TRADE NEWS: Agilent Technologies Introduces HaloPlex Exome Kits and SureCall Software

  TRADE NEWS: Agilent Technologies Introduces HaloPlex Exome Kits and SureCall

 New Offerings Extend Target-Enrichment Workflow, from Custom Assay Design to
                               Mutation Report

Business Wire

SANTA CLARA, Calif. -- February 21, 2013

Agilent Technologies Inc. (NYSE: A) today expanded its portfolio of
target-enrichment products with the introduction of HaloPlex exome kits and
SureCall software.

The new additions are designed to complement Agilent’s Web-based SureDesign
and custom HaloPlex gene panels to provide a complete, integrated workflow.

“These products simplify the sequencing of clinical research samples,” said
Olle Ericsson, Agilent director of marketing for DNA sequencing. “The HaloPlex
Exome delivers streamlined capture of all coding exons, with low input sample
requirements, on all Illumina sequencing platforms. Together with SureDesign,
and the SureCall software, these products constitute a very comprehensive
clinical research solution for target enrichment.”

The HaloPlex exome kit comprises about 2.5 million probes to provide efficient
and comprehensive coverage of the coding regions of the human genome with
minimal hands-on time and requires only 200 ng of input DNA.

“The HaloPlex exome provides an easy workflow for all-exon analysis enabling
short turnaround sequencing with low DNA input amounts,” said Dr. Wilfred van
IJcken, assistant professor at Erasmus MC and an early access user who also
will present at the 14th annual Advances in Genome Biology and Technology
meeting, Feb. 20-23, in Marco Island, Fla.

SureDesign, which has logged over 15,000 designs since it was launched in
October, enables clinical researchers to create a custom panel tailored to
their needs. With this interface, researchers can quickly generate
exceptionally flexible designs for high-performance, targeted resequencing,
using Agilent's HaloPlex and SureSelect systems. In just three simple steps,
researchers can create custom sequencing panels tailored to their specific
projects. To provide confidence in the analysis, any custom gene-sequencing
panel can be created based on the 2.5 million probes from the HaloPlex exome

SureCall data analysis software is designed to maximize clinical laboratory
throughput by dramatically simplifying the analysis workflow for
next-generation sequencing data. The software is fast, reliable and easy to
use, with a three-step workflow process that translates raw data into a report
with genetic variants classified and ranked in a matter of hours. Its
end-to-end capabilities make it more cost effective than other methods and
enable clinical researchers to focus on their results rather than cumbersome
analysis processes by eliminating the expensive, time-consuming data analysis
bottleneck. To download the new software free of charge, visit

About Agilent in Genomics

Agilent a global leader in target enrichment for next-generation sequencing
and genomic microarrays. The Agilent SureSelect and HaloPlex target-enrichment
systems enable researchers to easily choose which segments of a genome to
sequence, avoiding the time and expense needed to sequence the entire genome.
HaloPlex and its same-day sample-to-sequencer workflow is well suited for
next-generation desktop sequencers, whereas SureSelect’s ability to accurately
capture whole exomes and whole methylomes in a single reaction pairs well with
high-throughput next-generation sequencing systems. These are just two
products arising from Agilent’s expertise in synthesizing custom complex
mixtures of long oligonucleotide gained in microarray manufacturing.
Additional product lines built on this core technology include microarrays for
genome-wide measurement of gene expression and for comparative genomics
hybridization, as well as SureFISH, a highly specific and sensitive
oligonucleotide fluorescent in situ hybridization product line. In addition to
oligonucleotide-based products, Agilent offers a microfluidic bioanalyzer to
measure sample quality, a target-enrichment tool to speed next-generation
sequencing, and a full set of reagents, hardware, methods and bioinformatics
software for genomic experiments.

About Agilent Technologies

Agilent Technologies Inc. (NYSE: A) is the world’s premier measurement company
and a technology leader in chemical analysis, life sciences, diagnostics,
electronics and communications. The company’s 20,500 employees serve customers
in more than 100 countries. Agilent had revenues of $6.9 billion in fiscal
2012. Information about Agilent is available at

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