Precision BioSciences Announces Publication of Cotton Trait Stacking Success in Collaboration with Bayer CropScience

  Precision BioSciences Announces Publication of Cotton Trait Stacking Success
  in Collaboration with Bayer CropScience

Herbicide Tolerance Gene Precisely Inserted Adjacent to Insect Resistance Gene
                using Site-Specific Genome Editing Technology

Business Wire

RESEARCH TRIANGLE PARK, N.C. -- November 26, 2012

Precision BioSciences, Inc., a leader in the field of genome engineering,
today announced that research, The Bayer Scientific Magazine, has published an
article describing the successful use of Precision’s DNE technology to modify
the genome of cotton. The article describes pioneering work performed by
Kathleen D’Halluin and her colleagues at Bayer CropScience, who used an
engineered DNE meganuclease produced by Precision to insert a gene into
cotton. In doing so, D’Halluin was able to produce a “trait stack” in which
two genes conferring valuable traits were targeted to the same location in the
cotton genome. This is the first time that a gene editing approach, such as
DNE, has been used successfully in cotton. Precision’s patent-protected
technology provides plant researchers with exquisite control over a plant
genome and offers enormous improvements in breeding efficiency.

“We are enormously pleased with the results published by Bayer CropScience,”
said Jeff Smith, Precision BioSciences’ Chief Scientific Officer. “Cotton is a
notoriously difficult plant to manipulate and we expect DNE to play an
important role in the genetic modification of such recalcitrant crop species.”

“Precision’s long-standing focus on the development of the world's premier
genome editing technology is continuing to pay off,” said Precision
BioSciences CEO Matthew Kane. “We look forward to solving future unmet genome
engineering challenges requiring the levels of precision that only DNE
allows.”

A link to the full pdf containing this article can be found at:
http://www.research.bayer.com/en/straight-into-the-cotton-genome.aspx

About Precision BioSciences

Precision BioSciences’ mission is to continually provide, improve, and enable
the world’s most powerful genome engineering technology. Precision’s
proprietary Directed Nuclease Editor^TM (DNE) technology enables the
production of genome editing enzymes that can insert, remove, modify, and
regulate essentially any gene in mammalian or plant cells.

Precision BioSciences’ vision is to be the conduit through which the world’s
greatest genome engineering challenges are solved. Precision has successfully
utilized its DNE technology to create innovative products in partnerships with
many of the world’s largest biopharmaceutical, agbiotech, and animal research
firms. Internally, Precision is developing applications of DNE in biological
production and human therapeutics. For additional information, please visit
www.precisionbiosciences.com.

Contact:

Precision BioSciences, Inc.
Chelsea Lynam, +1 919-314-5512
chelsea.lynam@precisionbiosciences.com