Opexa Therapeutics, Inc. Announces Pricing of Common Stock and Warrant Offering

  Opexa Therapeutics, Inc. Announces Pricing of Common Stock and Warrant

Business Wire

THE WOODLANDS, Texas -- February 7, 2013

Opexa Therapeutics, Inc. (NASDAQ:OPXA) a company developing Tcelna™
(imilecleucel-T), a novel T-cell therapy for multiple sclerosis (MS), today
announced it has priced an offering of shares of its common stock and warrants
to purchase common stock in a private registered offering of 1,083,334 units
at a price of $3.00 per unit, for gross proceeds of $3,250,000. Each unit
consists of one share of common stock and a warrant to purchase one-half
(0.50) of a share of common stock. The shares of common stock and warrants are
immediately separable and will be issued separately such that no units will be
issued. The warrants are exercisable immediately upon issuance, have a
four-year term and an exercise price of $3.00 per share. The offering is
expected to close on or about February 11, 2013, subject to customary closing
conditions. All of the shares in the offering are to be sold by Opexa.

The net proceeds from these financing arrangements will be used for working
capital and general corporate purposes, including the continued conduct of the
Abili-T clinical study, Opexa's ongoing Phase 2b clinical trial of Tcelna in
Secondary Progressive MS patients.

Dawson James Securities, Inc. acted as exclusive placement agent in connection
with the offering.

This offering is being conducted pursuant to a shelf registration statement
(File No. 333-185001) that was declared effective by the U.S. Securities and
Exchange Commission on December 05, 2012. A prospectus supplement related to
the public offering will be filed with the Securities and Exchange Commission
(SEC). When filed with the SEC, copies of the prospectus supplement and the
accompanying base prospectus relating to this offering may be obtained at the
SEC's website at http://www.sec.gov or by request at Dawson James Securities
by e-mailing placements@djsiny.com.

About Multiple Sclerosis (MS)

MS is a chronic, inflammatory condition of the central nervous system and is
the most common, non-traumatic, disabling neurological disease in young
adults. It is estimated that approximately two million people have MS

While symptoms can vary, the most common symptoms of MS include blurred
vision, numbness or tingling in the limbs and problems with strength and
coordination. The relapsing forms of MS are the most common.

About Tcelna

Tcelna is a potential personalized therapy that is under development to be
specifically tailored to each patient's disease profile. Tcelna is
manufactured using ImmPath^™, Opexa's proprietary method for the production of
a patient-specific T-cell immunotherapy, which encompasses the collection of
blood from the MS patient, isolation of peripheral blood mononuclear cells,
generation of an autologous pool of myelin-reactive T-cells (MRTCs) raised
against selected peptides from myelin basic protein (MBP), myelin
oligodendrocyte glycoprotein (MOG) and proteolipid protein (PLP), and the
return of these expanded, irradiated T-cells back to the patient. These
attenuated T-cells are reintroduced into the patient via subcutaneous
injection to trigger a therapeutic immune system response.

Opexa is currently conducting a Phase IIb study of Tcelna. Named Abili-T, the
trial is a randomized, double-blind, placebo-controlled clinical study in
patients who demonstrate evidence of disease progression without associated
relapses. The trial is expected to enroll 180 patients at approximately 30
leading clinical sites in the U.S. and Canada with each patient receiving two
annual courses of Tcelna treatment consisting of five subcutaneous injections
per year. The trial’s primary efficacy outcome is the percentage of brain
volume change (atrophy) at 24 months. Study investigators will also measure
several important secondary outcomes commonly associated with MS, including
disease progression as measured by the Expanded Disability Status Scale
(EDSS), annualized relapse rate and changes in disability as measured by EDSS
and the MS Functional Composite.

About Opexa

Opexa is dedicated to the development of patient-specific cellular therapies
for the treatment of autoimmune diseases such as MS. The Company’s leading
therapy candidate, Tcelna^™, is a personalized cellular immunotherapy that is
in Phase IIb clinical development for MS. Tcelna is derived from T-cells
isolated from peripheral blood, expanded ex vivo, and reintroduced into the
patients via subcutaneous injections. This process triggers a potent immune
response against specific subsets of autoreactive T-cells known to attack

For more information visit the Opexa Therapeutics website at

Cautionary Statement Relating to Forward-Looking Information for the Purpose
of "Safe Harbor" Provisions of the Private Securities Litigation Reform Act of

This press release contains forward-looking statements which are made pursuant
to the safe harbor provisions of Section 27A of the Securities Act of 1933, as
amended, and Section 21E of the Securities Exchange Act of 1934, as amended.
The words “expects,” “believes,” “may,” “could,” and similar expressions are
intended to identify forward-looking statements. The forward-looking
statements in this release do not constitute guarantees of future performance.
Investors are cautioned that statements in this press release which are not
strictly historical statements, including, without limitation, statements
regarding the development of the Company’s product candidate, Tcelna
(imilecleucel-T), constitute forward-looking statements. Such forward-looking
statements are subject to a number of risks and uncertainties that could cause
actual results to differ materially from those anticipated, including, without
limitation, risks associated with: the proposed financing, and whether or not
the closing conditions are satisfied and the Company is able to receive the
anticipated proceeds; the success of our clinical trials (including the Phase
IIb trial for Tcelna (imilecleucel-T) in SPMS); our ability to raise
additional capital to continue our development programs (including to
undertake and complete any ongoing or further clinical studies for Tcelna; the
efficacy of Tcelna for any particular indication, such as for relapsing
remitting MS or secondary progressive MS; our compliance with all Food and
Drug Administration regulations; our ability to obtain, maintain and protect
intellectual property rights (including for Tcelna); and other risks detailed
in our filings with the Securities and Exchange Commission. These
forward-looking statements speak only as of the date made. We assume no
obligation or undertaking to update any forward-looking statements to reflect
any changes in expectations with regard thereto or any change in events,
conditions or circumstances on which any such statement is based. You should,
however, review additional disclosures we make in our reports filed with the
Securities and Exchange Commission, including our Annual Report on Form 10-K
for the year ended December 31, 2011 and our Quarterly Report on Form 10-Q for
the quarter ended September 30, 2012.


Opexa Therapeutics, Inc.
Neil K. Warma
The Trout Group
Adam Cutler
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