are paid in
shares for the period of service from January 1 to March 31, 2013. 
                    Type of Security (1)     Number of Shares/ADSs  
William Burns                  Shares                           255     
Dr. Steven Gillis               ADSs                             80     
Dr. David Ginsburg              ADSs                             73     
David Kappler                  Shares                           302     
Susan Kilsby                    ADSs                             75     
Anne Minto                     Shares                           266     
David Stout                     ADSs                             81     
(1) One ADS is equal to three Shares 
The Shares and ADSs were acquired on the London Stock Exchange and NASDAQ
respectively, at prices of £19.90 per Share and $90.00 per ADS. 
This notification relates to disclosures made in accordance with 3.1.4(R)(1)(a)
of the Disclosure and Transparency Rules. 
Tony Guthrie
Deputy Company Secretary 
For further information please contact: 
Investor Relations                                                              
Eric Rojas                         +1 781 482 0999    
Sarah Elton-Farr               +44 1256 894157    
Notes to editors 
Shire enables people with life-altering conditions to lead better lives. 
Through our deep understanding of patients' needs, we develop and provide
healthcare in the areas of: 
* Behavioral Health and Gastro Intestinal conditions 

      * Rare Diseases
      * Regenerative Medicine
    as well as other symptomatic conditions treated by specialist physicians.

We aspire to imagine and lead the future of healthcare, creating value for
patients, physicians, policymakers, payors and our shareholders.

Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX

Press Release                                     

-0- Apr/02/2013 12:47 GMT
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