New Preliminary Efficacy Data for Daratumumab Presented at ASH

New Preliminary Efficacy Data for Daratumumab Presented at ASH

Company Announcement

  *Preliminary safety and efficacy data from final patients in part 1 of
    study continue to be encouraging
  *Data presented in oral presentation today at the ASH Annual Meeting
  *Part 2 of study, evaluating 24 month daratumumab dosing initiated

COPENHAGEN, Denmark, Dec. 9, 2012 (GLOBE NEWSWIRE) -- Genmab A/S
(Copenhagen:GEN) announced today new preliminary safety and efficacy data from
the Phase I/II clinical study of daratumumab (HuMax®-CD38) in multiple
myeloma.Of the three patients treated at the highest (and final) dose level
in the study (24 mg/kg of daratumumab), two achieved a partial response (PR)
and one achieved a minimal response (MR). Altogether, 8 of 12 patients in the
study who received daratumumab at a dose level of 4 mg/kg or higher achieved
at least a MR.

The data presented today at the American Society of Hematology (ASH) annual
meeting was from 32 patients who received daratumumab in doses up to 24 mg/kg.
The data continued to show no major safety issues with daratumumab. The most
relevant drug related adverse events were brief, low-grade infusion related
reactions and a temporary drop in the level of NK cells.

Part 2 of the study in which patients will receive multiple 8 mg/kg doses of
daratumumab for 24 months or until disease progression has been initiated.

"Data from this ongoing study of daratumumab in heavily pretreated multiple
myeloma patients continues to be very encouraging and we are excited that the
second part of the study where we will collect data on extended dosing of
daratumumab has begun," said Jan van de Winkel, Ph.D., Chief Executive Officer
of Genmab.

Prof. Torben Plesner, Vejle Hospital, Denmark, will present the slides from
today's oral presentation as part of Genmab's Post ASH Seminar, which will be
webcast on December 17 at

About the study

This ongoing Phase I/II dose escalation study will include a maximum of 108
patients with multiple myeloma that is relapsed or refractory to at least two
different prior treatments. The primary objective of the study is to establish
the safety profile of daratumumab and secondary objectives are to establish
maximum tolerated dose and efficacy. An independent data monitoring committee
evaluates the safety data for each cohort before dose-escalation.

About daratumumab

Daratumumab is a human CD38 monoclonal antibody with broad-spectrum killing
activity. Daratumumab is in clinical development for multiple myeloma (MM).
Daratumumab targets the CD38 molecule which is highly expressed on the surface
of multiple myeloma cells. Daratumumab could also have potential in other
cancers on which CD38 is expressed, including diffuse large B-cell lymphoma,
chronic lymphocytic leukemia, acute lymphoblastic leukemia, plasma cell
leukemia, acute myeloid leukemia, follicular lymphoma and mantle cell
lymphoma. In August 2012, Genmab granted Janssen Biotech, Inc. an exclusive
worldwide license to develop and commercialize daratumumab.

About Genmab A/S

Genmab is a publicly traded, international biotechnology company specializing
in the creation and development of differentiated human antibody therapeutics
for the treatment of cancer. Founded in 1999, the company's first marketed
antibody, ofatumumab (Arzerra^®), was approved to treat chronic lymphocytic
leukemia in patients who are refractory to fludarabine and alemtuzumab after
less than eight years in development. Genmab's validated and next generation
antibody technologies are expected to provide a steady stream of future
product candidates.Partnering of innovative product candidates and
technologies is a key focus of Genmab's strategy and the company has alliances
with top tier pharmaceutical and biotechnology companies. For more information


Rachel Curtis Gravesen, Senior Vice President, Investor Relations &
T: +45 33 44 77 20; M: +45 25 12 62 60; E:

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Company Announcement no. 36
CVR no. 2102 3884

Genmab A/S
Bredgade 34E
1260 Copenhagen K
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