Teva Announces First Patient Enrolled in Largest Clinical Study to Date Evaluating AZILECT® for Mild Cognitive Impairment in

  Teva Announces First Patient Enrolled in Largest Clinical Study to Date
  Evaluating AZILECT® for Mild Cognitive Impairment in Parkinson's Disease

Business Wire

JERUSALEM -- February 5, 2013

Teva Pharmaceutical Industries Ltd. (NYSE: TEVA) announced today enrollment of
the first patient in the MODERATO study – a Phase IV clinical study designed
to evaluate the effect of AZILECT^® (rasagiline tablets) on cognitive function
in adults with mild cognitive impairment (MCI) in Parkinson's disease

“Cognitive impairment in PD is a major cause of disability and increased care
partner burden,” said Robert A. Hauser, M.D., M.B.A., Director, Parkinson's
Disease & Movement Disorders Center at the University of South Florida and
co-primary investigator of the study. “As currently there are no available
treatments for cognitive impairment in Parkinson's disease, any therapy that
may demonstrate benefit would be welcomed for this significant unmet need.”

The MODERATO study (Multicenter, Randomized, Double-Blind, Placebo-Controlled
Study to Assess the Effect of Rasagiline on Cognition in Patients with
Parkinson’s disease) is the largest trial to-date to evaluate a treatment for
PD-MCI. The multicenter study will evaluate the effect of rasagiline on
cognitive function in adults with PD-MCI, as assessed by the Scales for
Outcomes of Parkinson's Disease-Cognition (SCOPA-COG) after 24 weeks of
treatment and will enroll approximately 170 patients at 30 sites across the
United States.

“PD-MCI is common in non-demented PD patients and is associated with
increasing age, disease duration and disease severity,” said Michael Hayden,
M.D., President of Global R&D and Chief Scientific Officer for Teva
Pharmaceutical Industries, Ltd. “MODERATO demonstrates Teva's ongoing
commitment to research with AZILECT and the development of products aimed at
meeting the specific needs of the CNS community.”

PD is a slowly progressing degenerative disorder of the brain, characterized
by tremor, stiffness, slowness of movement, and impaired balance. An estimated
five million people worldwide suffer from the disease, with an average age of
onset of about 60 years.


AZILECT^® (rasagiline tablets) is indicated for the treatment of the signs and
symptoms of Parkinson's disease (PD) both as initial therapy alone and to be
added to levodopa later in the disease.

Patients should not take AZILECT^® if they are taking meperidine, tramadol,
methadone, propoxyphene, dextromethorphan, St. John’s wort, cyclobenzaprine,
or other monoamine oxidase inhibitors (MAOIs), as it could result in a serious
reaction. Patients should inform their physician if they are taking, or
planning to take, any prescription or over-the-counter drugs, especially
antidepressants and ciprofloxacin. Patients with moderate to severe liver
disease should not take AZILECT^®. Patients should not exceed a dose of 1 mg
per day of AZILECT^® in order to prevent a possibly dangerous increase in
blood pressure.

Side effects seen with AZILECT^® alone are flu syndrome, joint pain,
depression, and indigestion; and when taken with levodopa are uncontrolled
movements (dyskinesia), accidental injury, weight loss, low blood pressure
when standing, vomiting, anorexia, joint pain, abdominal pain, nausea,
constipation, dry mouth, rash, abnormal dreams, and fall.

See additional important information at For
hardcopy releases, please see enclosed full prescribing information.

AZILECT^® is currently available in more than 40 countries worldwide,
including the U.S., Canada, Israel, Mexico, and all EU countries. Teva has a
long-term agreement for the joint development and marketing of AZILECT^® in
Europe and some additional markets with H. Lundbeck A/S. In North America,
AZILECT^® is marketed by Teva's wholly-owned subsidiary, Teva Neuroscience,
Inc. (

About Teva

Teva Pharmaceutical Industries Ltd. (NYSE: TEVA) is a leading global
pharmaceutical company, committed to increasing access to high-quality
healthcare by developing, producing and marketing affordable generic drugs as
well as innovative and specialty pharmaceuticals and active pharmaceutical
ingredients. Headquartered in Israel, Teva is the world's leading generic drug
maker, with a global product portfolio of more than 1,000 molecules and a
direct presence in about 60 countries. Teva's branded businesses focus on CNS,
oncology, pain, respiratory and women's health therapeutic areas as well as
biologics. Teva currently employs approximately 46,000 people around the world
and reached $18.3 billion in net revenues in 2011.

Teva's Safe Harbor Statement under the U. S. Private Securities Litigation
Reform Act of 1995:

This release contains forward-looking statements, which express the current
beliefs and expectations of management. Such statements are based on
management’s current beliefs and expectations and involve a number of known
and unknown risks and uncertainties that could cause our future results,
performance or achievements to differ significantly from the results,
performance or achievements expressed or implied by such forward-looking
statements, including statements relating to the results of the GALA phase III
trial and the potential efficacy or future market or marketability of
glatiramer acetate 40 mg/1 ml. Following further analysis, Teva's
interpretation of the results could differ materially depending on a number of
factors, and we caution investors not to place undue reliance on the
forward-looking statements contained in this press release as there can be no
guarantee that the results from the phase III trial discussed in this press
release will be confirmed upon full analysis of the results of the trial and
additional information relating to the safety, efficacy or tolerability of
glatiramer acetate 40 mg/1 ml may be discovered upon further analysis of data
from the phase III trial. Even if the results described in this release are
confirmed upon full analysis of the GALA study, we cannot guarantee that
glatiramer acetate 40 mg/1 ml will be approved for marketing in a timely
manner, if at all, by regulatory authorities in the EU or in the U.S.
Important factors that could cause or contribute to such differences include
risks relating to: our ability to develop and commercialize additional
pharmaceutical products, competition for our innovative products, especially
Copaxone® (including competition from innovative orally-administered
alternatives, as well as from potential generic equivalents), competition for
our generic products (including from other pharmaceutical companies and as a
result of increased governmental pricing pressures), competition for our
specialty pharmaceutical businesses, our ability to achieve expected results
through our innovative R&D efforts, the effectiveness of our patents and other
protections for innovative products, decreasing opportunities to obtain U.S.
market exclusivity for significant new generic products, our ability to
identify, consummate and successfully integrate acquisitions (including the
acquisition of Cephalon), the effects of increased leverage as a result of the
acquisition of Cephalon, the extent to which any manufacturing or quality
control problems damage our reputation for high quality production and require
costly remediation, our potential exposure to product liability claims to the
extent not covered by insurance, increased government scrutiny in both the
U.S. and Europe of our agreements with brand companies, potential liability
for sales of generic products prior to a final resolution of outstanding
patent litigation, including that relating to the generic version of
Protonix®, our exposure to currency fluctuations and restrictions as well as
credit risks, the effects of reforms in healthcare regulation and
pharmaceutical pricing and reimbursement, any failures to comply with complex
Medicare and Medicaid reporting and payment obligations, governmental
investigations into sales and marketing practices (particularly for our
specialty pharmaceutical products), uncertainties surrounding the legislative
and regulatory pathway for the registration and approval of
biotechnology-based products, adverse effects of political or economical
instability, major hostilities or acts of terrorism on our significant
worldwide operations, interruptions in our supply chain or problems with our
information technology systems that adversely affect our complex manufacturing
processes, any failure to retain key personnel (including Cephalon employees)
or to attract additional executive and managerial talent, the impact of
continuing consolidation of our distributors and customers, variations in
patent laws that may adversely affect our ability to manufacture our products
in the most efficient manner, potentially significant impairments of
intangible assets and goodwill, potential increases in tax liabilities, the
termination or expiration of governmental programs or tax benefits,
environmental risks and other factors that are discussed in our Annual Report
on Form 20-F for the year ended December 31, 2011 and in our other filings
with the U.S. Securities and Exchange Commission. Forward-looking statements
speak only as of the date on which they are made and the Company undertakes no
obligation to update or revise any forward-looking statement, whether as a
result of new information, future events or otherwise.


United States
Kevin C. Mannix, (215) 591-8912
Tomer Amitai, 972 (3) 926-7656
Hadar Vismunski-Weinberg, 972 (3) 926-7687
United States
Denise Bradley, (215) 591-8974
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