LifeVantage Announces Protandim(R) Subject of New Peer-Reviewed Study
Free Radical Biology and Medicine Reports Favorable Results in Published Heart
SALT LAKE CITY, Jan. 2, 2013 (GLOBE NEWSWIRE) -- LifeVantage Corporation
(Nasdaq:LFVN), a company dedicated to helping people achieve healthy living
through a combination of a compelling business opportunity and scientifically
validated products, including its patented dietary supplement Protandim^®, the
Nrf2 Synergizer^®, announced today that a new peer-reviewed study involving
Protandim was published in the November 2012 issue of the scientific journal,
Free Radical Biology and Medicine.
Protandim, comprised of five highly synergistic herbal ingredients, has been
shown in earlier studies to activate the transcription factor Nrf2, a signal
to the cell's DNA to regulate a network of protective genes. The new study
titled, "Upregulation of phase II enzymes through phytochemical activation of
Nrf2 protects cardiomyocytes against oxidant stress," further investigates
Protandim's ability to induce protective responses in cultured mouse heart
"This newest research, one among numerous published peer-reviewed studies
involving Protandim, provides further evidence of the scientific integrity of
our healthy living products," said LifeVantage President and CEO Douglas C.
Robinson. "As we expand our international operations and broaden our product
range, we will continue to encourage and support rigorous scientific
examination of the function and benefits of our offerings."
According to Darlene Walley, Ph.D., LifeVantage Chief Science Officer, "This
study, conceived and conducted by researchers at two Colorado universities,
shows the remarkable academic interest of the scientific community in
Protandim and demonstrates Protandim's powerful ability to activate Nrf2, an
important pathway for reducing and protecting cells against oxidative stress.
We are honored to be involved in cutting edge research regarding Nrf2,
Protandim's robust impact on its activation, and the important positive ways
that Nrf2 activation can potentially impact health and reduce oxidative
The key findings of this latest research are:
1) Protandim treatment of cultured HL-1 cells (mouse cardiomyocytes)
caused Nrf2 activation, as measured by nuclear accumulation of Nrf2 and by
increased expression of phase II enzymes heme oxygenase-1, superoxide
dismutase-1, and glutathione reductase.
2) Protandim treatment of cultured HL-1 cells caused protection against
hydrogen peroxide-induced apoptosis, and it was shown that the Nrf2 pathway
was required for this protective effect.
3) Exposure of HL-1 cells to oxidative stress activates Nrf2, but
treatment of HL-1 cells with Protandim activates Nrf2 more robustly than
does oxidative stress."This is important," Dr. Walley noted, "because it
supports the hypothesis that Protandim may protect heart cells against
oxidative challenges above and beyond the natural adaptive responses by
cells to oxidative stress."
Authored by Danielle J. Reuland, Shadi Khademi, Christopher J. Castle,
Benjamin F. Miller and Karyn L. Hamilton of the Department of Health and
Exercise Science, Colorado State University; David C. Irwin of the
Cardiovascular Pulmonary Research Group, Division of Cardiology, School of
Medicine, University of Colorado Denver; and Joe M. McCord of Pulmonary
Sciences and Critical Care Medicine, University of Colorado Denver and
LifeVantage Corporation. The study may be found at
Under the Dietary Supplement Health and Education Act, Protandim is considered
a "dietary supplement". LifeVantage products are not intended to treat, cure,
prevent or mitigate any disease.
About LifeVantage Corporation
LifeVantage, (LFVN), a leader in Nrf2 science and the maker of Protandim^®,
the Nrf2 Synergizer^® patented dietary supplement, is a science based
nutraceutical company. LifeVantage is dedicated to visionary science that
looks to transform wellness and anti-aging internally and externally with
products that dramatically reduce oxidative stress at the cellular level. The
Company was founded in 2003 and is headquartered in Salt Lake City, UT.
The LifeVantage Corporation logo is available at
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CONTACT: Investor Relations Contact:
Cindy England (801) 432-9036
Director of Investor Relations
John Mills (310) 954-1105
Senior Managing Director, ICR, LLC
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