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MAKO Surgical Corp. Showcases Pioneering MAKOplasty(R) Treatment Options for Total Hip Replacement and Partial Knee Resurfacing

MAKO Surgical Corp. Showcases Pioneering MAKOplasty(R) Treatment Options for
Total Hip Replacement and Partial Knee Resurfacing Surgeries at AAOS 2013
Annual Meeting

Innovative Procedure Uses Robotic Arm Tactile Technology to Assist Surgeons in
Achieving a New Level of Accuracy

CHICAGO, March 18, 2013 (GLOBE NEWSWIRE) -- MAKO Surgical Corp. (Nasdaq:MAKO),
the leader in robotic arm assisted partial knee and total hip arthroplasty
worldwide, today announced that it will showcase its MAKOplasty^® Total Hip
Arthroplasty (THA) and Partial Knee Resurfacing applications at the American
Academy of Orthopaedic Surgeons 2013 Annual Meeting (AAOS), March 20-23 at
McCormick Place in Chicago. During the meeting, orthopedic surgeons will
deliver presentations and provide hands-on demonstrations in MAKO's booth
#212.

MAKOplasty THA is the company's latest application for its RIO^® Robotic Arm
Interactive Orthopedic System, which will be highlighted by the company during
the meeting. The RIO system overcomes limitations of conventional arthroplasty
surgeries by providing auditory, visual and tactile guidance that, when
integrated with the touch and feel of the surgeon's skilled hand, provides
consistently reproducible precision in total hip and partial knee surgeries.
MAKO's robotic arm assisted THA may result in a reduction in complications
associated with conventional hip replacement surgery.

"With total hip replacement using MAKO robotic-arm assistance, I am a better
surgeon because I perform 95 percent of my operations with the implants always
in the correct position," said Lawrence Dorr, M.D., clinical professor of
orthopedics at Keck School of Medicine at University of Southern California in
Los Angeles. "This is better than the Harvard data, which showed 47 percent of
the implants in the correct position^1. Even in my own practice, the MAKO
robotic-arm assistance provides me with greater precision compared to when I
perform the hip replacement using my experience only. Every patient who comes
to me expects me to give him or her a precise operation. My consistent results
allow me to fulfill the trust the patient puts in me," said Dr. Dorr.

"Knowing I have an accurate hip reconstruction gives me confidence I have
minimized the risks for impingement and its consequent complications of
dislocation, pain and accelerated wear. I also believe I have optimized the
chance for durability of the hip replacement of 30 years," continued Dr. Dorr.

Hip replacement with MAKO's robotic-arm assistance builds upon the proven
benefits of MAKOplasty Partial Knee Resurfacing, developed as an advanced
treatment option designed to relieve pain for adults living with early to
mid-stage osteoarthritis that has not yet spread to all three compartments of
the knee. The use of the RIO system in MAKOplasty partial knee resurfacing
leads to implant component placement that is two to three times more accurate
than manual techniques^2. Studies also show that patients with bicompartmental
MAKOplasty have improved function over those with total knee replacement
surgery, and that these MAKOplasty patients demonstrate better post-operative
range of motion and quadriceps strength compared to total knee arthroplasty^3.

"The MAKOplasty procedure with the RIO system for THA and partial knee
resurfacing not only improves accuracy and reproducibility in surgery, it
improves my patients' recovery," said Robert C. Marchand, M.D., a partner at
South County Orthopedics in Wakefield, R.I., and one of the presenters in
MAKO's booth during the AAOS 2013 Annual Meeting. "With partial knee
resurfacing for example, I am able to use the RIO system to create an
anatomical model of the patient's knee and develop a patient specific plan for
optimal implant positioning based on the patient's individual anatomy. The RIO
provides feedback and guidance, thereby preventing me from removing bone form
outside the specified plan, and it allows for accurate implant placement. Our
patients recover more quickly compared to conventional techniques and their
post-operative range of motion is improved as well."

Additional studies describing the clinical success using MAKO's RIO system and
its RESTORIS^® family of implants when performing MAKOplasty procedures are
beginning to appear in peer-reviewed journals, and a body of growing clinical
data continues to be presented at academic meetings worldwide. In a recent
oral presentation of a multi-center trial, the authors presented key results
regarding the accuracy of robotic arm cup placement in total hip procedures,
and reported 87 percent were positioned in an acceptable range. This compares
favorably to data from a recently published Massachusetts General Hospital
(MGH) study, which evaluated 1,823 hips receiving manual total hip
arthroplasty, which reported 47 percent of cups were placed in an acceptable
rage. Mal-positioning of acetabular cups in conventional hip replacement
surgery may lead to impingement and implant wear that can cause dislocation^4.
Nearly 300,000 primary hip replacement surgeries are performed annually in the
United States using conventional technique.

Another multi-center study of MAKOplasty partial knee cases using RESTORIS MCK
onlay medial unicompartmental implants, found very low two year post-operative
revision rates of 0.4 percent, compared to two year revision rates reported at
4.0 percent and 4.4 percent respectively in the Swedish and Australian
registries^5.

As of December 31, 2012, approximately 23,000 MAKOplasty procedures have been
performed worldwide.

About MAKO Surgical Corp.

MAKO Surgical Corp.is a medical device company that markets its RIO^®
Robotic-Arm Interactive Orthopedic system, with specific applications for
partial knee resurfacing and total hip replacement, and proprietary RESTORIS^®
Family of Implants for orthopedic procedures called MAKOplasty^®. The RIO is a
surgeon-interactive tactile surgical platform that incorporates a robotic arm
and patient-specific visualization technology, which enables accurate,
consistently reproducible bone resection for accurate insertion and alignment
of RESTORIS knee and hip implants. The MAKOplasty solution incorporates
technologies enabled by an intellectual property portfolio including more than
300 U.S. and foreign, owned and licensed, patents and patent applications.
Additional information can be found at www.makosurgical.com.

Forward-Looking Statements

This press release contains forward-looking statements regarding, among other
things, statements related to expectations, goals, plans, objectives and
future events. MAKO intends such forward-looking statements to be covered by
the safe harbor provisions for forward-looking statements contained in Section
21E of the Securities Exchange Act of 1934 and the Private Securities Reform
Act of 1995. In some cases, forward-looking statements can be identified by
the following words: "may," "will," "could," "would," "should," "expect,"
"intend," "plan," "anticipate," "believe," "estimate," "predict," "project,"
"potential," "continue," "ongoing," or the negative of these terms or other
comparable terminology, although not all forward-looking statements contain
these words. These statements are based on the current estimates and
assumptions of our management as of the date of this press release and are
subject to risks, uncertainties, changes in circumstances, assumptions and
other factors that may cause actual results to differ materially from those
indicated by forward-looking statements, many of which are beyond MAKO's
ability to control or predict. Such factors, among others, may have a material
adverse effect on MAKO's business, financial condition and results of
operations and may include the potentially significant impact of a continued
economic downturn or delayed economic recovery on the ability of MAKO's
customers to secure adequate funding, including access to credit, for the
purchase of MAKO's products or cause MAKO's customers to delay a purchasing
decision, changes in general economic conditions and credit conditions,
changes in the availability of capital and financing sources for our company
and our customers, unanticipated changes in the timing of the sales cycle for
MAKO's products or the vetting process undertaken by prospective customers,
changes in competitive conditions and prices in MAKO's markets, changes in the
relationship between supply of and demand for our products, fluctuations in
costs and availability of raw materials and labor, changes in other
significant operating expenses, slowdowns, delays, or inefficiencies in MAKO's
product research and development cycles, unanticipated issues relating to
intended product launches, decreases in sales of MAKO's principal product
lines, decreases in utilization of MAKO's principal product lines or in
procedure volume, increases in expenditures related to increased or changing
governmental regulation or taxation of MAKO's business, both nationally and
internationally, unanticipated issues in complying with domestic or foreign
regulatory requirements related to MAKO's current products, including
initiating and communicating product actions or product recalls and meeting
Medical Device Reporting requirements and other required reporting to the
United States Food and Drug Administration, or securing regulatory clearance
or approvals for new products or upgrades or changes to MAKO's current
products, developments adversely affecting our potential sales activities
outside the United States, increases in cost containment efforts by group
purchasing organizations, the impact of the United States healthcare reform
legislation enacted in March 2010 on hospital spending, reimbursement,
unanticipated changes in reimbursement to our customers for our products, and
the taxing of medical device companies, any unanticipated impact arising out
of the securities class action or any other litigation, inquiry, or
investigation brought against MAKO, loss of key management and other personnel
or inability to attract such management and other personnel, increases in
costs of retaining a direct sales force and building a distributor network,
unanticipated issues related to, or unanticipated changes in or difficulties
associated with, the recruitment of agents and distributors of our products,
and unanticipated intellectual property expenditures required to develop,
market, and defend MAKO's products. These and other risks are described in
greater detail under Item 1A, "Risk Factors," in MAKO's periodic filings with
the Securities and Exchange Commission, including MAKO's annual report on Form
10-K for the year ended December 31, 2012 filed on February 28, 2013. Given
these uncertainties, undue reliance should not be placed on these
forward-looking statements. MAKO does not undertake any obligation to release
any revisions to these forward-looking statements publicly to reflect events
or circumstances after the date of this press release or to reflect the
occurrence of unanticipated events.

"MAKOplasty®," "RESTORIS®," "RIO®," as well as the "MAKO" logo, whether
standing alone or in connection with the words "MAKO Surgical Corp." are
trademarks of MAKO Surgical Corp.

^1 Callanan MC, Jarrett B, Bragdon CR, Zurakowski D, Rubash HE, Freiberg AA,
Malchau H. The John Charley Award: Risk factors for cup malpositioning:
Quality improvement through a joint registry at a tertiary hospital. Clin
Orthop Relat Res. 2011;469(2):319-329.

^2 Dunbar NJ, Pearle AD, Kenoff D, Conditt M, Banks S. Is UKA more accurate
with robotic assistance? 56^th Orthopedic Research Society Annual Meeting,
March 6-9 2010. New Orleans, LA.

^3 Kreuzer S, Conditt M, Jones J, Dalal S, Pourmoghaddam A Functional recovery
after bicompartmental arthroplasty, navigated TKA, and traditional TKA. 25^th
Annual Congress of ISTA, October 3-6, 2012, Sydney, Australia.

^4 Clinical Orthopaedics and Related Research. 2011:469(2)319-329.

^5 Roche MW, Coon T, Pearle AD, Dounchis J. Two year survivorship of
robotically guided medial MCK onlay. 25th Annual Congress of ISTA, October
3-6, 2012, Sydney, Australia.

CONTACT: Media Contacts:
         Amy Cook
         925.552.7893
         amycook@amcpublicrelations.com
        
         Sue Siebert
         954.628.0804
         ssiebert@makosurgical.com
 
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