SHIRE PLC: PDMR Share Dealings

PDMR Share Dealings 
March 1, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG), (the "Company") announces
the following dealings by Persons Discharging Managerial Responsibility 
n American Depository Shares ("ADSs").  One ADS is equal to three Shire plc 
rdinary shares of 5 pence each. 
Release of Performance Share Awards ("PSA Awards") 
In accordance with the rules of the Portfolio Share Plan ("PSP"), the following  
ADSs were released on February 28, 2013 in connection with PSA Awards granted 
under Part B of the PSP.  The Company was notified today that on February 28,
2013 sufficient ADSs were sold on the NASDAQ at an average sale price of
$94.1859 to satisfy the related personal tax liabilities of each PDMR. 
                           Number of ADSs  Number of 

               Date of grant released 2      ADSs sold

Ann Judge1      28/02/2012         297       91
                28/02/2011         423       149

Jeffrey Jonas1  28/02/2012         386       114 

                28/02/2011         507       152

1     The PSA Awards were granted prior to Ann Judge and Jeffrey Jonas becoming

  PDMRs.  In accordance with the rules of the PSP, such awards vest 
  over a three year period. 
2     In accordance with the rules of the PSP, the vested PSA awards have been 
  to reflect the dividends paid by the Company in the period from the grant 
  to the vesting date. 
This notification relates to disclosures made in accordance with 3.1.4(R)(1)(a) 
of the
Disclosure and Transparency Rules. 
Tony Guthrie
Deputy Company Secretary 
For further information please contact: 
Investor Relations
Eric Rojas                 +1 781 482 0999
Sarah Elton-Farr       +44 1256 894157 
Shire enables people with life-altering conditions to lead better lives. 
Through our deep understanding of patients' needs, we develop and provide
healthcare in the areas of: 
- Behavioral Health and Gastro Intestinal conditions 
- Rare Diseases 
- Regenerative Medicine 
as well as other symptomatic conditions treated by specialist physicians. 
We aspire to imagine and lead the future of healthcare, creating value for
patients, physicians, policymakers, payors and our shareholders. 
-0- Mar/01/2013 16:00 GMT
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