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MERCK KGAA SAYS CILENGITIDE PHASE III TRIAL MISSES ENDPOINT(ENG)


(The following press release from Merck KGaA was received by e-mail. It was not confirmed by the sender.)

News Release

Your Contact Phyllis Carter Phone .+49 6151 72-3321

Merck: Phase III Trial of Cilengitide Did Not Meet Primary Endpoint in Patients With Newly Diagnosed Glioblastoma

• Patients with newly diagnosed glioblastoma and methylated MGMT gene promoter status did not live significantly longer when treated with cilengitide plus chemoradiotherapy

Darmstadt, Germany, February 25, 2013 – Merck announced today that the Phase III CENTRIC(a) trial of the investigational integrin inhibitor cilengitide did not meet its primary endpoint of significantly increasing overall survival when added to the current standard chemoradiotherapy regimen (temozolomide and radiotherapy). CENTRIC includes patients with newly diagnosed glioblastoma and methylated O(6)-methylguanine-DNA methyltransferase (MGMT) gene promoter status. The trial was planned and is being conducted in partnership with the European Organisation for Research and Treatment of Cancer (EORTC). Detailed trial results will be submitted for presentation at the American Society of Clinical Oncology (ASCO) 2013 Annual Meeting and publication in a peer-reviewed journal.

The complete news release can be downloaded at the following link: http://news.merck.de/N/0/BE2FE07AD630830EC1257B1D001F007B/$File/CENTRIC-E.pdf

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Merck KGaA ,Darmstadt, Germany External Communications E-mail: Media.Relations@merck.de Hotline: +49 (0) 6151/72-5000

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