SHIRE PLC: Transaction in Own Shares

Transaction in Own Shares 
November 21, 2012 - Shire plc (the "Company") (LSE: SHP, NASDAQ: SHPG),
announces that in accordance with the authority granted by shareholders at the
Company's Annual General Meeting on April 24, 2012 it purchased 130,000 of its
ordinary shares of 5 pence each on November 21, 2012. The highest and lowest
price paid was 1787.00 pence per share and 1761.00 pence per share
The purchased shares will be held as treasury shares. Following the above
purchase, the Company holds 1,709,134 shares as treasury shares and has
560,832,079 shares in issue (excluding treasury shares). 
For further information please contact: 
Investor Relations                                                              
Eric Rojas                         +1 781 482 0999    
Sarah Elton-Farr               +44 1256 894157    
Notes to editors 
Shire enables people with life-altering conditions to lead better lives. 
Through our deep understanding of patients' needs, we develop and provide
healthcare in the areas of: 
* Behavioral Health and Gastro Intestinal conditions 

      * Rare Diseases
      * Regenerative Medicine
    as well as other symptomatic conditions treated by specialist physicians.

We aspire to imagine and lead the future of healthcare, creating value for
patients, physicians, policymakers, payors and our shareholders.

Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX 
Press Release                                      
-0- Nov/21/2012 17:45 GMT
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