BG Medicine, Inc. Announces Publication of Two Studies Supporting Repeat Galectin-3 Testing in Heart Failure Patients

BG Medicine, Inc. Announces Publication of Two Studies Supporting Repeat
Galectin-3 Testing in Heart Failure Patients

WALTHAM, Mass., Feb. 27, 2013 (GLOBE NEWSWIRE) -- BG Medicine, Inc.
(Nasdaq:BGMD), a diagnostics company focused on the development and
commercialization of novel cardiovascular tests, announced today the
publication of two studies demonstrating the clinical utility of repeated
galectin-3 testing as a tool in the assessment of patients with heart failure.
The studies, which together involved more than 3,300 subjects, demonstrate
that periodic evaluation of galectin-3 levels can help clinicians identify
those at greater risk of unplanned hospital admission and cardiovascular
morbidity and mortality.

The first study, published online ahead of print in the current issue of
Circulation Heart Failure [1], demonstrated that patients who experienced
increases in their galectin-3 levels in excess of 15% over a period of three
to six months had nearly double the risk of subsequent unplanned hospital
admissions and mortality relative to patients who did not experience changes
in their galectin-3 levels over the same time period. This increased risk was
found to be independent of other important risk factors in heart failure,
including cardiac function, renal function, age, and levels of NT-proBNP.

The second study, published online ahead of print in the European Journal of
Heart Failure [2], demonstrated that patients who experienced increases in
galectin-3 levels over a period of four months were at significantly increased
risk of subsequent unplanned hospital admissions for heart failure, first
morbid event, and mortality. The increased risk associated with elevations in
galectin-3 was found to be independent of all other baseline heart failure
risk factors considered. Importantly, this increased risk associated with
galectin-3 elevation was also demonstrated to be independent of, and additive
to, concomitant changes in other important heart failure risk factors,
including cardiac structure, renal function, blood pressure, heart rate,
NT-proBNP levels, and other clinical patient parameters.

"We are very encouraged by these published results, which add to the growing
body of evidence supporting the repeated use of galectin-3 testing as an
ongoing monitoring tool in the management of patients with heart failure,"
said Eric Bouvier, President and CEO of BG Medicine. "We believe these
findings validate our commercial focus on the use of galectin-3 testing to
combat unplanned hospital readmissions, and will help us drive further
clinical adoption of galectin-3 testing as a routine part of heart failure
management."

The BGM Galectin-3® Test is cleared by the FDA as an aid in assessing the
prognosis of patients with chronic heart failure, to be used in conjunction
with clinical evaluation.

About Galectin-3 and Heart Failure

Galectin-3 is a unique carbohydrate-binding lectin, or protein, that binds to
carbohydrates called beta-galactosides. Galectin-3 has been implicated in a
variety of biological processes important in the development and progression
of heart failure, and is believed to be a primary mediator of progressive
cardiac fibrosis (abnormal thickening and stiffening of the heart muscle) and
adverse remodeling (changes in the structure of the heart). Higher levels of
galectin-3 are associated with a more aggressive form of heart failure and 30%
or more of mild to moderate heart failure patients will have elevated levels
of galectin-3. Heart failure affects an estimated 5.7 million Americans, with
approximately 670,000 new cases occurring each year. The direct and indirect
cost of heart failure in the United States for 2011 is estimated to be $34.4
billion [3,4].

About BG Medicine, Inc.

BG Medicine, Inc. (Nasdaq:BGMD) is a diagnostics company focused on the
development and commercialization of novel cardiovascular tests to address
significant unmet medical needs, improve patient outcomes and reduce
healthcare costs. The Company has two products: the BGM Galectin-3^® test for
use in patients with chronic heart failure is available in the United States
and Europe; and the CardioSCORE™ test for the risk prediction of major
cardiovascular events will be launched in Europe in the first half of 2013.
For additional information about BG Medicine, heart failure and galectin-3
testing, please visit www.bg-medicine.com and www.galectin-3.com.

The BG Medicine Inc. logo is available at the following link:
http://www.globenewswire.com/newsroom/prs/?pkgid=10352.

Publication Details:

[1] van der Velde AR, Gullestad L, Ueland T, et al. Prognostic Value of
Changes in Galectin-3 Levels Over Time in Patients with Heart Failure: Data
from CORONA and COACH. Circ Heart Fail. 2013 (Published online February 8,
2013, doi: 10.1161/circheartfailure.112.000129).

[2] Anand IS, Rector TS, Kuskowski M, et al. Baseline and Serial Measurements
of Galectin-3 in Patients with Heart Failure: Relationship to Prognosis and
Effect of Treatment with Valsartan in the Val-HeFT. Eur J Heart Fail. 2013
(Published online January 4, 2013, doi:10.1093/eurjhf/hfs205).

[3] Roger VL, Go AS, Lloyd-Jones DM, et al. Heart disease and stroke
statistics—2012 update: a report from the American Heart Association.
Circulation. 2012;125(1):e2–220.

[4] Heidenriech PA, Trogdon JG, Khavjou OA, et al. Forecasting the future of
cardiovascular disease in the United States: a policy statement from the
American Heart Association. Circulation. 2011;123(8):933–44.

CONTACT: Chuck Abdalian
         EVP & Chief Financial Officer
         (781) 434-0210

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