SHIRE PLC: Director/PDMR Share Dealings

Director/PDMR Share Dealings

March 4, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG), (the `Company') announces that on February 28, 2013 the following Persons Discharging Managerial Responsibility (`PDMRs') were granted awards under the Shire Portfolio Share Plan (`PSP').

Stock Appreciation Right Awards (`SAR Awards') under Part A of the PSP

SAR Awards will normally vest after three years, subject to any performance conditions being satisfied. No consideration is payable for these awards.

Type of Security(1) No of Ordinary Exercise price

Shares/ADSs

Flemming Ornskov(2) ADSs 45,601 $95.04

Graham Hetherington(2) Ordinary Shares 66,708 £20.88

Jeffrey Jonas ADSs 6,291 $95.04

Tatjana May Ordinary Shares 22,489 £20.88

Performance Share Awards (`PSA Awards') under Part B of the PSP

PSA Awards will normally vest after three years, subject to any performance conditions being satisfied. No consideration is payable for these awards.

                            Type of Security(1)   No of Ordinary 
                                                  Shares/ADSs   

Flemming Ornskov(2) ADSs 34,201

Graham Hetherington(2) Ordinary Shares 48,919

Jeffrey Jonas ADSs 4,529

Tatjana May Ordinary Shares 16,192

(1). One ADS is equal to three Shire plc ordinary shares of 5 pence each.

(2). Vesting of awards granted to Executive Directors is subject to performance conditions.

Release of PSA Awards

The Company also announces that on March 1, 2013 the following ordinary shares and ADSs were released in connection with PSA Awards granted on 1 March 2010 under Part B of the PSP. The Company was notified today that sufficient ordinary shares and ADSs were sold on March 1, 2013 to satisfy the relevant personal tax liabilities of each PDMR.

                           Number of ADSs     Number of ADSs 
                             released(4)          sold(5)     

Angus Russell(3) 75,033 30,342

Sylvie Gregoire 15,220 5,339

Jeffrey Jonas 2,115 633

                              Number of         Number of    
                           Ordinary Shares   Ordinary Shares 
                              released(4)        sold(6)      

Graham Hetherington(3) 100,314 52,594

Tatjana May 28,410 14,896

(3). The PSA Awards granted in 2010 to Angus Russell and Graham Hetherington were subject to performance conditions measured over the performance period 2010 to 2012. Based on the performance conditions, 100% of the PSA Awards vested.

(4). In accordance with the rules of the PSP, the vested PSA awards have been increased to reflect the dividends paid by the Company in the period from the grant date to the vesting date.

(5). ADSs were sold on the NASDAQ at an average sale price of $94.28028 each.

(6). Ordinary shares were sold on the London Stock Exchange at an average sale price of £20.76842 each.

This notification is made to satisfy the Company's obligations under 3.1.4(R) (1)(a) of the Disclosure and Transparency Rules.

Tony Guthrie Deputy Company Secretary

For further information please contact:

Investor Relations

Eric Rojas erojas@shire.com +1 781 482 0999

Sarah Elton-Farr seltonfarr@shire.com +44 1256 894157

Notes to editors

Shire enables people with life-altering conditions to lead better lives.

Through our deep understanding of patients' needs, we develop and provide healthcare in the areas of:

* Behavioral Health and Gastro Intestinal conditions

      * Rare Diseases
      * Regenerative Medicine
    as well as other symptomatic conditions treated by specialist physicians.

We aspire to imagine and lead the future of healthcare, creating value for
patients, physicians, policymakers, payors and our shareholders.
                                                                              

Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX

Press Release                                     

www.shire.com

END

-0- Mar/04/2013 16:06 GMT