SHIRE PLC: Transaction in Own Shares

Transaction in Own Shares 
February 26, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company"),
announces that in accordance with the authority granted by shareholders at the
Company's Annual General Meeting on April 24, 2012 it purchased 28,551 of its
ordinary shares of 5 pence each ("Ordinary Shares") on February 25, 2013
through both direct purchases of Ordinary Shares and through the purchase of
Ordinary Shares underlying ADRs. The highest and lowest price paid for the
directly acquired Ordinary Shares was 2142.00 pence per share and 2116.00 pence
per share respectively and for those Ordinary Shares acquired through the
purchase of ADRs was 3207.00 cents per share and 3167.00 cents per share
The purchased shares will be held as treasury shares. Following the above
purchase, the Company holds 5,164,020 Ordinary Shares as treasury shares and
has 557,404,910 Ordinary Shares in issue (excluding treasury shares). 
The purchases were made by an independent third party which makes its trading
decisions independently of, and uninfluenced by the Company. The independence
of the third party enables the Company to continue to purchase Ordinary Shares
(including Ordinary Shares underlying ADRs) during close periods and other
prohibited periods, should they arise. The third party has been appointed by
the Company to make purchases to December 31, 2013. 
For further information please contact: 
Investor Relations                                                              
Eric Rojas                         +1 781 482 0999    
Sarah Elton-Farr               +44 1256 894157    
Notes to editors 
Shire enables people with life-altering conditions to lead better lives. 
Through our deep understanding of patients' needs, we develop and provide
healthcare in the areas of: 
* Behavioral Health and Gastro Intestinal conditions 

      * Rare Diseases
      * Regenerative Medicine
    as well as other symptomatic conditions treated by specialist physicians.

We aspire to imagine and lead the future of healthcare, creating value for
patients, physicians, policymakers, payors and our shareholders.

Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX 
Press Release                                      
-0- Feb/26/2013 07:00 GMT
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