SHIRE PLC: Block Listing Six Monthly Return

Block Listing Six Monthly Return 
November 23, 2012 - Shire plc (LSE: SHP, NASDAQ: SHPG) 
Name of applicant:                     Shire plc                                
                                                                           
Name of scheme:                        2000 Executive Share Option Scheme       
                                                                           
Period of return:            From:     May 23, 2012     To:   November 22, 2012 
                                                                           
Balance of unallotted securities under 3,483,681                               
scheme(s) from previous return:                                                 
                                                                           
Plus: The amount by which the block    Nil                                     
scheme(s) has been increased since the                                         
date of the last return (if any                                                
increase has been applied for):                                                 
                                                                           
Less: Number of securities issued/     7,230                                   
allotted under scheme(s) during period                                         
(see LR3.5.7G):                                                                 
                                                                           
Equals: Balance under scheme(s) not    3,476,451                               
yet issued/allotted at end of period:                                           
Name of applicant:                     Shire plc                                
                                                                           
Name of scheme:                        Shire Sharesave Scheme                   
                                                                           
Period of return:            From:     May 23, 2012     To:   November 22, 2012 
                                                                           
Balance of unallotted securities under 5,392                                   
scheme(s) from previous return:                                                 
                                                                           
Plus: The amount by which the block    110,000                                 
scheme(s) has been increased since the                                         
date of the last return (if any                                                
increase has been applied for):                                                 
                                                                           
Less: Number of securities issued/     Nil                                     
allotted under scheme(s) during period                                         
(see LR3.5.7G):                                                                 
                                                                           
Equals: Balance under scheme(s) not    115,392                                 
yet issued/allotted at end of period:                                           
Name of applicant:                     Shire plc                                
                                                                           
Name of scheme:                        Portfolio Share Plan                     
                                                                           
Period of return:            From:     June 8, 2012     To:   November 22, 2012 
                                                                           
Balance of unallotted securities under Nil                                     
scheme(s) from previous return:                                                 
                                                                           
Plus: The amount by which the block    2,665,000                               
scheme(s) has been increased since the                                         
date of the last return (if any                                                
increase has been applied for):                                                 
                                                                           
Less: Number of securities issued/     903                                     
allotted under scheme(s) during period                                         
(see LR3.5.7G):                                                                 
                                                                           
Equals: Balance under scheme(s) not    2,664,097                               
yet issued/allotted at end of period:                                           
Name of contact:                        Tony Guthrie, Deputy Company Secretary  
                                                                           
Address of contact:                     Hampshire International Business Park   


                                                                               
                                        Basingstoke, Hampshire, RG24 8EP       


                                                                           
Telephone number of contact:            01256 894746                            
For further information please contact: 
Investor Relations                                                              
                                                                           
Eric Rojas                              erojas@shire.com     +1 781 482 0999    
                                                                           
Sarah Elton-Farr                        seltonfarr@shire.com +44 1256 894157    
Notes to editors 
Shire enables people with life-altering conditions to lead better lives. 
Through our deep understanding of patients' needs, we develop and provide
healthcare in the areas of: 
* Behavioral Health and Gastro Intestinal conditions 


      * Rare Diseases
      * Regenerative Medicine
    as well as other symptomatic conditions treated by specialist physicians.

We aspire to imagine and lead the future of healthcare, creating value for
patients, physicians, policymakers, payors and our shareholders.


                                                                       
Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX 
Press Release                                      
                                              
www.shire.com                                      
END 
-0- Nov/23/2012 14:45 GMT
 
 
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