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SHIRE PLC: Director/PDMR Shareholding

Director/PDMR Share Dealings

April 2, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG), (the "Company") announces that on March 28, 2013 Ordinary Shares ("Shares") and American Depository Shares ("ADSs") of the Company, as set out below, had been acquired for the Non-Executive Directors, being the part of their total fees that are paid in shares for the period of service from January 1 to March 31, 2013.

Type of Security (1) Number of Shares/ADSs

William Burns Shares 255

Dr. Steven Gillis ADSs 80

Dr. David Ginsburg ADSs 73

David Kappler Shares 302

Susan Kilsby ADSs 75

Anne Minto Shares 266

David Stout ADSs 81

(1) One ADS is equal to three Shares

The Shares and ADSs were acquired on the London Stock Exchange and NASDAQ respectively, at prices of £19.90 per Share and $90.00 per ADS.

This notification relates to disclosures made in accordance with 3.1.4(R)(1)(a) of the Disclosure and Transparency Rules.

Tony Guthrie Deputy Company Secretary

For further information please contact:

Investor Relations

Eric Rojas +1 781 482 0999

Sarah Elton-Farr +44 1256 894157

Notes to editors

Shire enables people with life-altering conditions to lead better lives.

Through our deep understanding of patients' needs, we develop and provide healthcare in the areas of:

* Behavioral Health and Gastro Intestinal conditions

      * Rare Diseases
      * Regenerative Medicine
    as well as other symptomatic conditions treated by specialist physicians.

We aspire to imagine and lead the future of healthcare, creating value for
patients, physicians, policymakers, payors and our shareholders.

Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX

Press Release                             

-0- Apr/02/2013 12:47 GMT

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