PNAS Publishes Preclinical Results of EntreMed's 2ME2 for Multiple Sclerosis
ROCKVILLE, Md., Dec. 4, 2012
ROCKVILLE, Md., Dec. 4, 2012 /PRNewswire/ -- EntreMed, Inc. (Nasdaq: ENMD), a
clinical-stage pharmaceutical company developing therapeutics for the
treatment of cancer, announced today that preclinical results for its compound
2-methoxyestradiol (2ME2) were published on line in this week's Early Edition
of Proceedings of the National Academy of Sciences (PNAS). The study was
conducted at The Campbell Family Institute for Breast Cancer Research at
Princess Margaret Hospital and was led by Tak W. Mak, Ph.D.
(Logo: http://photos.prnewswire.com/prnh/20010620/ENMDLOGO )
Tak W. Mak, Ph.D., Director, The Campbell Family Cancer Research Institute,
commented on the study, "Multiple sclerosis (MS) is among the most common
autoimmune disorders in the northern hemisphere. There exists significant
unmet medical need for safe and effective drugs to treat MS. In this study,
we demonstrated that 2ME2, an endogenous metabolite of estradiol,
significantly inhibits lymphocyte activation and proliferation and
dramatically suppresses development of experimental MS. Our analysis of
cellular signaling pathways further reveals that 2ME2 exerts a potent
inhibition of Nuclear Factor of Activated T cells (NFAT). By extension, the
study provides for the first time a molecular rational for the use of 2ME2 as
a tolerable oral immunomodulatory agent for autoimmune disorders such as MS.
Other studies have shown that in humans, plasma levels of 2ME2 may increase
dramatically during the last months of pregnancy, which intriguingly appears
to correlate temporally with the remission of clinical symptoms reported in
some pregnant MS and rheumatoid arthritis (RA) patients. We believe that 2ME2
may offer a safe and effective treatment for such autoimmune disorders."
Ken Ren, Ph.D., EntreMed's Chief Executive Officer further commented, "In
addition to ENMD-2076 for oncology, 2ME2 represents another important asset
for our company with its strong IP position and sound safety profile.
Together with our previous findings of its disease modifying activity in RA
animal models, this study further extends 2ME2's therapeutic value to the
management of MS, RA and possibly other autoimmune disorders."
Dr. Ren continued, "We appreciate the international recognition by our peers.
For the next step, we intend to further advance 2ME2 development as part of
our global drug development plan and strategy to leverage resources both in
the US and China. We are currently exploring multiple strategies for the
development of 2ME2 including possible partnership opportunities. We believe
that the development of 2ME2 for autoimmune diseases fits well with our plan
to build a robust product pipeline and to add value for our long term
The article is entitled "2-Methoxyestradiol inhibits experimental autoimmune
encephalomyelitis through suppression of immune cell activation" and was
authored by Gordon S. Duncan, Dirk Brenner, Michael W. Tusche, Anne Brustle,
Christiane B. Knobbe, Andrew J. Elia, Thomas Mock, Mark R. Bray, Peter H.
Krammer and Tak W. Mak. The article is available at
EntreMed, Inc. is a clinical-stage pharmaceutical company employing a drug
development strategy primarily in the United States and China to develop
targeted therapeutics for the global market. Its lead compound, ENMD-2076, a
selective Aurora A and angiogenic kinase inhibitor for cancer, has completed
several Phase 1 studies in solid tumors, multiple myeloma, and leukemia, and
is currently completing a multi-center Phase 2 study in ovarian cancer.
EntreMed, Inc. recently initiated a dual-institutional Phase 2 study of
ENMD-2076 in triple-negative breast cancer. Its second compound, 2ME2, has
been investigated in clinical trials in oncology patients, and is the subject
of a successful IND filing for clinical use to treat RA. Additional
information about EntreMed is available on the Company's web site at
www.entremed.comand in various filings with the Securities and Exchange
Commission (the SEC).
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SOURCE EntreMed, Inc.
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