SHIRE PLC: Director/PDMR Shareholding

PDMR Share Dealing

December 20, 2012 - Shire plc (LSE: SHP, NASDAQ: SHPG) announces that on December 19, 2012, Ann Judge exercised a Stock Appreciation Right Award granted under the Shire Portfolio Share Plan and sold the resulting American Depository Shares ("ADSs"). One ADS is equal to three Shire plc ordinary shares of 5p each.

Number of Exercise Number of ADSs Sale price

price received and ADSs exercised sold

15,000 $58.67 5,635 $93.6592

This notification relates to disclosures made in accordance with 3.1.4(R)(1)(a) of the Disclosure and Transparency Rules.

Tony Guthrie Deputy Company Secretary

For further information please contact:

Investor Relations

Eric Rojas erojas@shire.com +1 781 482 0999

Sarah Elton-Farr seltonfarr@shire.com +44 1256 894157

Notes to editors

Shire enables people with life-altering conditions to lead better lives.

Through our deep understanding of patients' needs, we develop and provide healthcare in the areas of:

* Behavioral Health and Gastro Intestinal conditions

      * Rare Diseases
      * Regenerative Medicine
    as well as other symptomatic conditions treated by specialist physicians.

We aspire to imagine and lead the future of healthcare, creating value for
patients, physicians, policymakers, payors and our shareholders.
                                                                              

Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX

Press Release                                     

www.shire.com

-0- Dec/20/2012 15:45 GMT