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SHIRE PLC: Transaction in Own Shares

Transaction in Own Shares 
March 20, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company"), announces
that in accordance with the authority granted by shareholders at the Company's
Annual General Meeting on April 24, 2012 it purchased 38,000 of its ordinary
shares of 5 pence each ("Ordinary Shares") on March 19, 2013 through both
direct purchases of Ordinary Shares and through the purchase of Ordinary Shares
underlying ADRs. The highest and lowest price paid for the directly acquired
Ordinary Shares was 2032.00 pence per share and 2013.00 pence per share
respectively and for those Ordinary Shares acquired through the purchase of
ADRs was 3069.00 cents per share and 3053.33 cents per share respectively. 
The purchased shares will be held as treasury shares. Following the above
purchase, the Company holds 5,568,888 Ordinary Shares as treasury shares and
has 557,236,153 Ordinary Shares in issue (excluding treasury shares). 
The purchases were made by an independent third party which makes its trading
decisions independently of, and uninfluenced by the Company. The independence
of the third party enables the Company to continue to purchase Ordinary Shares
(including Ordinary Shares underlying ADRs) during close periods and other
prohibited periods, should they arise. The third party has been appointed by
the Company to make purchases to December 31, 2013. 
For further information please contact: 
Investor Relations                                                              
                                                                           
Eric Rojas                              erojas@shire.com     +1 781 482 0999    
                                                                           
Sarah Elton-Farr                        seltonfarr@shire.com +44 1256 894157    
NOTES TO EDITORS 
Shire enables people with life-altering conditions to lead better lives. 
Through our deep understanding of patients' needs, we develop and provide
healthcare in the areas of: 
* Behavioral Health and Gastro Intestinal conditions 


      * Rare Diseases
      * Regenerative Medicine
    as well as other symptomatic conditions treated by specialist physicians.

We aspire to imagine and lead the future of healthcare, creating value for
patients, physicians, policymakers, payors and our shareholders.
                                                                              

Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX


                                                                          
Press Release                                      
                                              
www.shire.com 
-0- Mar/20/2013 07:00 GMT