SHIRE PLC: Director/PDMR Shareholding

December 17, 2012 - Shire plc (LSE: SHP, NASDAQ: SHPG) announces that Ms
Tatjana May exercised today an option over 1,108 Shire plc ordinary shares of
5p each ("Shares"), granted under the Shire Sharesave Scheme, at an exercise
price of £8.19 per Share. Ms May retained the resulting Shares. 
This notification is to satisfy the Company's obligations under 3.1.4(R)(1)(a)
of the Disclosure and Transparency Rules. 
Tony Guthrie 
Deputy Company Secretary 
For further information please contact: 
Investor Relations                                                              
Eric Rojas                         +1 781 482 0999    
Sarah Elton-Farr               +44 1256 894157    
Notes to editors 
Shire enables people with life-altering conditions to lead better lives. 
Through our deep understanding of patients' needs, we develop and provide
healthcare in the areas of: 
* Behavioral Health and Gastro Intestinal conditions 

      * Rare Diseases
      * Regenerative Medicine
    as well as other symptomatic conditions treated by specialist physicians.

We aspire to imagine and lead the future of healthcare, creating value for
patients, physicians, policymakers, payors and our shareholders.

Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX

Press Release                                     

-0- Dec/17/2012 15:00 GMT
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