SHIRE PLC: PDMR Share Dealing

PDMR Share Dealing 
December 5, 2012 - Shire plc (LSE: SHP, NASDAQ: SHPG) announces that it was
notified today that on December 4, 2012, Tatjana May exercised options over
80,000 Shire plc ordinary shares of 5p each ("Shares"). These options were
granted under the 2000 Executive Share Option Scheme. Ms May chose to use a net
settled cashless exercise facility run by the Company. 
Number of    Exercise     Number of     Number of    Average sale   
             price       Shares        Shares          price      
                        received        sold1                     
20,000       £12.57        6,110         3,614        £18.28351    
60,000       £5.585       41,486        24,536        £18.28351    
1 Shares sold to satisfy Ms May's personal tax liabilities. 
This notification relates to disclosures made in accordance with 3.1.4(R)(1)(a)
of the Disclosure and Transparency Rules. 
Tony Guthrie
Deputy Company Secretary 
For further information please contact: 
Investor Relations                                                              
Eric Rojas                         +1 781 482 0999    
Sarah Elton-Farr               +44 1256 894157    
Notes to editors 
Shire enables people with life-altering conditions to lead better lives. 
Through our deep understanding of patients' needs, we develop and provide
healthcare in the areas of: 
* Behavioral Health and Gastro Intestinal conditions 

      * Rare Diseases
      * Regenerative Medicine
    as well as other symptomatic conditions treated by specialist physicians.

We aspire to imagine and lead the future of healthcare, creating value for
patients, physicians, policymakers, payors and our shareholders.

Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX 
Press Release                                      
-0- Dec/05/2012 14:00 GMT
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