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MERCK KGAA STARTS TH-302 PHASE III STUDY ON PANCREAS CANCER(ENG)


(The following press release from Merck KGaA was received by e-mail. It was not confirmed by the sender.)

News Release

Your Contact Phyllis Carter +49 6151 72-7144

Merck Initiates TH-302 Phase III MAESTRO Study in Patients With Locally Advanced or Metastatic Pancreatic Adenocarcinoma

• Pivotal Phase III study with investigational hypoxia-targeted drug aims to enroll 660 patients

Darmstadt, Germany, January 25, 2013 – Merck today announced the initiation of the global Phase III MAESTRO study, assessing the efficacy and safety of investigational hypoxia-targeted drug TH-302 in combination with gemcitabine in patients with previously untreated, locally advanced unresectable or metastatic pancreatic adenocarcinoma. The study is being carried out pursuant to a global licensing and co-development agreement for TH-302 between Merck and Threshold Pharmaceuticals Inc., which includes an option for Threshold to co-commercialize in the U.S. MAESTRO stands for TH-302 in the treatment of MetastAtic or unrESectable pancreaTic adenocaRcinOma.

The complete news release can be downloaded at the following link: http://news.merck.de/N/0/C129EE9000B3AE31C1257AFE002AF6CC/$File/MaestroEng.pdf

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Merck KGaA External Communications E-mail: Media.Relations@merck.de Hotline: +49 (0) 6151/72-5000

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