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SHIRE PLC: Total Voting Rights


Total Voting Rights

January 2, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company"), in accordance with DTR 5.6.1 of the FSA's Disclosure and Transparency Rules, notifies the market of the following:

At close of business on December 31, 2012, the Company's issued ordinary share capital comprised 558,914,764 ordinary shares of 5 pence each with voting rights and a further 3,631,571 ordinary shares held in treasury.

Therefore the total number of voting rights in the Company is 558,914,764. This is the figure which should be used by shareholders as the denominator for the calculations by which they will determine if they are required to notify their interest in, or a change to their interest in, the Company under the Financial Services Authority's Disclosure and Transparency Rules.

Tony Guthrie Deputy Company Secretary

For further information please contact:

Investor Relations

Eric Rojas erojas@shire.com +1 781 482 0999

Sarah Elton-Farr seltonfarr@shire.com +44 1256 894157

Notes to editors

Shire enables people with life-altering conditions to lead better lives.

Through our deep understanding of patients' needs, we develop and provide healthcare in the areas of:

* Behavioral Health and Gastro Intestinal conditions


      * Rare Diseases
      * Regenerative Medicine
    as well as other symptomatic conditions treated by specialist physicians.

We aspire to imagine and lead the future of healthcare, creating value for
patients, physicians, policymakers, payors and our shareholders.

Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX

Press Release

www.shire.com

END

-0- Jan/02/2013 12:00 GMT

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