(The following press release from Merck KGaA was received by e-mail. It 
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News Release 
Your Contact
Phyllis Carter
Phone .+49 6151 72-3321 
Merck: Phase III Trial of Cilengitide Did Not Meet Primary Endpoint in
Patients With Newly Diagnosed Glioblastoma 
• Patients with newly diagnosed glioblastoma and methylated MGMT gene
  promoter status did not live significantly longer when treated with
  cilengitide plus chemoradiotherapy 
Darmstadt, Germany, February 25, 2013 – Merck announced today that the
Phase III CENTRIC(a) trial of the investigational integrin inhibitor
cilengitide did not meet its primary endpoint of significantly increasing
overall survival when added to the current standard chemoradiotherapy
regimen (temozolomide and radiotherapy). CENTRIC includes patients with
newly diagnosed glioblastoma and methylated O(6)-methylguanine-DNA
methyltransferase (MGMT) gene promoter status. The trial was planned and is
being conducted in partnership with the European Organisation for Research
and Treatment of Cancer (EORTC). Detailed trial results will be submitted
for presentation at the American Society of Clinical Oncology (ASCO) 2013
Annual Meeting and publication in a peer-reviewed journal. 
The complete news release can be downloaded at the following link:$File/CENTRIC-E.pdf 
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Merck KGaA ,Darmstadt, Germany
External Communications
Hotline: +49 (0) 6151/72-5000 
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