Shire Regenerative Medicine and HealTogether Partner with Celebrity Chef Charles Mattocks to Raise Awareness of Diabetes and its

   Shire Regenerative Medicine and HealTogether Partner with Celebrity Chef
    Charles Mattocks to Raise Awareness of Diabetes and its Complications

The month-long "The Diabetic You" mobile bus tour will visit five Arizona and
California communities

PR Newswire

SAN DIEGO, Feb. 13, 2013

SAN DIEGO, Feb. 13, 2013 /PRNewswire/ --Shire plc (LSE: SHP, NASDAQ: SHPG),
the company's Regenerative Medicine business, its community education program
HealTogether, and celebrity chef Charles Mattocks announced today the launch
of "The Diabetic You" Mobile Tour. The multi-city tour will stop in Tucson,
AZ, Phoenix, AZ, San Diego, CA, Los Angeles and Santa Clara, CA, and feature
an array of experts traveling in a brightly-colored recreational vehicle (RV)
fully equipped for cooking demonstrations and information stations. "The
Diabetic You" tour is designed to provide visitors with easy access to
resources to help understand the complications of diabetes.

"Being aware of the complications related to diabetes may help prevent or
delay serious issues down the road," said Matthew Pauls, Senior Vice President
of Global Commercial Operations for Shire Regenerative Medicine, Inc. "By
partnering with Charles Mattocks, we are bringing information and access to
experts directly to the people who need it most. Our goal is to increase
awareness about the management and treatment of these issues."

Pauls continued, "With the right medical care and healthy life choices, people
with diabetes and those touched by diabetes can continue to enjoy life to the
fullest."

An avid advocate for patients with diabetes, Mattocks began creating 'The
Diabetic You,' a documentary and movement focused on educating and inspiring
people around the world. Also known as "The Poor Chef", Mattocks is the author
of Eat Cheap but Eat Well and is a frequent speaker on the topic of diabetes.

"After I was diagnosed with Type 2 diabetes, I made it a personal mission to
help educate the public about living healthier lives -- starting with healthy
eating," said Mattocks. "Together with Shire Regenerative Medicine, I hope to
increase awareness not only about the management of diabetes, but stop the
ravages of the deadly disease."

"The Diabetic You" Mobile Tour will include a day-long event in each city with
fun and interactive activities related to the management and treatment of
complications of diabetes, including cooking demonstrations by Mattocks.
Leading experts on diabetes will also be onsite to answer questions about
potential warning signs for common problems such as high blood pressure,
stroke, retinopathy and neuropathy. Additionally, "The Diabetic You" Mobile
Tour will be offering visitors a free year-long subscription to Diabetic
Living, one of the largest publications in diabetes health.

"The Diabetic You" Mobile Tour's schedule is as follows:

  oSaturday, February 23, 2013 – Tucson, AZ

       oTaking Control of Your Diabetes (TCOYD) Conference, Tucson Convention
         Center

  oSaturday, March 2, 2013 – Phoenix, AZ

       oDowntown Phoenix Public Market

  oFriday, March 8, 2013 – San Diego, CA

       oImperial Beach Farmer's Market, Imperial Beach

  oThursday, March 21, 2013 – Los Angeles, CA

       oDiabetic Foot Global Conference, Loews Hollywood Hotel

  oSaturday, March 23, 2013 – Santa Clara, CA

       oTCOYD Conference, Santa Clara Convention Center

About Charles Mattocks

Since his 2011 diagnosis with type 2 diabetes, "The Poor Chef" Charles
Mattocks has become an international advocate for diabetic testing, health,
and nutrition. Following early inspiration from his late uncle, Bob Marley,
Charles initially pursued an acting career culminating in an Emmy nomination
for his performance in "The Summer of Ben Tyler." Following acclaimed acting
success, Charles became a regular fixture as a chef on The Today Show, Good
Morning America, Martha Stewart, CNN, Dr. Oz, and became the best-selling
author of Eat Cheap but Eat Well. Determined to learn, educate, and help
others, Charles has since been able to use his celebrity chef status to work
with the American Diabetes Association, developing the newest ADA diabetic
cookbook and has recently been given the honor of being named a Hero and Blue
Circle Champion for the International Diabetes Federation. Ever the champion
for diabetic health and education, Charles's passion gave birth to The
Diabetic You, a documentary unveiling the influences that have left over 300
Million people worldwide with diabetes.

For further information please contact:

Media
Lindsey Hart (Shire Regenerative Medicine)
lhart@shire.com
+1 615 250 3311

Jennifer Chan (Edelman)
jennifer.chan@edelman.com
+1 415 229 7650

NOTES TO EDITORS

Shire enables people with life-altering conditions to lead better lives.

Through our deep understanding of patients' needs, we develop and provide
healthcare in the areas of:

  oBehavioral Health and Gastro Intestinal conditions
  oRare Diseases
  oRegenerative Medicine

as well as other symptomatic conditions treated by specialist physicians.

We aspire to imagine and lead the future of healthcare, creating value for
patients, physicians, policymakers, payors and our shareholders.

www.shire.com

FORWARD - LOOKING STATEMENTS - "SAFE HARBOR" STATEMENT UNDER THE PRIVATE
SECURITIES LITIGATION REFORM ACT OF 1995

Statements included in this announcement that are not historical facts are
forward-looking statements. Forward-looking statements involve a number of
risks and uncertainties and are subject to change at any time. In the event
such risks or uncertainties materialize, Shire's results could be materially
adversely affected. The risks and uncertainties include, but are not limited
to, that:

  oShire's products may not be a commercial success;
  orevenues from ADDERALL XR are subject to generic erosion;
  othe failure to obtain and maintain reimbursement, or an adequate level of
    reimbursement, by third-party payors in a timely manner for Shire's
    products may impact future revenues and earnings;
  oShire relies on a single source for manufacture of certain of its products
    and a disruption to the supply chain for those products may result in
    Shire being unable to continue marketing or developing a product or may
    result in Shire being unable to do so on a commercially viable basis;
  oShire uses third party manufacturers to manufacture many of its products
    and is reliant upon third party contractors for certain goods and
    services, and any inability of these third party manufacturers to
    manufacture products, or any failure of these third party contractors to
    provide these goods and services, in each case in accordance with its
    respective contractual obligations, could adversely affect Shire's ability
    to manage its manufacturing processes or to operate its business;
  othe development, approval and manufacturing of Shire's products is subject
    to extensive oversight by various regulatory agencies and regulatory
    approvals or interventions associated with changes to manufacturing sites,
    ingredients or manufacturing processes could lead to significant delays,
    increase in operating costs, lost product sales, an interruption of
    research activities or the delay of new product launches;
  othe actions of certain customers could affect Shire 's ability to sell or
    market products profitably and fluctuations in buying or distribution
    patterns by such customers could adversely impact Shire's revenues,
    financial conditions or results of operations;
  oinvestigations or enforcement action by regulatory authorities or law
    enforcement agencies relating to Shire's activities in the highly
    regulated markets in which it operates may result in the distraction of
    senior management, significant legal costs and the payment of substantial
    compensation or fines;
  oadverse outcomes in legal matters and other disputes, including Shire's
    ability to obtain, maintain, enforce and defend patents and other
    intellectual property rights required for its business, could have a
    material adverse effect on Shire's revenues, financial condition or
    results of operations;

and other risks and uncertainties detailed from time to time in Shire's
filings with the U.S. Securities and Exchange Commission, including its most
recent Annual Report on Form 10-K.

SOURCE Shire Regenerative Medicine

Website: http://www.shire.com
 
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