SHIRE PLC: PDMR Share Dealing

PDMR Share Dealing

December 5, 2012 - Shire plc (LSE: SHP, NASDAQ: SHPG) announces that it was notified today that on December 4, 2012, Tatjana May exercised options over 80,000 Shire plc ordinary shares of 5p each ("Shares"). These options were granted under the 2000 Executive Share Option Scheme. Ms May chose to use a net settled cashless exercise facility run by the Company.

Number of Exercise Number of Number of Average sale

price Shares Shares price

Shares

received sold1

20,000 £12.57 6,110 3,614 £18.28351

60,000 £5.585 41,486 24,536 £18.28351

1 Shares sold to satisfy Ms May's personal tax liabilities.

This notification relates to disclosures made in accordance with 3.1.4(R)(1)(a) of the Disclosure and Transparency Rules.

Tony Guthrie Deputy Company Secretary

For further information please contact:

Investor Relations

Eric Rojas erojas@shire.com +1 781 482 0999

Sarah Elton-Farr seltonfarr@shire.com +44 1256 894157

Notes to editors

Shire enables people with life-altering conditions to lead better lives.

Through our deep understanding of patients' needs, we develop and provide healthcare in the areas of:

* Behavioral Health and Gastro Intestinal conditions

      * Rare Diseases
      * Regenerative Medicine
    as well as other symptomatic conditions treated by specialist physicians.

We aspire to imagine and lead the future of healthcare, creating value for
patients, physicians, policymakers, payors and our shareholders.

Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX

Press Release

www.shire.com

END

-0- Dec/05/2012 14:00 GMT