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The Zacks Analyst Blog Highlights: Isis Pharmaceuticals, Inc., Sanofi, GlaxoSmithKline, OncoGenex and Teva Pharmaceuticals

    The Zacks Analyst Blog Highlights: Isis Pharmaceuticals, Inc., Sanofi,
             GlaxoSmithKline, OncoGenex and Teva Pharmaceuticals

PR Newswire

CHICAGO, Jan. 14, 2013

CHICAGO, Jan. 14, 2013 /PRNewswire/ --Zacks.com announces the list of stocks
featured in the Analyst Blog. Every day the Zacks Equity Research analysts
discuss the latest news and events impacting stocks and the financial markets.
Stocks recently featured in the blog include Isis Pharmaceuticals (ISIS),
Sanofi (SNY), GlaxoSmithKline(GSK), OncoGenex (OGXI) and Teva
Pharmaceuticals(TEVA).

(Logo: http://photos.prnewswire.com/prnh/20101027/ZIRLOGO)

Today, Zacks is promoting its ''Buy'' stock recommendations. Four daily picks
are offered free.

Here are highlights from Monday's Analyst Blog:

Isis Pharma Updates on Pipeline

Isis Pharmaceuticals, Inc. (ISIS) recently provided an update on its pipeline.
Isis Pharma boasts of a robust pipeline. The company believes 5 of its
pipeline candidates can get approval within the next five years. Isis Pharma
expects data (phase II or phase III) on nine of its pipeline candidates in
2013.

Isis Pharma's lead pipeline candidate, Kynamro (mipomersen), is a second
generation compound being developed in collaboration with Sanofi (SNY) for the
treatment of familial hypercholesterolemia (FH). Isis Pharma received a major
boost in October 2012 when the Food and Drug Administration's (FDA)
Endocrinologic and Metabolic Drugs Advisory Committee voted (9 - 6) in favor
of approving the company's lead pipeline candidate, Kynamro. A response from
the FDA should be out by Jan 29, 2013.

However, we note that in Dec 2012, the Committee for Medicinal Products for
Human Use (CHMP) of the European Medicines Agency (EMA) rendered a negative
opinion on the approval of Kynamro.

Another interesting candidate at Isis Pharma is ISIS-TTRRx. The candidate is
being co-developed with GlaxoSmithKline (GSK) for the treatment of
transthyretin (TTR) amyloidosis. The companies plan to initiate a
registration-directed phase II/III study evaluating the efficacy of ISIS-TTRRx
on neurological dysfunction and quality-of-life in patients with familial
amyloid polyneuropathy (FAP), a type of TTR amyloidosis, shortly. The
candidate received fast track designation from the FDA.

Other promising candidates in Isis Pharma's pipeline include oncology drug,
OGX-011 and EXC 001 for unwanted scarring. For OGX-011, the company has
partnered with OncoGenex (OGXI) and Teva Pharmaceuticals (TEVA). Data from a
phase III trial evaluating OGX-011 in prostate cancer is expected to be
released at the end of 2013.

Isis Pharma carries a Zacks Rank #3 (Hold) in the short run. Though impressed
by Isis Pharma's pipeline, we expect investor focus to remain on the FDA's
decision on Kynamro.

Today, Zacks is promoting its ''Buy'' stock recommendations. Four daily picks
are offered free.

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