SHIRE PLC: Director/PDMR Shareholding

PDMR Share Dealing 
December 20, 2012 - Shire plc (LSE: SHP, NASDAQ: SHPG) announces that on
December 19, 2012, Ann Judge exercised a Stock Appreciation Right Award granted
under the Shire Portfolio Share Plan and sold the resulting American Depository
Shares ("ADSs"). One ADS is equal to three Shire plc ordinary shares of 5p
Number of      Exercise   Number of ADSs  Sale price  
               price      received and              
ADSs exercised                    sold                   
15,000         $58.67         5,635       $93.6592   
This notification relates to disclosures made in accordance with 3.1.4(R)(1)(a)
of the Disclosure and Transparency Rules. 
Tony Guthrie
Deputy Company Secretary 
For further information please contact: 
Investor Relations                                                              
Eric Rojas                         +1 781 482 0999    
Sarah Elton-Farr               +44 1256 894157    
Notes to editors 
Shire enables people with life-altering conditions to lead better lives. 
Through our deep understanding of patients' needs, we develop and provide
healthcare in the areas of: 
* Behavioral Health and Gastro Intestinal conditions 

      * Rare Diseases
      * Regenerative Medicine
    as well as other symptomatic conditions treated by specialist physicians.

We aspire to imagine and lead the future of healthcare, creating value for
patients, physicians, policymakers, payors and our shareholders.

Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX

Press Release                                     

-0- Dec/20/2012 15:45 GMT
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