The Institute for Systems Biology and AB SCIEX Partner to Help Make Medical Care More Predictive and Personalized

  The Institute for Systems Biology and AB SCIEX Partner to Help Make Medical
  Care More Predictive and Personalized

   Collaboration with National Medal of Science award winner to accelerate
  development of new analytical strategies for proteomics mass spectrometry
                    using “game-changing” SWATH technology

Business Wire

FRAMINGHAM, Mass. -- February 6, 2013

Medical care is expected to become more personalized and better able to help
prevent the onset of diseases in the future, thanks to groundbreaking research
into P4 medicine underway by world-renowned scientists at the Institute for
Systems Biology, including National Medal of Science award winner Leroy Hood,
MD, PhD., and ISB proteomics research director, Robert Moritz, PhD., and now
supported by a new collaboration with AB SCIEX, a global leader in analytical

ISB and AB SCIEX have signed a multi-year agreement to collaborate on the
development of methods and technology in proteomics mass spectrometry with the
goal to redefine biomarker research and complement genomics through fully
comprehensive quantitative proteomics analysis. This will help advance the
development of a new approach to medical care.

ISB’s concept of P4 medicine promises to provide deep insight into disease
mechanisms on the path to develop medical care that is predictive,
personalized, preventive and participatory (the four “P”s) – a pioneering
vision that requires a combination of analytical tools, workflows, databases,
collaborations and computational strategies.

“With breakthroughs in translating research into clinical relevance, P4
medicine is expected to enable the creation of a virtual cloud of billions of
data points around each individual as the basis for straightforward
predictions about health and disease,” said Dr. Hood, ISB president and
co-founder. In December, he was named a recipient of the National Medal of
Science, which is the highest honor the President of the United States can
bestow on a scientist, in recognition of visionary work for the advancement of

Led by Dr. Hood, ISB’s groundbreaking research is being accelerated by SWATH™
Acquisition, a data-independent acquisition (DIA) mass spectrometry workflow
that can quantify virtually all detectable peptides and proteins in a complex
sample – all in a single analysis.

“Quantifying enormous numbers of protein analytes at the same time is a
critical need to accelerate P4 medicine and the democratization of proteomics,
a revolution that is akin to the sequencing of the genome and the
democratization of DNA,” added Dr. Hood. “SWATH is a game-changing technique
that essentially acts as a protein microarray and is the most reproducible way
to generate comprehensive quantitation of the entire proteome. It generates a
digital record of the entire proteome that can be mined retrospectively for
years to come.”

ISB’s know-how in systems biology and informatics will support the development
of SWATH libraries, similar to its highly regarded SRMAtlas project for the
human proteome, pioneered by Rob Moritz and his collaborators, and the
proteomes of other clinically-relevant organisms. “With complete proteome-wide
libraries, ISB provides the basis to support comprehensive SWATH analysis,”
said Dr. Moritz, ISB Proteomics Research Director.

Committed to an open policy of sharing data and methods, ISB will make the
SWATH libraries available to the global scientific community to accelerate the
use of SWATH for other biological research. Utilizing the depth in proteomics
technology development and underpinned by the extensive proteomics
computational resources in data interpretation tools, standards initiatives
and database development under the leadership of Dr. Moritz, ISB will develop
new SWATH technologies and tools to enable the community to quickly adopt
comprehensive quantitative proteome analysis.

“Having the proteomics data standardized across laboratories and across
samples really enables us to quantitate entire proteomes at a level that
hasn’t been done before,” said Dr. Moritz. “We aim to define markers that can
predict whether a patient will respond to a certain treatment or not, and
applying SWATH will play a big part in taking our advancements to another
level. Not only can we now complement the breadth of genomics, but we will
have the much-needed libraries and software development going forward to make
data-sharing quite easier and standardized.”

As a trusted partner with academic researchers, AB SCIEX has formed this
strategic alliance with Dr. Hood, Dr. Moritz and their distinguished ISB
colleagues through the AB SCIEX Academic Partnership Program to help broaden
the availability of new technologies to researchers delving into omics
research around the world.

“What ISB does with SWATH will set a new benchmark in proteomics research,”
said Rainer Blair, President of AB SCIEX. “Our collaboration with ISB will
help drive SWATH into the mainstream of analytical science and make
comprehensive, reproducible and simplified omics data more accessible to
biologists around the world.”

ISB will be using the AB SCIEX TripleTOF^® 5600^± System and an Eksigent
ekspert™ nano-LC 400 System as the instrument platforms on which to conduct
the protein identification and quantitation. The TripleTOF 5600^+ System
provides the high speed necessary for SWATH Acquisition. TripleTOF technology
combines high speed and high sensitivity with high resolution and accurate
mass. ISB also plans to use SelexION™ technology, a recent advancement in
differential ion mobility, in the future to advance its research.

About P4 Medicine

P4 Medicine – i.e. medicine that is Predictive, Preventive, Personalized and
Participatory -- is emerging out of the convergence of systems biology, the
increasing activation of networked consumers and the digital revolution in
communications and information technology. Historically, human biology was a
black box about which little was known apart from surface manifestations of
disease. That black box is now being opened by systems biology. P4 medicine
looks inside that black box for each individual using the pioneering
capability of systems biology to generate actionable understandings of disease
and wellness as a continuum of network states unique in time and space to each
individual human being.

About the Institute for Systems Biology

The Institute for Systems Biology (ISB) is a world-renowned, non-profit
research institute headquartered in Seattle that is dedicated to the study and
application of systems biology. Founded in 2000,ISB seeks to unravel the
mysteries of biology while identifying strategies for predicting and
preventing diseases, solving energy and environmental issues, and improving
K-12 science education. ISB's systems approach integrates biology, computation
and technological development, enabling scientists to analyze all elements in
a biological system rather than one gene or protein at a time. ISB has 10
faculty members and about 230 staff. Visit ISB at or on
Twitter @ISBUSA and Facebook.


AB SCIEX helps to improve the world we live in by enabling scientists and
laboratory analysts to push the limits in their field and address the complex
analytical challenges they face. The company’s global leadership and
world-class service and support in the mass spectrometry industry have made it
a trusted partner to thousands of the scientists and lab analysts worldwide
who are focused on basic research, drug discovery and development, food and
environmental testing, forensics and clinical research. With over 25 years of
proven innovation, AB SCIEX excels by listening to and understanding the
ever-evolving needs of its customers to develop reliable, sensitive and
intuitive solutions that continue to redefine what is achievable in routine
and complex analysis. For more information about the company, go to Follow AB SCIEX on Twitter @ABSCIEX, Facebook and LinkedIn.

© 2013. AB SCIEX. AB Sciex Instruments Are For Research Use Only. Not for use
in diagnostic procedures. The trademarks mentioned herein are the property of
AB SciexPte. Ltd. or their respective owners. AB SCIEX^TM is being used under

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Anthony Petrucci, 1-508-383-7961
Director of Public Relations
Hsiao-Ching Chou, 1-206-732-2157
Director of Communications
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