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News Release 
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Phyllis Carter
+49 6151 72-7144 
Merck Initiates TH-302 Phase III MAESTRO Study in Patients With Locally
Advanced or Metastatic Pancreatic Adenocarcinoma 
• Pivotal Phase III study with investigational hypoxia-targeted drug aims
 enroll 660 patients 
Darmstadt, Germany, January 25, 2013 – Merck today announced the initiation
of the global Phase III MAESTRO study, assessing the efficacy and safety of
investigational hypoxia-targeted drug TH-302 in combination with
gemcitabine in patients with previously untreated, locally advanced
unresectable or metastatic pancreatic adenocarcinoma. The study is being
carried out pursuant to a global licensing and co-development agreement for
TH-302 between Merck and Threshold Pharmaceuticals Inc., which includes an
option for Threshold to co-commercialize in the U.S. MAESTRO stands for
TH-302 in the treatment of MetastAtic or unrESectable pancreaTic
The complete news release can be downloaded at the following link:$File/MaestroEng.pdf 
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