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KOHJIN Life Sciences and Kyoto Prefectural University presented the findings on the Identification of Glutathione in Human Blood



  KOHJIN Life Sciences and Kyoto Prefectural University presented the findings
  on the Identification of Glutathione in Human Blood after Oral
  Administration at the ISNFF Academic Meeting.

 The first report of its kind that identified the food derived Glutathione in
                  the human blood after oral administration

Business Wire

TOKYO -- March 29, 2013

KOHJIN Life Sciences (KJLS), a subsidiary of Mitsubishi Corporation Life
Sciences Ltd, and Dr. Kenji Sato of Kyoto Prefectural University (KPU)
presented the findings on the identification and determination of the change
of food derived L-Glutathione in human blood after oral administration at the
annual academic meeting of ISNFF.

L-Glutathione (GSH) manufactured by KJLS is produced by fermentation with
Torula Yeast, FDA GRAS Notice #GRN000293, KOHJIN Life Sciences Co.,Ltd.

GSH has a long history as a natural supplement to improve liver function and
skin whitening. However, no significant increase of GSH has been detected in
human blood after oral ingestion of GSH. As a result, the benefits of GSH
supplementation have been in question for many years.

However, KJLS established a new method for detection of Glutathione based on
the hypothesis that GSH is might be transported as conjugates with protein
(Glutathione Binding Protein, GBP) in the blood. Therefore, all past studies
could not identify the change of glutathione levels in human blood. In KJLS’s
study, samples were extracted with TCA and 2-mercapthoethanol to liberate GSH
from the conjugate. The liberated GSH were treated with AccQ to improve
resolution by RP-HPLC. In the presence of 2-mercaptoethaol, GSH yielded
AQC-GSH-2-mercaptoethanol.H^+ ions by ESI-MS analysis. In the absence of
2-mercaptoethaol, GSH yielded H^+.AQC-GSSG-AQC.H^+ ions. By monitoring these
ions, the present study first demonstrates the increase of GSH bond to protein
in human plasma after ingestion of GSH.

This study is the first report of its kind that identified the Glutathione in
human blood after oral administration. KJLS attributes the success of this
result to its natural production method based on fermentation with Torula
Yeast. KOHJIN Glutathione has a FDA Notified GRAS and is suitable for food
ingredient. KJLS and KPU are conducting more studies about the mechanism of
GSH absorption pathway in the human body, and KJLS and KPU will publish these
studies in near future.

About KOHJIN Life Sciences

KOHJIN Life Sciences supplies products that enrich people's lifestyles as it
seek to establish itself as an asset to society. KJLS also continue to expand
its corporate activities with the awareness that environmental conservation is
one element of corporate social responsibility.

About Kyoto Prefectural University

Kyoto Prefectural University ushers in its 118th academic year in 2013. Its
precursors include Kyoto Prefectural Agricultural School, which was founded in
1895 and later re-organized as Kyoto Prefectural College of Agriculture and
Forestry, and the Kyoto Prefectural Woman’s Vocational School founded in 1927.
Under the school education act of 1949, a new university was established based
on the integration of these institutions. The Kyoto Prefectural Public
University Corporation was established April 1, 2008, and the university now
consists of three faculties: the Faculty of Letters, the Faculty of Public
Policy and the Faculty of Life and Environmental Sciences; and three graduate
schools: the Graduate School of Letters, the Graduate School of Public Policy
and the Graduate School of Life and Environmental Sciences.

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http://www.businesswire.com/multimedia/home/20130329005136/en/

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Available:http://www.businesswire.com/cgi-bin/mmg.cgi?eid=50600213&lang=en

Contact:

KOHJIN Life Sciences Co.,Ltd. (JAPAN)
Yusuke Sauchi, +81-3-3539-1692
yusuke.sauchi@kohjinls.com
Mitsubishi International Food Ingredients, Inc. (CANADA)
Robert Price, 604-654-8137
rprice@mitsubishiingredients.com
Mitsubishi International Food Ingredients, Inc. (USA)
Gregory Shinkawa, 310-291-9988
gshinkawa@mitsubishiingredients.com
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