Repros Reports FDA Recommends Pivotal Study ZA-301 of Androxal(R) to be Completed as Originally Planned

Repros Reports FDA Recommends Pivotal Study ZA-301 of Androxal(R) to be
Completed as Originally Planned

  *FDA recommends all subjects in study ZA-301 complete as per the original
    protocol
  *FDA accepts additional enrollment into pivotal study ZA-302
  *SPA for both pivotal trials remains intact

THE WOODLANDS, Texas, Feb. 21, 2013 (GLOBE NEWSWIRE) -- Repros Therapeutics
Inc.^® (Nasdaq:RPRX) today provided a clinical update of its Androxal^® Phase
3 program following receipt of written guidance from the FDA.

The FDA has informed Repros to proceed with the analysis of ZA-301 as
previously planned, and that data should be evaluated both with and without
patients from the high enrolling site where the patients' baseline
characteristics appeared different from other sites in the study.

Additionally, the FDA accepted Repros' plan regarding study ZA-302 to enroll
additional patients. They also noted that Repros should revise the statistical
analysis plan and sample size to reflect increased enrollment. Study ZA-302
will also be analyzed with and without patients from the high enrolling site
where the patients' baseline characteristics appeared different from other
sites in the study.

Per the guidance from the FDA, the Special Protocol Assessment (SPA) will
remain intact with the revised trial parameters outlined above.

Top line data from study ZA-301 will be reported when available, as per the
Company's guidance given at the beginning of the year.

About Repros Therapeutics Inc.^®

Repros Therapeutics focuses on the development of small molecule drugs for
major unmet medical needs that treat male and female reproductive disorders.

The Repros Therapeutics Inc. logo is available at
http://www.globenewswire.com/newsroom/prs/?pkgid=7738

Any statements made by the Company that are not historical facts contained in
this release are forward-looking statements that involve risks and
uncertainties, including the ability to raise additional needed capital on a
timely basis in order for it to continue to fund development of its Androxal^®
and Proellex^® programs, have success in the clinical development of its
technologies, the reliability of interim results to predict final study
outcomes, and such other risks which are identified in the Company's most
recent Annual Report on Form 10-K and in any subsequent quarterly reports on
Form 10-Q. These documents are available on request from Repros Therapeutics
or at www.sec.gov. Repros disclaims any intention or obligation to update or
revise any forward-looking statements, whether as a result of new information,
future events or otherwise.

For more information, please visit the Company's website at
http://www.reprosrx.com.

CONTACT: Repros Therapeutics Inc.
         Joseph Podolski (281) 719-3447
         President and Chief Executive Officer
        
         Investor Relations:
         Thomas Hoffmann
         The Trout Group
         (646) 378-2931

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