Faruqi & Faruqi, LLP Encourages Investors Who Suffered $100,000 In Losses Investing In Isis Pharmaceuticals, Inc. To Contact The

  Faruqi & Faruqi, LLP Encourages Investors Who Suffered $100,000 In Losses
         Investing In Isis Pharmaceuticals, Inc. To Contact The Firm

PR Newswire

NEW YORK, Jan. 19, 2013

NEW YORK, Jan. 19, 2013 /PRNewswire/ --Faruqi & Faruqi, LLP, a leading
national securities law firm, is investigating potential securities fraud at
Isis Pharmaceuticals, Inc. ("Isis" or the "Company") (NasdaqGS: ISIS).

(Logo: http://photos.prnewswire.com/prnh/20120119/MM38856LOGO)

The investigation focuses on whether the Company and its executives violated
federal securities laws by misleading investors to believe that one of the
drugs in Isis' product pipeline, Kynamro, would receive approval from the U.S.
Food and Drug Administration ("FDA") through a bevy of materially false and
misleading statements regarding the safety and efficacy of the drug, as well
as purportedly affirmative results from Kynamro's phase three clinical trial.

On October 16, 2012, an FDA advisory committee posted information on the FDA's
website noting that in recent patient studies, 3.1 percent of patients, or 23
people treated with Kynamro developed tumors and three of them died, while
only 0.9 percent, or two patients getting a placebo developed tumors. The
Endocrinologic and Metabolic Drugs Advisory Committee also noted liver and
blood vessel cancers were seen in earlier tests of the drug conducted on mice.

As a result of this disappointing news, the price per share of Isis
Pharmaceuticals common stock declined $2.88, or nearly 22%, to close that day
at $10.27, on heavy trading volume.

Request more information now by clicking here: www.faruqilaw.com/ISIS. There
is no cost or obligation to you.

Take Action

If you purchased Isis stock or options between March 29, 2012 and October 15,
2012 and would like to discuss your legal rights, visit
www.faruqilaw.com/ISIS. You can also contact us by calling Richard Gonnello
or Francis McConville toll free at 877-247-4292 or at 212-983-9330 or by
sending an e-mail to rgonnello@faruqilaw.com or fmcconville@faruqilaw.com.
Faruqi & Faruqi, LLP also encourages anyone with information regarding Isis'
conduct to contact the firm, including whistleblowers, former employees,
shareholders and others.

Attorney Advertising. The law firm responsible for this advertisement is
Faruqi & Faruqi, LLP (www.faruqilaw.com). Prior results do not guarantee or
predict a similar outcome with respect to any future matter. We welcome the
opportunity to discuss your particular case. All communications will be
treated in a confidential manner.

FARUQI & FARUQI, LLP
369 Lexington Avenue, 10th Floor
New York, NY 10017
Attn: Richard Gonnello, Esq.
rgonnello@faruqilaw.com
Francis McConville, Esq.
fmcconville@faruqilaw.com
Telephone: (877) 247-4292 or (212) 983-9330



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Website: www.faruqilaw.com